Surface Morphology Change of Polylactide Microspheres Enclosing Irinotecan Hydrochloride and Its Effect on Release Properties

Yoshizawa, Hidekazu; Nishino, Satoru; Natsugoe, Shoji; Aiko, Takashi; Kitamura, Yoshiro

doi:10.1252/jcej.36.1206

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…In the present study, we prepared polylactide (PLA)‐based microspheres enclosing acetamiprid by utilizing solvent evaporation method via emulsion. The emulsion system has the potential to obtain polymer supports (microspheres) with more narrow range of the size without sieving compared to the report described earlier,1 which is essential to control release rate of enclosed pesticide 6–8. We used oil‐in‐oil (O/O) type emulsion system for the microsphere preparation.…”

Section: Introductionmentioning

confidence: 99%

Preparation of polylactide‐based microspheres enclosing acetamiprid and evaluation of efficacy against cotton aphid by soil application

Takei

Yoshida

Hatate

et al. 2008

J of Applied Polymer Sci

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Concern for the environment has increased interest in reducing the amount of pesticides applied to agricultural land. This can be accomplished by immobilization of the pesticides in polymer supports, which prevents volatilization, degradation and leaching losses, and provides controlled release of the pesticides. In the present study, acetamiprid, a novel pesticide, was enclosed in polylactide (PLA)-based microspheres using solvent evaporation method via oil-in-oil (O/O) emulsion. Amount of acetamiprid released from PLA microspheres was less than 5% in phosphate buffered saline. On the other hand, incorporation of water-soluble polymer, such as poly(ethylene glycol) (PEG) and poly(oxyethylene) diglycolic acid, into the PLA microspheres resulted in increased amount of released acetamiprid ( 70%). Planting hole application by greenhouse pot test demonstrated that the efficacy of the PLA/PEG microspheres enclosing acetamiprid against cotton aphids was superior to that of PLA microspheres enclosing acetamiprid.

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Section: Introductionmentioning

confidence: 99%

Preparation of polylactide‐based microspheres enclosing acetamiprid and evaluation of efficacy against cotton aphid by soil application

Takei

Yoshida

Hatate

et al. 2008

J of Applied Polymer Sci

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“…T g decreased further when the concentration of nickel ferrite particles increased from 0.6 to 3.0% (w/v). Lower T g of PLA composites compared with pure PLA had been reported before 31, 32. In the reported system containing irinotecan hydrochloride particles (antitumor agent) and PLA, two glass transitions were found.…”

Section: Resultsmentioning

confidence: 57%

Effects of oleic acid surface coating on the properties of nickel ferrite nanoparticles/PLA composites

Yin

Chow

2008

J Biomedical Materials Res

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Nickel ferrite nanoparticles with or without oleic acid surface coating were mixed with poly(D,L-lactide) (PLA) by double emulsion method. If the nanoparticles were prepared without oleic acid coating, they adsorbed on the PLA surface. If the nanoparticles were coated with oleic acid, they could be readily encapsulated within the PLA microspheres. A slight depression in glass transition temperature was found in all composites and it could be related to the interfacial energies between nanoparticles and PLA. Optimum mixed composite was achieved by reducing interfacial energy. However, loading capacity was limited in this composite. Increasing the amount of nickel ferrite nanoparticles was not useful to increase loading capacity. Cytotoxicity of the composite decreased significantly when nickel ferrite nanoparticles were effectively encapsulated in PLA microspheres.

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“…Antitumor agents, proteins, peptides, vaccines, and genes have all been microencapsulated in PLA microcapsules. Nevertheless, our previous reports indicated that PLA microcapsules can not perfectly control the release rate of antitumor agents 8–10. Furthermore, Crotts et al reported that protein adsorption on the surface of poly( DL ‐lactide‐ co ‐glycolide) microspheres caused the uncontrollable release rate of proteins 11…”

Section: Introductionmentioning

confidence: 99%

“…microcapsules can not perfectly control the release rate of antitumor agents. [8][9][10] Furthermore, Crotts et al reported that protein adsorption on the surface of poly(DL-lactide-coglycolide) microspheres caused the uncontrollable release rate of proteins. [11] Non-ionic surfactants, such as poloxamer, polysorbate, and sorbitan monooleate, have frequently been used for the emulsification of aqueous and organic phases during the fabrication process of microspheres.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Interfacial Properties of a Novel Biodegradable Polymer Surfactant: Poly(ethylene oxide monooleate‐block‐DL‐lactide)

Nishino

Kitamura

Kishida

et al. 2005

Macromolecular Bioscience

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In this paper, we report a novel synthesis of poly(ethylene oxide monooleate-block-DL-lactide) (MOPEO-PLA) in the presence of stannous 2-ethylhexanoate catalyst. By utilizing the surfactant property and the reactive double bond of the amphiphilic MOPEO-PLA, various characteristics of PLA microspheres, such as surface and internal structure, surface morphology, release property, and so on, may potentially be controlled. MOPEO-PLA was found to be hydrophobic enough to prevent loss by dissolution into aqueous solution, which is often a problem for MOPEO. Furthermore, the interfacial tension measurements of a MOPEO-PLA/toluene/water system revealed that MOPEO-PLA had a good surface activity almost equal to that of MOPEO. The MOPEO-PLA/PLA blend films were prepared by solvent casting on a water layer. Contact-angle measurements of MOPEO-PLA/PLA blend films confirmed that the hydrophilic PEO segments were selectivity accumulated at the oil/water interface. Moreover, the surface free energy on the 'water side' of the MOPEO-PLA/PLA blend films was increased because of the increase in polar components as a result of the ether bonds of the PEO segments. Schematic illustration of the adsorption property of a) MOPEO-PLA with a high-molecular-weight PLA segment and b) MOPEO-PLA with a low-molecular-weight PLA segment at an ethyl acetate/water interface.

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Surface Morphology Change of Polylactide Microspheres Enclosing Irinotecan Hydrochloride and Its Effect on Release Properties

Cited by 7 publications

References 18 publications

Preparation of polylactide‐based microspheres enclosing acetamiprid and evaluation of efficacy against cotton aphid by soil application

Preparation of polylactide‐based microspheres enclosing acetamiprid and evaluation of efficacy against cotton aphid by soil application

Effects of oleic acid surface coating on the properties of nickel ferrite nanoparticles/PLA composites

Preparation and Interfacial Properties of a Novel Biodegradable Polymer Surfactant: Poly(ethylene oxide monooleate‐block‐DL‐lactide)

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