Surface Plasmon Resonance: A Boon for Viral Diagnostics

Singh, Pranveer

doi:10.1016/b978-0-12-809633-8.12245-9

Cited by 27 publications

(19 citation statements)

References 131 publications

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“…• Based on the dimension: The nanobiosensor products can be classified into three categories based on the dimensions which are pushed to the nanometer scale: a. [63], [64] Optical absorption-based nanobiosensors [65] Fluorescent nanobiosensors [66], [67] Light scattering nanobiosensors [68], [69] Surface plasmon resonance (SPR) based nanobiosensors [70], [71] Surface-enhanced Raman scattering (SERS) nanobiosensors [72], [73] Inductively coupled plasma mass spectroscopy (ICP-MS) nanobiosensors [74], [75] • Ultrahigh sensitivity: Use of nanotechnology has made biosensors more adept in terms of detection capability and sensitivity.…”

Section: ) Classifications Of Nanobiosensorsmentioning

confidence: 99%

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Pramanik

Solanki

Debnath³

et al. 2020

IEEE Access

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Healthcare sector is probably the most benefited from the applications of nanotechnology. The nanotechnology, in the forms of nanomedicine, nanoimplants, nanobiosensors along with the internet of nano things (IoNT), has the potential to bring a revolutionizing advancement in the field of medicine and healthcare services. The primary aim of this paper is to explore the clinical and medical possibilities of these different implementations of nanotechnology. This paper provides a comprehensive overview of nanotechnology, biosensors, nanobiosensors, and IoNT. Furthermore, multilevel taxonomies of nanotechnology, nanoparticles, biosensors, nanobiosensors, and nanozymes are presented. The potential medical and clinical applications of these technologies are discussed in details with several examples. This paper specifically focuses on IoNT and its role in healthcare. In addition to describing a general architecture of IoNT for healthcare, the communication architecture of the IoNT is also explained. The challenges in the successful realization of IoNT are also discussed critically, along with a special discussion on internet of bio-nano things (IoBNT) and its potential in making IoNT more compatible to human body.

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Section: ) Classifications Of Nanobiosensorsmentioning

confidence: 99%

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Pramanik

Solanki

Debnath³

et al. 2020

IEEE Access

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“…Surface plasmon resonance is another diagnostic platform that has been extensively used for the detection of viruses and bacteria [ 75 , 76 ]. Surface plasmons are oscillating electrons on the metallic surfaces that can be excited by shining specific wavelengths of light under certain configurations.…”

Section: Surface-plasmon-resonance-based Platformsmentioning

confidence: 99%

Detection of Bacterial and Viral Pathogens Using Photonic Point-of-Care Devices

et al. 2020

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Infectious diseases caused by bacteria and viruses are highly contagious and can easily be transmitted via air, water, body fluids, etc. Throughout human civilization, there have been several pandemic outbreaks, such as the Plague, Spanish Flu, Swine-Flu, and, recently, COVID-19, amongst many others. Early diagnosis not only increases the chance of quick recovery but also helps prevent the spread of infections. Conventional diagnostic techniques can provide reliable results but have several drawbacks, including costly devices, lengthy wait time, and requirement of trained professionals to operate the devices, making them inaccessible in low-resource settings. Thus, a significant effort has been directed towards point-of-care (POC) devices that enable rapid diagnosis of bacterial and viral infections. A majority of the POC devices are based on plasmonics and/or microfluidics-based platforms integrated with mobile readers and imaging systems. These techniques have been shown to provide rapid, sensitive detection of pathogens. The advantages of POC devices include low-cost, rapid results, and portability, which enables on-site testing anywhere across the globe. Here we aim to review the recent advances in novel POC technologies in detecting bacteria and viruses that led to a breakthrough in the modern healthcare industry.

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“…From this perspective, plasmonic-based biosensors can be a promising alternative to the immunoenzymatic tests currently available by providing cost-effective diagnostic methods and real-time monitoring [ 12 ]. Among the biosensor technologies that have emerged in the last decades for virus research, plasmonic resonance applications have triggered significant interest, in view of their versatility, label-free monitoring, and low response time [ 13 , 14 , 15 ]. Thus, surface plasmon resonance (SPR) biosensors represent a promising approach to reach ultra-low detection limits of antibodies from clinical specimens [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Antibodies against Hepatitis A Virus (HAV) by a Surface Plasmon Resonance (SPR) Biosensor: A New Diagnosis Tool Based on the Major HAV Capsid Protein VP1 (SPR-HAVP1)

Santos

Alves

Pinto

et al. 2021

Sensors

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Hepatitis A (HA) is an acute human infectious disease caused by a positive single-stranded RNA virus (HAV). It is mainly acquired through the fecal–oral route and is primarily spread by contact between people and exposure to contaminated water and food. Recently, large outbreaks of HA have been reported by low and moderate endemicity countries, emphasizing its importance in public health and the need for rapid and large-scale diagnostic tests to support public health decisions on HA. This work proposes a new tool for HAV diagnosis based on the association of surface plasmonic resonance with major capsid protein VP1 (SPR-HAVP1 assay), detecting IgM antibodies for HAV in human serum samples. Structural analyses of VP1 B-lymphocyte epitopes showed continuous and discontinuous epitopes. The discontinuous epitopes were identified in the N-terminal region of the VP1 protein. Both epitope types in the VP1 protein were shown by the reactivity of VP1 in native and denaturing conditions to IgM anti-HAV, which was favorable to tests of VP1 in the SPR assays. SPR-HAVP1 assays showed good performance in the detection of IgM polyclonal antibody anti-HAV. These assays were performed using a COOH5 sensor chip functionalized with VP1 protein. The sensorgram record showed a significant difference between positive and negative serum samples, which was confirmed by analysis of variation of initial and final dissociation values through time (ΔRUd/t). The data gathered here are unequivocal evidence that the SPR-HAVP1 strategy can be applied to detect IgM antibodies in human serum positive to the HAV. This is a new tool to be explored to diagnose human HAV infections.

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Surface Plasmon Resonance: A Boon for Viral Diagnostics

Cited by 27 publications

References 131 publications

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Detection of Bacterial and Viral Pathogens Using Photonic Point-of-Care Devices

Detection of Antibodies against Hepatitis A Virus (HAV) by a Surface Plasmon Resonance (SPR) Biosensor: A New Diagnosis Tool Based on the Major HAV Capsid Protein VP1 (SPR-HAVP1)

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