Surface modified PAMAM dendrimers with gallic acid inhibit, cell proliferation, cell migration and inflammatory response to augment apoptotic cell death in human colon carcinoma cells

Priyadarshi, Khushbu; Shirsath, Kavita; Waghela, N. Bhargav; Sharma, Anupama; Kumar, Ajay; Pathak, Chandramani

doi:10.1080/07391102.2020.1802344

Cited by 20 publications

(6 citation statements)

References 32 publications

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“…The reduction of cytotoxicity of the GA component on GA-PEPE stems from the modifying effect of the carboxyl group. The GA-modified PAMAM nanoparticles exhibit the same toxicity modifying effect . Although biocompatible PPC with superior biocompatibility was used to synthesize PEPE nanoparticles, the cytotoxicity originating from PEI cannot be ignored.…”

Section: Resultsmentioning

confidence: 99%

“…The GA-modified PAMAM nanoparticles exhibit the same toxicity modifying effect. 68 Although biocompatible PPC with superior biocompatibility was used to synthesize PEPE nanoparticles, the cytotoxicity originating from PEI cannot be ignored. The hydrophilic PEI chain segments, the “shells” of the nanoparticles, exhibit cytotoxicity due to the highly positively charged structure of the surface.…”

Section: Resultsmentioning

confidence: 99%

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Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Xie,

Gao,

Liu

et al. 2024

ACS Omega

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The aim of the research was to develop novel gallic acid (GA)-modified amphiphilic nanoparticles of polyethylenimine (PEI)−polypropylene carbonate (PPC)−PEI (PEPE) and comprehensively assess its properties as an antiperiodontitis nanoparticle targeting the Toll-like receptor (TLR). The first step is to evaluate the binding potential of GA to the core trigger receptors TLR2 and TLR4/MD2 for periodontitis using molecular docking techniques. Following this, we conducted NMR, transmission electron microscopy, and dynamic light scattering analyses on the synthesized PEPE nanoparticles. As the final step, we investigated the synthetic results and in vitro antiperiodontitis properties of GA-PEPE nanoparticles. The investigation revealed that GA exhibits potential for targeted binding to TLR2 and the TLR4/MD2 complex. Furthermore, we successfully developed 91.19 nm positively charged PEPE nanoparticles. Spectroscopic analysis indicated the successful synthesis of GA-modified PEPE. Additionally, CCK8 results demonstrated that GA modification significantly reduced the biotoxicity of PEPE. The in vitro antiperiodontitis properties assessment illustrated that 6.25 μM of GA-PEPE nanoparticles significantly reduced the expression of pro-inflammatory factors TNF-α, IL-1β, and IL-6. The GA-PEPE nanoparticles, with their targeted TLR binding capabilities, were found to possess excellent biocompatibility and antiperiodontitis properties. GA-PEPE nanoparticles will provide highly innovative input into the development of anti-periodontitis nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Xie,

Gao,

Liu

et al. 2024

ACS Omega

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“…PAMAM G4 dendrimers can increase the bioavailability of GA and its antitumor activity against colon cancer cells HCT116. Its mechanism is to increase the uptake of GA [ 79 ]. At the same time, dendrimers target the release of GA and play a synergistic role with anticancer drugs [ 80 ].…”

Section: Polyphenolic Compoundsmentioning

confidence: 99%

Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products

Deng

Wang

et al. 2023

Polymers

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Natural products have proven their value as drugs that can be therapeutically beneficial in the treatment of various diseases. However, most natural products have low solubility and poor bioavailability, which pose significant challenges. To solve these issues, several drug nanocarriers have been developed. Among these methods, dendrimers have emerged as vectors for natural products due to their superior advantages, such as a controlled molecular structure, narrow polydispersity index, and the availability of multiple functional groups. This review summarizes current knowledge on the structures of dendrimer-based nanocarriers for natural compounds, with a particular focus on applications in alkaloids and polyphenols. Additionally, it highlights the challenges and perspectives for future development in clinical therapy.

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“…Firstly, a sustained release of gallic acid was remarked during the payload, appended with higher cellular uptake. In addition, the in vitro evaluations showed the downregulation of inflammatory markers NG-kB, IL-1β, and IL-6, when treated with the said nanocarrier [ 147 ]. Similar effects were found when using gallic acid as a stabilizer of tungsten-based polyxomerates nanocluster (W-POM NCs) in the DSS-induced colitis model [ 148 ].…”

Section: Designed Polyphenolic-loaded Nanocarriers For Inflammation-m...mentioning

confidence: 99%

Modulating Inflammation-Mediated Diseases via Natural Phenolic Compounds Loaded in Nanocarrier Systems

2023

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The global increase and prevalence of inflammatory-mediated diseases have been a great menace to human welfare. Several works have demonstrated the anti-inflammatory potentials of natural polyphenolic compounds, including flavonoid derivatives (EGCG, rutin, apigenin, naringenin) and phenolic acids (GA, CA, etc.), among others (resveratrol, curcumin, etc.). In order to improve the stability and bioavailability of these natural polyphenolic compounds, their recent loading applications in both organic (liposomes, micelles, dendrimers, etc.) and inorganic (mesoporous silica, heavy metals, etc.) nanocarrier technologies are being employed. A great number of studies have highlighted that, apart from improving their stability and bioavailability, nanocarrier systems also enhance their target delivery, while reducing drug toxicity and adverse effects. This review article, therefore, covers the recent advances in the drug delivery of anti-inflammatory agents loaded with natural polyphenolics by the application of both organic and inorganic nanocarriers. Even though nanocarrier technology offers a variety of possible anti-inflammatory advantages to naturally occurring polyphenols, the complexes’ inherent properties and mechanisms of action have not yet been fully investigated. Thus, expanding the quest on novel natural polyphenolic-loaded delivery systems, together with the optimization of complexes’ activity toward inflammation, will be a new direction of future efforts.

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Surface modified PAMAM dendrimers with gallic acid inhibit, cell proliferation, cell migration and inflammatory response to augment apoptotic cell death in human colon carcinoma cells

Cited by 20 publications

References 32 publications

Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products

Modulating Inflammation-Mediated Diseases via Natural Phenolic Compounds Loaded in Nanocarrier Systems

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