Surface nano-functionalization of biomaterials

Liu, Xuanyong; Chu, Paul K.; Ding, Changfeng

doi:10.1016/j.mser.2010.06.013

Cited by 258 publications

(126 citation statements)

References 178 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…The over use of antibiotics and increased antibiotic resistance from pathogens is considered one of the most concerning health threats of the 21st century, and new technologies addressing the issue are desperately needed [9][10][11][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

“…For combinatorial thin films with inorganic composition-gradients, however, most research and development has been focused on materials for electronic, optical, magnetic and energy-related applications [7,8], and corresponding investigations for biomaterials applications are scarce. Although thin film coatings for biomedical implants and devices are all the while being widely researched to improve functionality and safety, no simple solution exists to, for instance, combat or prevent implant-associated infection [9][10][11]. This work presents a combinatorial approach to synthesizing an inorganic composition-gradient between silver and titanium, using a custom built physical vapor deposition (PVD) system, and aims to correlate the resulting composition and structure with antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

et al. 2015

View full text Add to dashboard Cite

Growing demand for orthopedic and dental implants has spurred researchers to develop multifunctional coatings, combining tissue integration with antibacterial features. A possible strategy to endow titanium (Ti) with antibacterial properties is by incorporating silver (Ag), but designing a structure with adequate Ag + release while maintaining biocompatibility has been shown difficult. To further explore the composition-structure-property relationships between Ag and Ti, and its effects against bacteria, this study utilized a combinatorial approach to manufacture and test a single sample containing a binary Ag-Ti oxide gradient. The sample, sputter deposited in a reactive (O 2 ) environment using a custom built combinatorial physical vapor deposition (PVD) system, was shown to be effective against Staphylococcus aureus with viability reductions ranging from 17 to above 99 %, depending on amount of Ag + released from its different parts. The Ag content along the gradient ranged from 35 to 62 wt%, but it was found that structural properties such as varied porosity and degree of crystallinity, rather than amount of incorporated Ag governed the Ag + release and resulting antibacterial activity. The coating also demonstrated in vitro apatite forming abilities, where structural variety along the sample was shown to alter the hydrophilic behavior, with degree of hydroxyapatite (HA) deposition varying accordingly. By means of combinatorial synthesis, a single gradient sample was able to display intricate compositional and structural features affecting its biological response, which would otherwise require a series of coatings. The current findings suggest that future implant coatings incorporating Ag as an antibacterial agent could be structurally enhanced to better suit clinical requirements.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

et al. 2015

View full text Add to dashboard Cite

show abstract

“…[15][16] Peptide-based approaches to the generation of nanostructured titania are therefore of current interest. However, a significant obstacle to developing versatile and reliable peptide-based strategies for the generation and organization/activation of nanostructured inorganic materials is our limited understanding of how to exploit the relationship between peptide sequence and corresponding materials-binding affinity.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Peptide–TiO₂ Interfaces: Isoenergetic Binding via Either Entropically or Enthalpically Driven Mechanisms

Sultan

Westcott

Hughes

et al. 2016

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

A major barrier to the systematic improvement of biomimetic peptide-mediated strategies for the controlled growth of inorganic nanomaterials in environmentally benign conditions lies in the lack of clear conceptual connections between the sequence of the peptide and its surface binding affinity, with binding being facilitated by non-covalent interactions. Peptide conformation, both in the adsorbed and non-adsorbed state, is the key relationship that connects peptide-materials binding with peptide sequence. Here, we combine experimental peptide-titania binding characterization with state-of-the-art conformational sampling via molecular simulations to elucidate these structure/binding relationships for two very different titania-binding peptide sequences. The two sequences (Ti-1: QPYLFATDSLIK and Ti-2:GHTHYHAVRTQT) differ in their overall hydropathy, yet via quartz-crystal microbalance measurements and predictions from molecular simulations, we show these sequences both support very similar, strong titania-binding affinities. Our molecular simulations reveal that the two sequences exhibit profoundly different modes of surface binding, with Ti-1 acting as an entropically-driven binder while Ti-2 behaves as an enthalpically-driven binder. The integrated approach presented here provides a rational basis for peptide sequence engineering to achieve the in-situ growth and organization of titania nanostructures in aqueous media and for the design of sequences suitable for a range of technological applications that involve the interface between titania and biomolecules.3

show abstract

“…This energy (plasma, laser or ions bombardment) involves high temperature that can reach, in some cases, up to 2000 °C [193,194]. Increased temperature during deposition facilitates a firm fixation of the coating onto the surface but it limits the selection for materials that can be coated.…”

Section: Dry Deposition Techniquesmentioning

confidence: 99%

Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

et al. 2012

View full text Add to dashboard Cite

Abstract:The mechanical and biological properties of bone implants need to be optimal to form a quick and firm connection with the surrounding environment in load bearing applications. Bone is a connective tissue composed of an organic collagenous matrix, a fine dispersion of reinforcing inorganic (calcium phosphate) nanocrystals, and bone-forming and -degrading cells. These different components have a synergistic and hierarchical structure that renders bone tissue properties unique in terms of hardness, flexibility and regenerative capacity. Metallic and polymeric materials offer mechanical strength and/or resilience that are required to simulate bone tissue in load-bearing applications in terms of maximum load, bending and fatigue strength. Nevertheless, the interaction between devices and the surrounding tissue at the implant interface is essential for success or failure of implants. In that respect, coatings can be applied to facilitate the process of bone healing and obtain a continuous transition from living tissue to the synthetic implant. Compounds that are inspired by inorganic (e.g., hydroxyapatite crystals) or organic (e.g., collagen, extracellular matrix components, enzymes) components of bone tissue, are the most obvious candidates for application as implant coating to improve the performance of bone implants. This review provides an overview of recent trends and strategies in surface engineering that are currently investigated to improve the biological performance of bone implants in terms of functionality and biological efficacy. OPEN ACCESSCoatings 2012, 2 96

show abstract

Surface nano-functionalization of biomaterials

Cited by 258 publications

References 178 publications

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

Aqueous Peptide–TiO₂ Interfaces: Isoenergetic Binding via Either Entropically or Enthalpically Driven Mechanisms

Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

Contact Info

Product

Resources

About

Surface nano-functionalization of biomaterials

Cited by 258 publications

References 178 publications

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

Aqueous Peptide–TiO2 Interfaces: Isoenergetic Binding via Either Entropically or Enthalpically Driven Mechanisms

Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

Contact Info

Product

Resources

About

Aqueous Peptide–TiO₂ Interfaces: Isoenergetic Binding via Either Entropically or Enthalpically Driven Mechanisms