Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

“…showing higher plasma concentration in Wistar rats than free SN-38, and superior body distribution [503].…”

Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38

“…Encapsulating SN38 in poly-lactide-co-glycolic acid (PLGA) nanoparticles by emulsification/solvent evaporation method has considerably improved the stability of the lactone form [70]. One of the proposed mechanisms was that polymeric nanoparticles act as the drug reservoir in which SN38 was present in the lactone form due to the absence of water in the core and from which SN38 is released in a sustained manner.…”

The Application of Nanotechnology in Developing Talaromyces Flavus Formulations

“…Among them, we have the polymerization method, which is one of the quickest methods, in which continuous aqueous phase is mixed with continuous organic phase (Kirthi et al, 2011). Also, we have the methods of conservation and ion gelling using biodegradable hydrophilic polymers such as chitosan, gelatin, and sodium alginate, which is in fact, a mixture of two aqueous phases placed in a polymeric phase such as chitosan and sodium alginate, and in this method positive charge in a polymer with cross negative charge is mixed with the links such as sodium triphosphate or calcium chloride, and form capsules (Ebrahimnejad et al, 2011).…”