Surface morphology control of polylactide microspheres enclosing irinotecan hydrochloride

Yoshizawa, Hidekazu; Nishino, Satoru; Shiomori, Koichiro; Natsugoe, Shoji; Aiko, Takashi; Kitamura, Yoshiro

doi:10.1016/j.ijpharm.2005.02.010

Cited by 23 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Injection of NP suspensions resulted in a prolonged presence of the drug in the blood, with appreciable levels of drug still present in the circulation 24 h after administration. When administered as a free drug, SN-38 is rapidly eliminated from the circulation (Williams et al, 2003;Yoshizawa et al, 2005). In addition, injection of TNPs resulted in higher SN-38 concentrations in comparison to injection of NNPs 24 h after administration (P < 0.05).…”

Section: Resultsmentioning

confidence: 98%

“…Camptothecin (CPT), a plant alkaloid extracted from Camptotheca acuminate Kunii et al, 2008), and its related analogues are a group of anticancer agents that show great therapeutic potential; their unique mechanism of action is based on targeting the nuclear enzyme topoisomerase I (Yoshizawa et al, 2005). An important chemical feature of camptothecins and related analogues is the rapid and reversible hydrolysis from a closed lactone ring to the carboxylate form.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38

Ebrahimnejad

Dinarvand

Jafari

et al. 2011

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38

Ebrahimnejad

Dinarvand

Jafari

et al. 2011

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…In contrast to these observations, micrographs representing MS encapsulated with PLGA by solvent evaporation/extraction method showed spheres with mean diameter of 65 mm covered with smooth layer due to a rather slow polymer precipitation in the amorphous state (Arshady 1991;Ruan and Feng 2003;Yoshizawa et al 2005) (Figure 10(a)). Besides, the formation of small, self-encapsulated PLGA-MS was frequent with augmenting polymer concentration in formula; as a direct result of the presence of excess amount of polymer.…”

Section: Ms Characterization and Surface Morphological Studymentioning

confidence: 82%

Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy

Madani¹,

Chaumeil²

2008

Journal of Microencapsulation

View full text Add to dashboard Cite

Indomethacin-loaded dietheylaminoethyl trisacryl Õ microspheres (DEAE-MS), originally designed for therapeutic embolization, were encapsulated using two methods: coacervation and solvent evaporation/extraction. This encapsulation was achieved using a biocompatible polymer, the PLGA 50 : 50, and aimed to control the release of the anti-inflammatory non-steroidal drug (AINSD) in the occluded vessel. PLGA degradation study showed that it had an erosion half-life of $35 days. Scanning electron microscopy (SEM) photographs showed that microcapsules (MC) prepared by coacervation had a wrinkled surface while those prepared using solvent-removal process showed non-porous, smooth surface, those of originally DEAE-MS showed a macroporous, rough surface. The mean diameters were 61 mm for naked DEAE-MS vs. 71 mm and 65 mm for MC prepared by coacervation and solvent evaporation/extraction method, respectively. In vitro release study of indomethacin adsorbed onto MS indicated that drug release from MC was controlled by a diffusion process. Indomethacin diffusivity from MC was much lower than its free diffusivity from MS (mean 14.5 and 10.5 times lower for formulations prepared by coacervation and solvent evaporation/extraction method, respectively). This indicates that efficient indomethacin concentrations could be maintained over much longer time-periods in the embolized region, which is assumed to be beneficial in inhibiting normally occurring inflammatory reaction and the subsequent revascularization; responsible for treatment failure when definitive occlusion is required.

show abstract

“…Surface morphology is a crucial property for microspheres/nanoparticles, given that in vitro release experiments have shown that the initial burst from a smooth surface is less than that from a rough surface. 40 …”

Section: Preparation and Characterization Of Bbf-loaded Plla Nanopartmentioning

confidence: 99%

Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Cheng¹,

Wu²,

Gao³

et al. 2012

IJN

View full text Add to dashboard Cite

Background: Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro. Methods: BBF-loaded PLLA nanoparticles were prepared using the emulsion solventevaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium. Results: The BBF-loaded PLLA nanoparticles had a small particle size (408 ± 14 nm), a low polydispersity index (0.140 ± 0.008), a high encapsulation efficiency (72.44% ± 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours. Conclusion:The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.

show abstract

Surface morphology control of polylactide microspheres enclosing irinotecan hydrochloride

Cited by 23 publications

References 14 publications

Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38

Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38

Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy

Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Contact Info

Product

Resources

About