Surface modification of polypropylene for enhanced layer‐by‐layer deposition of polyelectrolytes

Hachim, Daniel; Brown, Bryan N.

doi:10.1002/jbm.a.36405

Cited by 13 publications

(7 citation statements)

References 29 publications

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“…This modification led to improved drug absorption and longer release, and also imparted antibacterial properties. Plasma treatment is one of the best methods conventionally used for surface modification for inducing chemical functionality and surface charge and for increasing surface hydrophilicity [ 60 ]. Plasma-enhanced chemical vapor deposition (PECVD) was used to modify the surface of PP implants with different chemicals to produce charged PP substrates for layer-by-layer (LBL) coatings [ 60 ].…”

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

“…Plasma treatment is one of the best methods conventionally used for surface modification for inducing chemical functionality and surface charge and for increasing surface hydrophilicity [ 60 ]. Plasma-enhanced chemical vapor deposition (PECVD) was used to modify the surface of PP implants with different chemicals to produce charged PP substrates for layer-by-layer (LBL) coatings [ 60 ]. This PECVD method increased hydrophilicity and the number of functional reactive groups available for molecule grafting, and was found to be suitable for LBL deposition on PP substrates.…”

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

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Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…On the other hand, for PP modification, layer‐by‐layer plasma‐enhanced chemical vapour deposition has been successfully used to deposit hydrophilic substrates such as carboxylic acid groups from the decomposition of anhydrides, or positively charged amines. The deposited substrates in this work were crafted as polyelectrolytes to increase the hydrophilicity of the samples and to allow for further modification of the films with functional molecules (Hachim & Brown, 2018).…”

Section: Polyethylene and Polypropylenementioning

confidence: 99%

“…Some of these examples are illustrated inFigure 5.An additional example of the modification of PE was the impregnation of gentamicin-loaded chitosan onto porous UHMWPE (ultra-high-molecular-weight polyethylene) for sustain release of this drug in implants used for hip replacement (ManojKumar et al, 2017).On the other hand, for PP modification, layer-by-layer plasma-enhanced chemical vapour deposition has been successfully used to deposit hydrophilic substrates such as carboxylic acid groups from the decomposition of anhydrides, or positively charged amines. The deposited substrates in this work were crafted as polyelectrolytes to increase the hydrophilicity of the samples and to allow for further modification of the films with functional molecules(Hachim & Brown, 2018).…”

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confidence: 99%

Modification of relevant polymeric materials for medical applications and devices

Velazco‐Medel¹,

Camacho‐Cruz²,

Bucio³

2020

Med Devices & Sens

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The present review compiles different biomedical relevant polymers that have been modified to enhance their properties, giving hydrophilicity to their surfaces, antifouling properties to avoid bacterial adhesion, biocompatibility, incorporation of drug delivery systems and the improving of their mechanical properties to use them in the manufacturing of medical devices as prosthesis or implants, or other medical applications as wound dressers or scaffolds to cell culture. Other content of this work is a general description of the different techniques to modify and graft molecules, biomolecules and other polymers onto polymeric matrices in order to obtain highperformance biomaterials and medical devices.

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“…Polypropylene (PP) meshes were cleaned using a 1:1 acetone:isopropanol mixture and then air dried prior to irradiation with 15 seconds of argon plasma at 600W, an argon gas flow of 35 mL/min and a steady state pressure of 250 mTorr (50 mTorr initial pressure) using an Ion 40 Gas Plasma System (PVA Tepla America, Inc) to induce a surface charge which enabled layer by layer deposition as previously described [41]. Maleic anhydride powder (1.5 gr) was placed into a glass plate inside of the machine chamber.…”

Section: Plasma Treatment and Layer By Layer Coating Of Polypropylenementioning

confidence: 99%

Distinct release strategies are required to modulate macrophage phenotype in young versus aged animals

Hachim

Iftikhar

LoPresti

et al. 2019

Journal of Controlled Release

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The role of innate immunity and macrophages in the host response to biomaterials has received renewed attention. A context-dependent spectrum of macrophage phenotypes are shown to affect tissue integration and performance of implanted biomaterials and medical devices. Recent studies by our group demonstrated that the host response in aged animals was characterized by delayed macrophage recruitment, differences in marker expression and a shifted pro-inflammatory (M1) response, associated with an unresolved host response in the long-term. The present work sought to study the effects of single and sequential cytokine delivery regimens in aged mice to restore delayed recruitment of macrophages and shift the inflammatory host response towards an M2-like phenotype, using MCP-1 (macrophage chemotactic protein-1) and IL-4 (interleukin-4), respectively. Implantation of cytokine-eluting implants showed a preserved response to MCP-1 in both young and aged animals, restoring delayed macrophage recruitment in aged mice. However, the response elicited by IL-4, sequential delivery of MCP-1/IL-4 and coating components was distinct in young versus aged mice. While single delivery of IL-4 did not counteract the high inflammatory response observed in aged mice, the sequential delivery of MCP-1/IL-4 was capable of restoring both recruitment and shifting the macrophage response towards an M2-like phenotype, associated with decreased implant scarring in the long-term. In young mice, sequential delivery was not as effective as IL-4 alone at promoting an M2-like response, but did result in a reduction of M1 macrophages and capsule deposition downstream. These results demonstrate that a proper understanding of patient/context-dependent biological responses are needed to design biomaterialbased therapies with improved outcomes in the setting of aging.

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Surface modification of polypropylene for enhanced layer‐by‐layer deposition of polyelectrolytes

Cited by 13 publications

References 29 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

Modification of relevant polymeric materials for medical applications and devices

Distinct release strategies are required to modulate macrophage phenotype in young versus aged animals

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