Surface modification of polytetrafluoroethylene (PTFE) with a heparin-immobilized extracellular matrix (ECM) coating for small-diameter vascular grafts applications

Yu, Chenglong; Yang, Huaguang; Wang, Lu; Thomson, James A.; Turng, Lih‐Sheng; Guan, Guoping

doi:10.1016/j.msec.2021.112301

Cited by 33 publications

(17 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Composite polymers tend to be used in cardiovascular applications [ 1 ] due to their versatility in terms of their mechanical, thermal, and physicochemical properties, which are achieved by mixing a disperse phase (filler) and a continuous phase (polymeric matrix) [ 1 , 2 ]. Several investigations with different polymeric matrices have been conducted to obtain new composite materials for cardiovascular implants, especially with alginate, poly(D,L-lactic-co-glycolic acid) (PLGA), polytetrafluoroethylene (PTEF), polyethylene terephthalate (Dacron), and polyurethane (PU) [ 3 , 4 , 5 , 6 , 7 , 8 ]. Between these polymeric matrices, polyurethanes are listed as the first candidate for the production of vascular grafts owing to their better compliance, biocompatibility, mechanical properties, and adaptation to different manufacturing technologies [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

2022

View full text Add to dashboard Cite

Improvements in the antithrombogenicity activity of biomaterials for cardiovascular applications are necessary to meet the demand for vascular grafts in the world. Zwitterionic compounds tend to be used due to their anti-fouling properties, which reduce platelet adhesions and protein absorptions. Therefore, in this research, potato starch (AL-N) and zwitterionic starch (AL-Z) (obtained by Williamson etherification) were included as fillers in polyurethane (PU) matrices from polycaprolactone diol (PCL), polyethylene glycol (PEG), pentaerythritol (PE) and isophorone diisocyanate (IPDI) in order to study their effect in terms of their physicochemical, mechanical and thermal properties. We conducted our evaluation using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), contact angle analysis, swelling behavior, thermogravimetric analysis (TGA), tensile/strain analysis, scanning electron microscopy equipped with energy dispersive X-ray spectroscopy (SEM-EDS), dynamic mechanic analysis (DMA), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The results showed that AL-N and AL-Z modified these properties, where AL-N improved tensile strength, and AL-Z increased the hydrophilicity of polyurethanes matrices; additionally, AL-N had interactions with the soft segments, and AL-Z had interactions with the hard segments. Finally, both fillers reduced the degree of crystallinity and did not affect the thermal stability of polyurethanes.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

2022

View full text Add to dashboard Cite

show abstract

“…34,35 Due to their biological inertia, these materials are prone to induce thrombosis, intimal hyperplasia, and calcification during the formation of smallcaliber vascular structures. 36 Therefore, there is a great need for functional small-caliber vascular grafts that mimic autogenous vessels without serious complications. The basic strategies of vascular tissue engineering involve the design and manufacture of scaffolds that are suited for vascular cell adhesion, proliferation, and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Construction of spider silk protein small‐caliber tissue engineering vascular grafts based on dynamic culture and its performance evaluation

Yang

et al. 2022

J Biomedical Materials Res

View full text Add to dashboard Cite

Tissue engineering is an alternative method for preparing small-caliber (<6 mm) vascular grafts. Dynamic mechanical conditioning is being researched as a method to improve mechanical properties of tissue engineered blood vessels. This method attempts to induce unique reaction in implanted cells that regenerate the matrix around them, thereby improving the overall mechanical stability of the grafts. In this

show abstract

“…The increased surface hydrophilicity was owing to the molecular structure of heparin containing a large number of hydrophilic groups such as hydroxyl, carboxyl, and sulfonic acid groups. 42 Moreover, the hydrophilicity of the PAA-treated membrane was better than the PDA-treated membrane, but the hydrophilicity of the heparinized membrane by PDA was the best. Previous studies have shown that a stable complex can be formed directly between heparin and PDA.…”

Section: Characterization Of Water Contact Anglementioning

confidence: 97%

The polydopamine‐assisted heparin anchor enhances the hydrophilicity, hemocompatibility, and biocompatibility of polyurethane

et al. 2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

Surface heparinization is an effective solution to resolve low endothelialization, poor anticoagulation, and hemocompatibility of polyurethane (PU) used as materials of small‐diameter vascular grafts. Here, the effects of polydopamine (PDA) and poly (acrylic acid) (PAA) as crosslinking agents on the surface heparinization were explored. The PU membranes grafted with heparin (Hep) via dopamine (PU/PDA‐Hep) showed better hydrophilicity and stability, compared to heparinized PU membranes via acrylic acid (PU/PAA‐Hep). The results of X‐ray photoelectron spectroscopy demonstrated that heparin was successfully grafted onto the PU surface and the grafting efficiency was high when PDA as a cross‐linking agent. The grafted heparin aggregated and formed nanoparticles, and increased the surface roughness of PU membranes. The heparinized membranes demonstrated good anti‐adhesion of bovine serum albumin and fibrin protein. In addition, no activated platelets or educts on heparinized PU were found by platelet adhesion tests, implying that heparin‐immobilized surfaces had good hemocompatibility. Moreover, the in vitro cytocompatibility assessment showed that the PU/PDA‐Hep significantly improved the proliferation of L929 cells and was superior to PU/AA‐Hep. These results demonstrated that PDA‐assisted surface heparinization was an effective method to improve the anticoagulant and biocompatibility of PU small‐diameter vascular materials and could be extended to other implantable materials.

show abstract

Surface modification of polytetrafluoroethylene (PTFE) with a heparin-immobilized extracellular matrix (ECM) coating for small-diameter vascular grafts applications

Cited by 33 publications

References 78 publications

Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

Construction of spider silk protein small‐caliber tissue engineering vascular grafts based on dynamic culture and its performance evaluation

The polydopamine‐assisted heparin anchor enhances the hydrophilicity, hemocompatibility, and biocompatibility of polyurethane

Contact Info

Product

Resources

About