Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

Bosco, Ruggero; Beucken, Jeroen van den; Leeuwenburgh, Sander C.G.; Jansen, John A.

doi:10.3390/coatings2030095

Cited by 214 publications

(132 citation statements)

References 196 publications

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“…), or to mix these polymers with bioactive materials (e.g., bioactive glass, hydroxyapatite, β-TCP, calcium silicate, etc.) [3][4][5][6]. The main problem of coatings is to guarantee a proper adhesion to the polymeric surface.…”

Section: Introductionmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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Polymers are materials widely used in biomedical science because of their biocompatibility, and good mechanical properties (which, in some cases, are similar to those of human tissues); however, these materials are, in general, chemically and biologically inert. Surface characteristics, such as topography (at the macro-, micro, and nano-scale), surface chemistry, surface energy, charge, or wettability are interrelated properties, and they cooperatively influence the biological performance of materials when used for biomedical applications. They regulate the biological response at the implant/tissue interface (e.g., influencing the cell adhesion, cell orientation, cell motility, etc.). Several surface processing techniques have been explored to modulate these properties for biomedical applications. Despite their potentials, these methods have limitations that prevent their applicability. In this regard, laser-based methods, in particular laser surface texturing (LST), can be an interesting alternative. Different works have showed the potentiality of this technique to control the surface properties of biomedical polymers and enhance their biological performance; however, more research is needed to obtain the desired biological response. This work provides a general overview of the basics and applications of LST for the surface modification of polymers currently used in the clinical practice (e.g., PEEK, UHMWPE, PP, etc.). The modification of roughness, wettability, and their impact on the biological response is addressed to offer new insights on the surface modification of biomedical polymers.

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Section: Introductionmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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“…25 Concerning biomaterials for bone tissue, synthetic hydroxyapatite (HA) has been widely used in bone repair 26 and for application as implant coating to improve the performance of bone implants. 27 Small levels of ionic substitution by silicon (Si) have significant effects on osteoclastic and osteoblastic responses both in vitro and in vivo. 28 The favourable effects of Si substitution in HA on bone cells have been related to passive and active mechanisms as material solubility increase, topographical changes, grain size reduction, surface charge modifications and ionic release of Si and Ca.…”

Section: Introductionmentioning

confidence: 99%

Effects of immobilized VEGF on endothelial progenitor cells cultured on silicon substituted and nanocrystalline hydroxyapatites

et al. 2016

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“…The demands on medical implants as safe and long-term solutions for problems with the musculoskeletal system are rapidly growing due to increased life expectancy, changing lifestyles and improved implant technology [1]. At present, problems related to orthopedic, oral and maxillofacial disorders annually affect millions of patients.…”

Section: Introductionmentioning

confidence: 99%

X-ray and neutron investigation of self-assembled lipid layers on a titanium surface

et al. 2013

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Titanium is the most widely preferred metal material for bone reconstruction in orthopedics and dentistry. To improve its biological performance, various coatings can be applied. In this investigation, a biomimetic coating on a model implant surface was studied in X-ray and neutron reflectivity experiments to probe the quality of this coating, which is only few nanometers thick. Titanium was deposited on polished silicon surfaces using a magnetron sputtering technique. To improve the lipid coating’s stability, a stronger van der Waals interaction was first created between the implant surface and the biomimetic coating by adding a phosphonic acid (n-octadecylphosphonic acid – OPA) monolayer onto the surfaces. Then, three monolayers of POPE (phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine) were transferred using the Langmuir-Blodgett (LB) and Langmuir-Schaefer (LS) techniques. The analysis of X-ray and neutron specular reflectivity data shows that OPA molecules cover the model implant surface completely and that approximately 50% coverage of POPE can be achieved by LB and LS transfer.

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Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

Cited by 214 publications

References 196 publications

Laser Surface Texturing of Polymers for Biomedical Applications

Laser Surface Texturing of Polymers for Biomedical Applications

Effects of immobilized VEGF on endothelial progenitor cells cultured on silicon substituted and nanocrystalline hydroxyapatites

X-ray and neutron investigation of self-assembled lipid layers on a titanium surface

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