Biomedical Silicones: Leveraging Additive Strategies to Propel Modern Utility

Marmo, Alec C.; Grunlan, Melissa A.

doi:10.1021/acsmacrolett.2c00701

Cited by 6 publications

(7 citation statements)

References 168 publications

(255 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AM of silicone multilateral structures has been observed in medical applications where the unique properties of AM combine with the flexibility and chemical inert properties of silicone 38,39 combine to make anatomical analogous structures for heart valves, 40 hard and soft tissue models, 41,42 and prosthetics. 43 These structures are important for improving the work in the medical field but are not designed as composites, rather they are designed as heterogeneous multi-material assemblies with large boundaries/infaces.…”

Section: Highlightsmentioning

confidence: 99%

Material extrusion additive manufacturing of dual material composite thermoset silicone components

Peeke,

Liu,

Periyasamy

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

Additive manufacturing (AM) is a disruptive manufacturing process that gives designers freedom to create highly complex shapes through free‐form fabrication. The majority of polymers used in extrusion AM are thermoplastics because they are easy to process in affordable machines. While there are a number of moderate modulus thermoplastics in regular use in AM, thermoplastics are known to weaken with increases in temperature or exposure to solvents and many commodity thermoplastics used in AM are brittle. On the other hand, there are few elastomers, and even fewer elastomer reinforcement schemes, that are accessible using standard AM technologies. In this work, we report a novel dual extrusion process that integrates elastomeric silicone with reinforcing thermoplastic. By developing and demonstrating a dual extrusion 3D printer that can process common thermoplastics with commercially available thermosetting silicones, new types of composite elastomers are reported with good mechanical performance. The 0°/20°/−20° grid pattern thermoplastic reinforced samples achieved 2.5 MPa tensile strength in low extension region (0.5 strain), which improves the initial stiffness of the composite component. Desired mechanical responses of composite structures can be realized by tuning the reinforcement volume ratio and infill percentages, and applying various types of reinforcement mesh patterns and thermoplastics.Highlights A dual extrusion process integrates fus filament fabrication and direct ink writing technologies. Thermoplastic reinforced silicone composite with stiff/soft properties. Tunable volume ratio, infill percentage, mesh pattern, and material option.

show abstract

Section: Highlightsmentioning

confidence: 99%

Material extrusion additive manufacturing of dual material composite thermoset silicone components

Peeke,

Liu,

Periyasamy

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

“…Moreover, the organofunctional groups on the surface of the material are usually directly attached to the silicon atoms, reducing the number of modifiable hydroxyl sites present on the surface, which will affect the water dispersibility of the material and the functionalization of the high concentration of organofunctional groups on the surface. [44,45] If the aforementioned defects can be solved, PMOs-based AIE materials will be a great candidate matrix to combine with AIEgens.…”

Section: Codoping Strategymentioning

confidence: 99%

Inorganic‐Based Aggregation‐Induced Luminescent Materials: Recent Advances and Perspectives

Zhang,

Huang,

Miao

et al. 2023

Small Structures

View full text Add to dashboard Cite

Luminogens with aggregation‐induced emission properties (AIEgens), as a novel and attractive fluorescent molecule, have been used in various fields, such as detection, imaging, and disease treatment, which can overcome the traditional aggregation‐caused quenching of organic fluorescent molecules. Nevertheless, AIEgens still have the problems of water solubility and fluorescence stability in practical applications. Aiming for improving the AIEgens’ performance and promoting the development of diverse applications of AIEgens, it is an available strategy to bind AIEgens to those inorganic materials with abundant variety, easy synthesis, and a unique rigid pore structure. The constructed inorganic‐based AIE materials not only inherit the unique luminescence characteristics of AIEgens, but also retain the biocompatibility and degradability of inorganic materials, endowing AIEgens with more attractive versatility. Herein, the up‐to‐date researches of several representative inorganic‐based AIE materials are introduced, with emphasis on their structure design, synthesis strategy, regulation of fluorescence properties of AIE, and their application in the biological field. Finally, the current situation, challenges, and future development potential of inorganic‐based AIE materials are discussed and prospected.

show abstract

“…11 a low glass-transition temperature (T g ), excellent flexibility, higher thermal and oxidative stabilities, high oxygen permeability, good biocompatibility, and very low toxicity; therefore, it is considered one of the most significant biomaterials with a high potential for a wide range of applications, including biomedical devices and wound dressing. 12,13 Furthermore, the properties of polymeric materials can be improved by making their composites. Several reinforcements and active fillers are used to develop nanocomposites of d e s i r e d p r o p e r t i e s .…”

Section: Introductionmentioning

confidence: 99%

“…However, the properties of PU can be further modified by making its block copolymers with other biocompatible polymers, i.e., polysiloxanes . Poly(dimethylsiloxane) (PDMS) possesses a wide range of desirable properties, i.e., a low glass-transition temperature ( T g ), excellent flexibility, higher thermal and oxidative stabilities, high oxygen permeability, good biocompatibility, and very low toxicity; therefore, it is considered one of the most significant biomaterials with a high potential for a wide range of applications, including biomedical devices and wound dressing. , …”

Section: Introductionmentioning

confidence: 99%

Recycled Polyurethane (rPU)-Block-Hydroxybutyl-Terminated Poly(dimethylsiloxane) (hbPDMS) (rPU-b-hbPDMS) Copolymer Nanocomposites for Osteoblast Cell Regeneration

Singh,

Kumari,

Kundu

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

The prospect of developing a polymer with mechanical properties close to the bone tissues and having good biodegradation and biocompatibility makes polyurethane (PU) a promising material for bone tissue regeneration. Here, nanocomposites were developed using postconsumer discarded polyethylene terephthalate (PET) with selectively functionalized nanofillers to prepare porous scaffolds for bone tissue regeneration. This approach motivates the sustainable recycling and circular economy aspects associated with postconsumer discarded PET waste. PET was glycolyzed with ethylene glycol through transesterification using zinc acetate as a catalyst to produce bis(2-hydroxyethyl) terephthalate (BHET). Then, BHET was reacted with 1,6-hexamethylene diisocyanate (HMDI) to produce an NCOterminated prepolymer of PU, which was then copolymerized with hydroxybutyl-terminated poly(dimethylsiloxane) (hbPDMS) using diethylenetriamine as a chain extender to impart adequate flexibility to the porous scaffolds. Studies on the U2OS osteoblast cell line showed adequate in vitro proliferations as 94 and 98% in 6 and 14 d, respectively. Hemolytic analysis shows that nanocomposites consisting of a lower loading of nanocrystals (≤2 wt %) are good for short-run bone tissue regeneration (up to 60 days), whereas a higher loading (5 wt %) is better for long-run bone tissue regeneration (60−90 days). Nanocomposites exhibit excellent mechanical, morphological, and biological properties and, thus, are potential candidates for proliferation of U2OS cells.

show abstract

Biomedical Silicones: Leveraging Additive Strategies to Propel Modern Utility

Cited by 6 publications

References 168 publications

Material extrusion additive manufacturing of dual material composite thermoset silicone components

Material extrusion additive manufacturing of dual material composite thermoset silicone components

Inorganic‐Based Aggregation‐Induced Luminescent Materials: Recent Advances and Perspectives

Recycled Polyurethane (rPU)-Block-Hydroxybutyl-Terminated Poly(dimethylsiloxane) (hbPDMS) (rPU-b-hbPDMS) Copolymer Nanocomposites for Osteoblast Cell Regeneration

Contact Info

Product

Resources

About