Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review

Steglich, Patrick; Lecci, Giulia; Mai, Christian

doi:10.3390/s22082901

Cited by 34 publications

(12 citation statements)

References 130 publications

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“…PICs attract a lot of research interest and are shown to be promising candidates in a range of applications including sensing [40,41], especially in biomedical contexts [42,43] and photonic computing [44] but to date, research has been primarily driven the introduction and scaling of PICs for optical communications [45]. PICs offer strong advantages over electronic integrated circuits, namely higher available speed, large integration capacity, and compatibility with existing processing flows [46].PICs provide opportunities for miniaturisation of bulky optical systems, providing better access to bio-sensing spectroscopy applications to enable point-of-care diagnostics [47] and size and weight appropriate beam steering for light based sensing systems for utilisation in cars and drones [48].…”

Section: Photonic Integrated Circuits (Pics)mentioning

confidence: 99%

Active region doping strategies in O-band InAs/GaAs quantum-dot lasers

Jarvis

Maglio

Shutts

et al. 2022

Novel in-Plane Semiconductor Lasers XXI

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Three techniques for improving gain in InAs quantum dot lasers are examined.Silicon photonics is a promising solution for meeting increasing global data bandwidth demands. However, silicon itself is a poor emitter due to its indirect bandgap. One potential candidate for light sources for on-chip devices is the monolithic growth of III-V quantum dot materials onto silicon, however, III-V quantum dot materials exhibit reduced gain due to the differences in the population of electron and hole states and ultimately because of the difference in electron and hole effective masses. P-type modulation doping is a well-established strategy for improving gain in InAs quantum dot lasers on both native GaAs and silicon substrates. The doping density and positioning is optimised for a given wafer design, and ground state lasing at room temperature for a 400µm lasing cavity is demonstrated, in addition to reduced sensitivity of threshold current to temperature.Optimized p-type modulation doping is compared to a relatively new approach to enhancing gain -direct n-type doping of the quantum dots. It is found to improve the gain in low loss operation, unlike p-type modulation doping. However, direct n-type doping detrimentally showed increased threshold current dependence compared with p-type modulation doping and decreased the maximum temperature at which ground state lasing could be attained.A novel third method is investigated in which both p-type modulation doping and direct n-type doping are applied to a device simultaneously, referred to as co-doping. Co-doping reduced the threshold current density from 245Acm −2 to 132Acm −2 at 27 • C and 731Acm −2 to 312Acm −2 at 97 • C, compared to undoped devices. The reduction was greater than for either individual doping strategy alone. Co-doping also retained the beneficial reduction in the sensitivity of the threshold current density to temperature provided by the p-type modulation doping.

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Section: Photonic Integrated Circuits (Pics)mentioning

confidence: 99%

Active region doping strategies in O-band InAs/GaAs quantum-dot lasers

Jarvis

Maglio

Shutts

et al. 2022

Novel in-Plane Semiconductor Lasers XXI

View full text Add to dashboard Cite

show abstract

“…[ 1–5 ] However, current detection methods, such as surface‐enhanced Raman scattering (SERS), surface plasmon resonance (SPR), and photoacoustic (PA) imaging‐based detection, suffer from problems such as long signal collection time and require specialized equipment. [ 6–8 ] Hence, a self‐reporting platform that resolves the challenges faced by current detection techniques while enabling easy‐to‐use cancer diagnostics is a necessity.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] However, current detection methods, such as surface-enhanced Raman scattering (SERS), surface plasmon resonance (SPR), and photoacoustic (PA) imaging-based detection, suffer from problems such as long signal collection time and require specialized equipment. [6][7][8] Hence, a self-reporting platform that resolves the challenges faced by current detection techniques while enabling easy-to-use cancer diagnostics is a necessity. Nanostructured carbon-based sensors fabricated from materials such as graphene, carbon nanotubes (CNT), and quantum dots (QD) can achieve targeted recognition and transduction properties by controlling their macro-and micro-structure using stimuli-responsive parameters.…”

Section: Introductionmentioning

confidence: 99%

A Self‐Reporting Mineralized Conductive Hydrogel Sensor with Cancer‐Selective Viscosity, Adhesiveness, and Stretchability

Roy

Lee

Ryplida

et al. 2023

Adv Funct Materials

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A cancer‐selective self‐reporting sensor based on a redox‐responsive mineralized conductive hydrogel (M‐Hydrogel) is proposed with cancer‐specific viscosity, adhesive strength, stretchability, tunable conductivity, and fluorescence. The redox‐triggered release of carbonized polydopamine (cPDA) from the loaded disulfide‐crosslinked polymer dots (PD@cPDA) in the hydrogel matrix modulates the macroporous structure responsible for self‐recognizable cancer sensing and photothermal activity for cancer therapy. The self‐reporting nature of the M‐Hydrogel sensor is highlighted when in vicinity of a high glutathione (GSH) level owing to the controllable pore size and H‐bonding by cPDA, as confirmed by experiments on cancer cells (HeLa, PC3, B16‐F10‐GFP, and SNU‐C2A) and normal cells (CHO‐K1). The lower viscosity during syringe test along with the exceptional adhesiveness and stretchability with various cancer cells, combined with a high wireless pressure‐sensing response absent in normal conditions, confirms the dependence of self‐recognizable behavior on the cancer microenvironment. The M‐Hydrogel demonstrates excellent ex situ sensing with tumor ablation, after implantation in mice xenografted with HeLa cells, with the wireless sensing system, enabling real‐time analysis coupled with the upregulation of pro‐apoptotic markers P53 and BAX in the tumor. Therefore, this self‐reporting sensor may facilitate a strategy for innovative and convenient cancer diagnostics.

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“…The optical signal is produced by specific biological interactions with the analyte, as in other detection technologies, but with the advantage of not requiring a direct electrical connection. Different optical properties, such as absorption, fluorescence, internal reflection, and surface plasmon resonance, can be explored to monitor biorecognition in biosensors [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Optical Biosensor for the Detection of Infectious Diseases Using the Copolymer F8T2 with Application to COVID-19

Bassi

Bom

Budel

et al. 2022

Sensors

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The coronavirus pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has accelerated the development of biosensors based on new materials and techniques. Here, we present our effort to develop a fast and affordable optical biosensor using photoluminescence spectroscopy for anti-SARS-CoV-2 antibody detection. The biosensor was fabricated with a thin layer of the semiconductor polymer Poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-2,2′-bithiophene-5,5′-diyl)] (F8T2) as a signal transducer material. We mounted the biosensors by depositing a layer of F8T2 and an engineered version of RBD from the SARS-CoV-2 spike protein with a tag to promote hydrophobic interaction between the protein and the polymeric surface. We validated the biosensor sensitivity with decreasing anti-RBD polyclonal IgG concentrations and challenged the biosensor specificity with human serum samples from both COVID-19 negative and positive individuals. The antibody binding to the immobilized antigen shifted the F8T2 photoluminescence spectrum even at the low concentration of 0.0125 µg/mL. A volume as small as one drop of serum (100 µL) was sufficient to distinguish a positive from a negative sample without requiring multiple washing steps and secondary antibody reactions.

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Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review

Cited by 34 publications

References 130 publications

Active region doping strategies in O-band InAs/GaAs quantum-dot lasers

Active region doping strategies in O-band InAs/GaAs quantum-dot lasers

A Self‐Reporting Mineralized Conductive Hydrogel Sensor with Cancer‐Selective Viscosity, Adhesiveness, and Stretchability

Optical Biosensor for the Detection of Infectious Diseases Using the Copolymer F8T2 with Application to COVID-19

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