Polyelectrolytes layer-by-layer surface modification of PDMS microchips for the production of simple O/W and double W/O/W emulsions: From global to localized treatment

Stauffer, F. J.; Péter, Beatrix; Alem, Halima; Fünfschilling, Denis; Dumas, Norbert; Serra, Christophe A.; Roques-Carmes, Thibault

doi:10.1016/j.cep.2019.107685

Cited by 11 publications

(6 citation statements)

References 45 publications

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“…In a double emulsion, the primary emulsion (w 1 /o) is first prepared by dispersing the aqueous phase in an immiscible organic solvent containing the polymer. Subsequently, the primary emulsion is homogenized in an outer aqueous phase containing the emulsifier using a high-shear homogenizer to form the organic phase and then emulsified in the aqueous phase containing a surfactant [ 181 , 182 , 183 , 184 , 185 , 186 ].…”

Section: Methods For Producing Pnpsmentioning

confidence: 99%

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

et al. 2022

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Nanoparticles (NPs) have remarkable properties for delivering therapeutic drugs to the body’s targeted cells. NPs have shown to be significantly more efficient as drug delivery carriers than micron-sized particles, which are quickly eliminated by the immune system. Biopolymer-based polymeric nanoparticles (PNPs) are colloidal systems composed of either natural or synthetic polymers and can be synthesized by the direct polymerization of monomers (e.g., emulsion polymerization, surfactant-free emulsion polymerization, mini-emulsion polymerization, micro-emulsion polymerization, and microbial polymerization) or by the dispersion of preformed polymers (e.g., nanoprecipitation, emulsification solvent evaporation, emulsification solvent diffusion, and salting-out). The desired characteristics of NPs and their target applications are determining factors in the choice of method used for their production. This review article aims to shed light on the different methods employed for the production of PNPs and to discuss the effect of experimental parameters on the physicochemical properties of PNPs. Thus, this review highlights specific properties of PNPs that can be tailored to be employed as drug carriers, especially in hospitals for point-of-care diagnostics for targeted therapies.

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Section: Methods For Producing Pnpsmentioning

confidence: 99%

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

et al. 2022

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“…87−92 LbL coatings have been formed on silicones to modify surfaces properties, 93 with potential for superior stability versus grafted polymer chains. 94 LBL coatings are comprised of alternating layers held together by secondary forces. Most commonly, LbL coatings are formed from alternating positively and negatively charged polymers applied sequentially by dipping.…”

Section: Surface Modificationsmentioning

confidence: 99%

“…LbL coatings have been formed on silicones to modify surfaces properties, with potential for superior stability versus grafted polymer chains . LBL coatings are comprised of alternating layers held together by secondary forces.…”

Section: Surface Modificationsmentioning

confidence: 99%

Biomedical Silicones: Leveraging Additive Strategies to Propel Modern Utility

Marmo

Grunlan

2023

ACS Macro Lett.

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Silicones have a long history of use in biomedical devices, with unique properties stemming from the siloxane (Si–O–Si) backbone that feature a high degree of flexibility and chemical stability. However, surface, rheological, mechanical, and electrical properties of silicones can limit their utility. Successful modification of silicones to address these limitations could lead to superior and new biomedical devices. Toward improving such properties, recent additive strategies have been leveraged to modify biomedical silicones and are highlighted herein.

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“…Nabavi et al (2015) developed a three-phase axisymmetric numerical model and conducted numerical simulations in ANSYS Fluent fluid analysis software to investigate the effects of physical properties (such as the flow rate, fluid interfacial tension, viscosity, and density of each phase) and geometric parameters (such as distance between the fluid inlet and outlet) on the forming droplet size, pattern, and production rate. Stauffer et al (2019) modified the wetting properties of the microchip to generate microdroplets with controlled size and shell thickness. Lian et al (2019) investigated the effect of microfluidic interfacial tension on the stepwise emulsification of microdroplets by numerical simulations using ANSYS Fluent.…”

Section: Introductionmentioning

confidence: 99%

Research on the Effect of Geometric Parameters of a Six-Way Junction Microchannel on the Formation of a Double Emulsion Droplet

2023

JAFM

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As a typical microdroplet, double emulsion droplet, has received much attention and been widely used in recent years. For a simplified double-cross-shaped microchannel, the process of preparing double emulsion droplets is numerically simulated in this paper. The mechanism of droplet forming was analyzed, and the effects of the angles of the inner-, middle-, and outer-phase channels of the microchip, length of the focusing hole, and expansion angle on the process and quality of the double emulsion droplet formation were investigated. The variation in angles between each inlet channel affects the droplet area; the change in expansion angle affects the flow pattern of droplets; the change in each geometric parameter affects the monodispersity of droplets. The droplet area is fitted to the microchannel geometric parameters and the functional expressions that represent their relationship are derived. The work in this paper provides a reference for the practical production and research of double emulsion droplets.

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Polyelectrolytes layer-by-layer surface modification of PDMS microchips for the production of simple O/W and double W/O/W emulsions: From global to localized treatment

Cited by 11 publications

References 45 publications

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

Biomedical Silicones: Leveraging Additive Strategies to Propel Modern Utility

Research on the Effect of Geometric Parameters of a Six-Way Junction Microchannel on the Formation of a Double Emulsion Droplet

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