Surface modification techniques of titanium and titanium alloys for biomedical orthopaedics applications: A review

Han, Xiaobin; Ma, Jianxiong; Yan, Wei; Li, Yan; Dong, Benchao; Xue, Tong; Ma, Xinlong

doi:10.1016/j.colsurfb.2023.113339

Cited by 55 publications

(16 citation statements)

References 156 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various surface treatment methods have been used to optimize the surface of titanium implants, including electrochemical anodization, template methods, and hydrothermal methods (Jemat et al, 2015;Han et al, 2023). Anodic oxidation is an electrochemical treatment method that can produce nanotube morphologies on the surface of materials such as Ti, Zr, and C (Minagar et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Fabrication and surface characterization of titanium dioxide nanotubes on titanium implants

Zheng,

Xu,

Jiao

et al. 2023

Front. Mater.

View full text Add to dashboard Cite

Titanium has been widely used in orthopedics and dental implants due to its excellent biocompatibility and mechanical properties. However, the surface of titanium is biologically inert and lacks biological activity, resulting in poor integration between titanium-based implants and surrounding natural bone tissue, which is a common challenge in its clinical application. Surface modification is currently an effective means to improve the biocompatibility and bioactivity of titanium implants. The natural tissues of the human body are assembled from nanomodules, so from a biomimetic perspective, nanostructures should have better biological activity. TiO2 nanotubes have unique physical and chemical properties due to their elastic modulus, large specific surface area, and regular hollow structure similar to those of bone tissue. This study used anodic oxidation technology to prepare TiO2 nanotubes on the surface of titanium. The surface properties of the nanotubes were evaluated using field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), atomic force microscopy profilometry, contact angle measurements, etc. The corrosion resistance was tested using an electrochemical workstation. The results indicate that anodic oxidation can be used to successfully prepare titanium dioxide nanotube arrays on the surface of titanium. The nanotubes not only exhibit a good structure but also improve the surface hydrophilicity and corrosion resistance of titanium, thereby demonstrating potential for clinical application.

show abstract

Section: Introductionmentioning

confidence: 99%

Fabrication and surface characterization of titanium dioxide nanotubes on titanium implants

Zheng,

Xu,

Jiao

et al. 2023

Front. Mater.

View full text Add to dashboard Cite

show abstract

“…Additional considerations include the nature and texture of the implant. The increasing application of titanium in dental implant is due to multiple beneficial effects [ 35 , 36 ]. To overcome titanium bio-inertness in dental implant procedures, subtractive or additive surface modification methods are commonly implemented to create nano- or micro-scale structures and promote osseointegration [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Herein, we can deeply explore the detailed mechanism and involved molecules that participate in the regulation of osteointegration. In a stage earlier than osteointegration, the mesenchymal fibroblast-like cell and endothelial play crucial roles in angiogenesis during implant implantation immediately [ 36 ]. After the stable stage, the antibacterial ability in processing implants can help to eliminate the possibility of peri-implantitis [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Titanium Surfaces with a Laser-Produced Microchannel Structure Enhance Pre-Osteoblast Proliferation, Maturation, and Extracellular Mineralization In Vitro

Chen,

Chiang,

Chen

et al. 2024

IJMS

View full text Add to dashboard Cite

The clinical success of dental titanium implants is profoundly linked to implant stability and osseointegration, which comprises pre-osteoblast proliferation, osteogenic differentiation, and extracellular mineralization. Because of the bio-inert nature of titanium, surface processing using subtractive or additive methods enhances osseointegration ability but limits the benefit due to accompanying surface contamination. By contrast, laser processing methods increase the roughness of the implant surface without contamination. However, the effects of laser-mediated distinct surface structures on the osteointegration level of osteoblasts are controversial. The role of a titanium surface with a laser-mediated microchannel structure in pre-osteoblast maturation remains unclear. This study aimed to elucidate the effect of laser-produced microchannels on pre-osteoblast maturation. Pre-osteoblast human embryonic palatal mesenchymal cells were seeded on a titanium plate treated with grinding (G), sandblasting with large grit and acid etching (SLA), or laser irradiation (L) for 3–18 days. The proliferation and morphology of pre-osteoblasts were evaluated using a Trypan Blue dye exclusion test and fluorescence microscopy. The mRNA expression, protein expression, and protein secretion of osteogenic differentiation markers in pre-osteoblasts were evaluated using reverse transcriptase quantitative polymerase chain reaction, a Western blot assay, and a multiplex assay, respectively. The extracellular calcium precipitation of pre-osteoblast was measured using Alizarin red S staining. Compared to G- and SLA-treated titanium surfaces, the laser-produced microchannel surfaces enhanced pre-osteoblast proliferation, the expression/secretion of osteogenic differentiation markers, and extracellular calcium precipitation. Laser-treated titanium implants may enhance the pre-osteoblast maturation process and provide extra benefits in clinical application.

show abstract

“…Surface strengthening treatment is an effective technical means to improve the tribocorrosion resistance of titanium alloy. Many surface treatment technologies are applicable for enhancing the feeling of titanium alloy [ 27 , 142 , 143 , 144 ]. The application and development of titanium surface treatment technology have gone through three stages: The first stage is the traditional surface technology represented by electroplating, electroless plating, and thermal diffusion (nitriding, carburizing, etc.).…”

Section: Surface Modification Methodsmentioning

confidence: 99%

Tribocorrosion and Surface Protection Technology of Titanium Alloys: A Review

Li,

Zhou,

2023

Materials

View full text Add to dashboard Cite

Titanium alloy has the advantages of high specific strength, good corrosion resistance, and biocompatibility and is widely used in marine equipment, biomedicine, aerospace, and other fields. However, the application of titanium alloy in special working conditions shows some shortcomings, such as low hardness and poor wear resistance, which seriously affect the long life and safe and reliable service of the structural parts. Tribocorrosion has been one of the research hotspots in the field of tribology in recent years, and it is one of the essential factors affecting the application of passivated metal in corrosive environments. In this work, the characteristics of the marine and human environments and their critical tribological problems are analyzed, and the research connotation of tribocorrosion of titanium alloy is expounded. The research status of surface protection technology for titanium alloy in marine and biological environments is reviewed, and the development direction and trends in surface engineering of titanium alloy are prospected.

show abstract

Surface modification techniques of titanium and titanium alloys for biomedical orthopaedics applications: A review

Cited by 55 publications

References 156 publications

Fabrication and surface characterization of titanium dioxide nanotubes on titanium implants

Fabrication and surface characterization of titanium dioxide nanotubes on titanium implants

Titanium Surfaces with a Laser-Produced Microchannel Structure Enhance Pre-Osteoblast Proliferation, Maturation, and Extracellular Mineralization In Vitro

Tribocorrosion and Surface Protection Technology of Titanium Alloys: A Review

Contact Info

Product

Resources

About