Surface modification of polydimethylsiloxane microfluidic chips by polyamidoamine dendrimers for amino acid separation

Abstract

In order to improve the hydrophilicity of polydimethylsiloxane (PDMS) microfluidic chips, a series of polyamidoamine (PAMAM) dendrimers were grafted onto the PDMS pretreated by oxygen plasma and silanized with γ‐glycidoxypropyltrimethoxysilane (γ‐GPS). Fourier transformed infrared absorption by total attenuated reflection (ATR‐FTIR) and scanning electronic microscopy (SEM) showed that PAMAM dendrimers had been grafted on the PDMS surface and a dense and uniform coating was generated. The contact angle decreased from 108.1° to 31.8° compared with the unmodified PDMS, which indicated that the hydrophilicity of PDMS improved markedly. In the modified PDMS microfluidic chips, the EOF reduced obviously and the nonspecific adsorption between the amino acids and the microchannel surface was prevented effectively. The separation efficiency of arginine and phenylalanine were as high as 7.34 × 104 plates/m and 8.61 × 104 plates/m, respectively, and the resolution (RS) was 4.41. Furthermore, the reproducibility of modified chips was also very excellent, which suggested they had good stability and long service life. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43580.

The Effects of PEI Hollow Fiber Substrate Characteristics on PDMS/PEI Hollow Fiber Membranes for CO2/N2 Separation

“…The increase in CA is due to the formation of the elective PDMS layer on the outer surface of hollow fiber substrate. Our results are in agreement with the literature values of CA of PDMS membranes [ 51 , 52 , 53 , 54 ]. Knozowska et al [ 51 ] and Kujawska et al [ 52 ] found that the CA of flat sheet pristine PDMS membrane was 115°.…”

“…Knozowska et al [ 51 ] and Kujawska et al [ 52 ] found that the CA of flat sheet pristine PDMS membrane was 115°. While Khorasani et al [ 53 ] and Lin et al [ 54 ] found that the CAs of native PDMS membranes were 105° and 108°, respectively. It was reported that the wide range of CA values (95°–120°) for PDMS samples results from various experimental conditions, such as surface roughness and type of the substrate surface [ 52 ].…”

Poly(dimethylsiloxane): A Sustainable Human Skin Alternative for Transdermal Drug Delivery Prediction

“…It is also reported that tailored properties can be achieved by the judicious choice of the chemical substitute, including skin-like properties. A plethora of data have shown how PDMS possesses some intrinsic flexibilities, where modifications on the membrane can lead to an overall effect on how it works [85][86][87][88][89][90] . Interestingly, over the last decade research has been published that involves modifications carried out on the membrane which subsequently alters the permeation profile compared with the un-modified form of the membrane.…”

Polyelectrolytes layer-by-layer surface modification of PDMS microchips for the production of simple O/W and double W/O/W emulsions: From global to localized treatment

“…Nevertheless, PDMS remains the most widely used material in microfluidics owing to its flexibility and transparency in UV-Visible spectrum range. This material is hydrophobic by nature and the way to render it hydrophilic in long term is challenging, as the elastomeric property of the PDMS induces its surface recovery, hence, its hydrophobicity [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”