Surface Modifications of Dental Ceramic Implants with Different Glass Solder Matrices:<i>In Vitro</i>Analyses with Human Primary Osteoblasts and Epithelial Cells

Markhoff, Jana; Mick, Enrico; Mitrovic, Aurica; Pasold, Juliane; Wegner, Katharina; Bader, Rainer

doi:10.1155/2014/742180

Cited by 14 publications

(18 citation statements)

References 30 publications

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“…Currently, zirconia is a clinically applied material for dental implants. There have been many studies in the past, and improvements in physical properties, osseointegration, and clinical application have been made [95–97]. These clinical applications have been made, and there have been reports of clinical prognosis after use [95, 96].…”

Section: Discussionmentioning

confidence: 99%

“…There have been many studies in the past, and improvements in physical properties, osseointegration, and clinical application have been made [95–97]. These clinical applications have been made, and there have been reports of clinical prognosis after use [95, 96]. Pierall et al [98] investigated about 347 cases and reported a 95.6% survival rate after a 1-year follow-up in 2016.…”

Section: Discussionmentioning

confidence: 99%

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General review of titanium toxicity

et al. 2019

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Background Titanium is a commonly used inert bio-implant material within the medical and dental fields. Although the use of titanium is thought to be safe with a high success rate, in some cases, there are rare reports of problems caused by titanium. In most of these problematic reports, only individual reports are dominant and comprehensive reporting has not been performed. This comprehensive article has been prepared to review the toxicity of titanium materials within the medical and dental fields. Methods We used online searching tools including MEDLINE (PubMed), Embase, Cochrane Library, and Google Scholar by combining keywords such as “titanium implant toxicity,” “titanium implant corrosion,” “titanium implant allergy,” and “yellow nail syndrome.” Recently updated data has been collected and compiled into one of four categories: “the toxicity of titanium,” “the toxicity of titanium alloys,” “the toxicity of titanium implants,” and “diseases related to titanium.” Results Recent studies with regard to titanium toxicity have been increasing and have now expanded to the medical field in addition to the fields of environmental research and basic science. Problems that may arise in titanium-based dental implants include the generation of titanium and titanium alloy particles and ions deposited into surrounding tissues due to the corrosion and wear of implants, resulting in bone loss due to inflammatory reactions, which may lead to osseointegration failure of the dental implant. These titanium ions and particles are systemically deposited and can lead to toxic reactions in other tissues such as yellow nail syndrome. Additionally, implant failure and allergic reactions can occur due to hypersensitivity reactions. Zirconia implants can be considered as an alternative; however, limitations still exist due to a lack of long-term clinical data. Conclusions Clinicians should pay attention to the use of titanium dental implants and need to be aware of the problems that may arise from the use of titanium implants and should be able to diagnose them, in spite of very rare occurrence. Within the limitation of this study, it was suggested that we should be aware the rare problems of titanium toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

General review of titanium toxicity

et al. 2019

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“…Titanium and titanium alloys with roughened surface are widely used in dental and orthopaedic replacement surgery (Markhoff et al. ). As blood clot formation is the start of the healing process, the interaction between implant and blood is considered as one of the most important factors for the successful osseointegration of titanium implants after implantation (Shiu et al.…”

Section: Discussionmentioning

confidence: 99%

Blood clot formed on rough titanium surface induces early cell recruitment

Yang

Zhou

Wei

et al. 2015

Clinical Oral Implants Res

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“…As Markhoff et al [ 23 ] also reported about their WST-results, the sample revealed significantly lower extinction values than the controls at each time point. When considering the cause of this superiority over the controls, one needs to keep in mind that the Thermanox membranes we used have a larger surface but we were working with the same number of cells.…”

Section: Discussionmentioning

confidence: 51%

“…The WST-1 assay tests the respiratory chain via the mitochondrial succinate-tetrazolium-dehydro-genase system. This allow to assess the cells’ metabolic activity and is often used to investigate proliferation when testing the biocompatibility of novel materials [ 23 , 24 ]. Figure 6 demonstrates that both MG 63 and OB proliferated evenly on the samples.…”

Section: Resultsmentioning

confidence: 99%

Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties

et al. 2018

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Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine. The aim of this investigation was to test the suitability of C/SiSiC ceramics as a new material for bearing couples in endoprosthetics. After the preparation of the composites flexural strength was determined as well as the Young’s-modulus and the coefficient of friction. To investigate in vitro biological properties, MG 63 and primary human osteoblasts were cultured on C/SiSiC composites. To review the proliferation, the cytotoxicity standardized tests were used. The cell morphology was observed by light microscopy, ESEM, confocal and 3D-laserscanning microscopy. C/SiSiC possesses a high resistance to wear. Cells exhibited no significant alterations in morphology. Vitality was not impaired by contact with the ceramic composite. There was no higher cytotoxicity to observe. Regarding these results, C/SiSiC ceramics seem to be biologically and mechanically appropriate for orthopaedic applications.

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Surface Modifications of Dental Ceramic Implants with Different Glass Solder Matrices:In VitroAnalyses with Human Primary Osteoblasts and Epithelial Cells

Cited by 14 publications

References 30 publications

General review of titanium toxicity

General review of titanium toxicity

Blood clot formed on rough titanium surface induces early cell recruitment

Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties

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