Blood clot formed on rough titanium surface induces early cell recruitment

Yang, Jin; Zhou, Yinghong; Wei, Fei; Xiao, Yin

doi:10.1111/clr.12672

Cited by 42 publications

(28 citation statements)

References 45 publications

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“…The beneficial effect we observe here with the BRB is likely due to the fact that blood clot is a natural protein hydrogel known for its regenerative properties in wound healing. Moreover the blood clot brings the regenerative potential of blood cells such as monocytes and platelets . This is supported by our previous data, which have shown in vitro that BCP microparticles induce monocyte proliferation and activation …”

Section: Discussionsupporting

confidence: 84%

Combination of blood and biphasic calcium phosphate microparticles for the reconstruction of large bone defects in dog: A pilot study

Balaguer

Fellah²,

Boukhechba

et al. 2018

J Biomedical Materials Res

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We previously reported that biphasic calcium phosphate (BCP) microparticles embedded in a blood clot induces ectopic bone formation in mice and repairs a critical femoral defect in rat. The present pilot study aimed to evaluate in dog and in two models of large defects the efficacy of this composite named "blood for reconstruction of bone" (BRB). We show here that BRB is a cohesive biomaterial easy to prepare from dog autologous blood and to mold to fill large bone defects. First in a model of cylindrical femoral condyle defect, the BRB was compared with BCP particles alone. After 8 weeks, this revealed that the amount of mature bone was slightly and significantly higher with BRB than with BCP particles. Second, in a model consisting in a 2 cm-long critical interruptive defect of the ulna, the BRB was compared with autologous bone. After 6 months, we observed that implantation of BRB can induce the complete reconstruction of the defect and that newly formed bone exhibits high regenerative potential. Comparison with the results obtained with autologous bone grafting strongly suggests that the BRB might be an efficient biomaterial to repair large bone defects, as an alternative or in addition to autologous bone. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1842-1850, 2018.

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Section: Discussionsupporting

confidence: 84%

Combination of blood and biphasic calcium phosphate microparticles for the reconstruction of large bone defects in dog: A pilot study

Balaguer

Fellah²,

Boukhechba

et al. 2018

J Biomedical Materials Res

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“…This phenomenon is due to the reduction of space for bone formation since it is occupied by the remnants of biomaterials 16,17 , an event confirmed by this study. In addition, the coagulum presents growth factors that accelerate bone regeneration 18,19 . However, it is worth mentioning that the COA group had a lower volume of MT, which demonstrates that the use of biomaterials is important to obtain sufficient repair tissue availability to maintain or to improve the bone morphology 14,20 .…”

Section: Discussionmentioning

confidence: 99%

Bone repair induced by different bone graft substitutes in critical-sized defects in rat calvaria

Aroni

Neto

Oliveira

et al. 2019

Rev. odontol. UNESP

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Introduction The use of bone substitutes in grafting procedures as an alternative of the use of autogenous bone graft has been indicated, however, the direct comparison between these biomaterials has been little explored. Objective To evaluate the effect of different osteoconductive bone substitutes on the bone repair in critical-sized defects (CSDs) in rat calvaria. Material and method One CSD with an 8 mm diameter was made in each of the 40 rats used in this study. The animals were randomly allocated into 5 groups (n=8), according to the type of bone substitute used to fill the CSD: COA (Coagulum); AUT (autogenous bone); DBB (deproteinized bovine bone graft); HA/TCP (biphasic ceramic composed of hydroxyapatite and β-phosphate tricalcium); and TCP (β-phosphate tricalcium). A microtomographic analysis was performed to evaluate the remaining defect linear length (DLL) of the CSD and the volume of the mineralized tissues (MT) within the CSD at 3, 7, 15 and 30 days after the surgical procedure. In addition, a histometric analysis was performed to evaluate the composition of the repaired bone tissue (% Bone and % Biomaterial) at the 30-day period. Result It was shown that the COA had the lowest DLL and MT within the CSD. In addition, the COA presented the highest % of bone in CSD. The DBB had a higher MT and a higher % of bone substitute particles in the CSD than the AUT and TCP groups. The DBB and AUT groups presented higher % of bone in the CSD than the TCP group. Conclusion The use of the DBB promoted a better pattern of bone volume gain and formation compared to TCP and HA / TCP but was biologically inferior to the AUT.

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“…This may induce early recruitment of cells, which will enhance the wound healing (Yang et al. ). It can be speculated from the results of the SEM investigation that the domes with a rough inner surface possess a stronger bond to the new bone.…”

Section: Discussionmentioning

confidence: 99%

The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes

Anderud

Jimbo

Abrahamsson

et al. 2015

Clinical Oral Implants Res

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Blood clot formed on rough titanium surface induces early cell recruitment

Abstract: Rough titanium surfaces could influence the blood clot formation and properties, which will induce cell recruitment and stimulate wound healing.

Cited by 42 publications

References 45 publications

Combination of blood and biphasic calcium phosphate microparticles for the reconstruction of large bone defects in dog: A pilot study

Combination of blood and biphasic calcium phosphate microparticles for the reconstruction of large bone defects in dog: A pilot study

Bone repair induced by different bone graft substitutes in critical-sized defects in rat calvaria

The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes

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