Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Pavlović, Marko; Szerlauth, Adél; Muráth, Szabolcs; Varga, Gábor; Szilágyi, István

doi:10.1016/j.addr.2022.114590

Cited by 31 publications

(22 citation statements)

References 224 publications

(329 reference statements)

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“…This exchangeability increases by increasing the charge of the incoming anion and by decreasing its ionic radius [17]. Moreover, when bio-active compounds are involved, interfacial interaction between the hosting structure and the guest molecule, i.e., adsorption on either the outer surface or within the layers, occurs [23]; therefore, exchanging anions can also substitute the enzyme through surface interactions. Zou and Planck [8,9] reported the use of Na 2 SO 4 0.08 M for the release of cellulase from LDH.…”

Section: Effect Of Medium On the Release Of Enzyme From The Ldh Struc...mentioning

confidence: 99%

Triggering of Polymer-Degrading Enzymes from Layered Double Hydroxides for Recycling Strategies

Romano

Rosato

Bianchi

et al. 2023

IJMS

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The use of degrading enzymes in polymer formulation is a very attractive strategy to manage the end-of-life of plastics. However, high temperatures cause the denaturation of enzymes and the loss of their catalytic activity; therefore, protection strategies are necessary. Once protected, the enzyme needs to be released in appropriate media to exert its catalytic activity. A successful protection strategy involves the use of layered double hydroxides: cutinase, selected as a highly degrading polyester hydrolytic enzyme, is thermally protected by immobilization in Mg/Al layered double hydroxide structures. Different triggering media are here evaluated in order to find the best releasing conditions of cutinase from LDH. In detail, phosphate and citrate–phosphate buffers, potassium carbonate, sodium chloride, and sodium sulfate solutions are studied. After the comparison of all media in terms of protein release and activity retained, phosphate buffer is selected as the best candidate for the release of cutinase from LDH, and the effect of pH and concentration is also evaluated. The amount of the enzyme released is determined with the Lowry method. Activity tests are performed via spectrophotometry.

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Section: Effect Of Medium On the Release Of Enzyme From The Ldh Struc...mentioning

confidence: 99%

Triggering of Polymer-Degrading Enzymes from Layered Double Hydroxides for Recycling Strategies

Romano

Rosato

Bianchi

et al. 2023

IJMS

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“…The surface modification of LDH by polymers is an important strategy for their application in the pharmaceutical field owing to the enhancement of key characteristics of these hybrids, such as improved stability, biocompatibility, dispersity, cellular uptake and decrease in systemic toxicity [ 52 , 157 , 158 ]. The interaction process of organic molecules and the surfaces of LDH particles can involve different regions of the inorganic phase, such as the interlayer space and/or the external surface [ 159 ]. However, methodologies involving mainly the interaction of polymers with the outer surface of the LDH phase allow a larger uptake of a certain bioactive compound, which could benefit drug delivery applications, for instance [ 160 ].…”

Section: Layered Double Hydroxides: Structure Physicochemical Propert...mentioning

confidence: 99%

“…However, methodologies involving mainly the interaction of polymers with the outer surface of the LDH phase allow a larger uptake of a certain bioactive compound, which could benefit drug delivery applications, for instance [ 160 ]. Such interaction between the LDH surface and a polymer or a therapeutic agent occurs primarily through Coulombic interaction caused by the positively charged layers of the inorganic phase [ 159 , 161 ], which can be optimized when the organic species have negatively charged groups within their structures. However, a large variety of organic molecules are neutral or do not possess significant hydrophilic portions to interact with the hydroxylated surface of LDH, which can cause poor compatibility between both phases [ 162 ] and, consequently, worsen several physical properties of the composite.…”

Section: Layered Double Hydroxides: Structure Physicochemical Propert...mentioning

confidence: 99%

“…Using a similar approach, Wen et al [ 191 ] prepared a carrier constituted by stratified layers of CoAl-LDH and MnO 2 conjugated with folic acid. More details about the application of LDH as a carrier in theragnostic agents are reported in review works [ 159 , 172 , 192 , 193 , 194 ].…”

Section: Layered Double Hydroxides: Structure Physicochemical Propert...mentioning

confidence: 99%

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Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

et al. 2023

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The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery) and tissue engineering (skin and bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between the layers. The layers can hold metal cations that confer intrinsic biological activity to LDHs as well as biocompatibility. The intercalation of bioactive species between the layers allows the formation of drug delivery systems with elevated loading capacity and modified release profiles promoted by ion exchange and/or solubilization. The capacity of tissue integration, antigenicity, and stimulation of collagen formation, among other beneficial characteristics of LDH, have been observed by in vivo assays. The association between the properties of biocompatible polymers and LDH-drug nanohybrids produces multifunctional nanocomposites compatible with living matter. Such nanocomposites are stimuli-responsive, show appropriate mechanical properties, and can be prepared by creative methods that allow a fine-tuning of drug release. They are processed in the end form of films, beads, gels, monoliths etc., to reach orientated therapeutic applications. Several studies attest to the higher performance of polymer/LDH-drug nanocomposite compared to the LDH-drug hybrid or the free drug.

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“…n H 2 O, where M(II) and M(III) are metal cations and A is an anion in the interlayer (Zhang et al, 2023) . LDH can be synthesized by various methods including sol-gel, hydrothermal, and coprecipitation methods (Pavlovic et al, 2022;Valeikiene et al, 2019). However, among these methods, the coprecipitation method is the most commonly used method because of the ease of the process and the ease of control such as pH parameters during the synthesis process (Wang et al, 2022) .…”

Section: Introductionmentioning

confidence: 99%

Malachite Green Dye Adsorption from Aqueous Solution using a Ni/Al Layered Double Hydroxide-Graphene Oxide Composite Material

Amri

Lesbani

Mohadi

2023

Sci. Technol. Indones

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Ni/Al layered double hydroxide and Ni/Al-graphene oxide composite materials were created using the coprecipitation method. The materials were successfully synthesized and prepared using XRD, FT-IR, and BET studies. The optimal pH as a result of malachite green dye adsorption is pH 4. The kinetics models of all materials follow the pseudo second order model. After being composited with graphene oxide, the maximum adsorption capacity of Ni/Al layered double hydroxide increased from 99.010 to 111.111 mg/g. All materials’ isotherm models adhere to the Langmuir isotherm model. The adsorption process was endothermic and spontaneous. The Ni/Al-graphene oxide composite material has a more stable structure than the Ni/Al layered double hydroxide. The regeneration procedure was repeated five times, and the Ni/Al-graphene oxide composite material did not show a significant decrease until the fifth cycle, when it dropped from 97.561 to 77.046%, however the Ni/Al layered double hydroxide material dropped rapidly from 85.00 to 5.667%.

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Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Cited by 31 publications

References 224 publications

Triggering of Polymer-Degrading Enzymes from Layered Double Hydroxides for Recycling Strategies

Triggering of Polymer-Degrading Enzymes from Layered Double Hydroxides for Recycling Strategies

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

Malachite Green Dye Adsorption from Aqueous Solution using a Ni/Al Layered Double Hydroxide-Graphene Oxide Composite Material

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