Summary:A computer simulation model is proposed to study film growth and surface roughness in aqueous (A) solution of hydrophobic (H) and hydrophilic (P) groups on a simple three dimensional lattice of size L x × L y × L z with an adsorbing substrate. Each group is represented by a particle with appropriate characteristics occupying a unit cube (i.e., eight sites). The Metropolis algorithm is used to move each particle stochastically. The aqueous constituents are allowed to evaporate while the concentration of H and P is constant. Reactions proceed from the substrate and bonded particles can hop within a fluctuating bond length. The film thickness (h) and its interface width (W) are examined for hardcore and interacting particles for a range of temperature (T ). Simulation data show a rapid increase in h and W followed by its non-monotonic growth and decay before reaching steady-state and near equilibrium (h s , W s ) in asymptotic time step limit. The growth can be described by power laws, e.g., h ∝ t γ , W ∝ t β with a typical value of γ ≈ 2, β ≈ 1 in initial time regime followed by γ ≈ 1.5, β ≈ 0.8 at T = 0.5. For hardcore system, the equilibrium film thickness (h s ) and surface roughness (w s ) seem to scale linearly with the temperature, i.e., h s = 6.206 + 0.302T, W s = 1 255 + 0.425T at low T and h s = 6.54 + 0.198T, W s = 1.808 + 0.202T at higher T . For interacting functional groups in contrast, the long time (unsaturated) film thickness and surface roughness, h s and W s decay rapidly followed by a slow increase on raising the temperature.Growth of the average film thickness at a temperature T = 5.