Surface modification of polyacrylonitrile fiber for immobilization of antibodies and detection of analyte

Jain, Swati; Chattopadhyay, S.; Jackeray, Richa; Singh, Harpal

doi:10.1016/j.aca.2009.08.030

Cited by 38 publications

(28 citation statements)

References 37 publications

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“…Reduced PAN-nfs as supports Jain et al [1] reduced PAN-nfs with LiAlH 4 (Fig. 2a) to amino groups and activated it with glutaraldehyde for the covalent linking of Goat anti-Rabbit enzyme conjugate.…”

Section: Hydrazine-modified Pan-nfs As Supportsmentioning

confidence: 68%

“…The surface morphology as observed on SEM images by Jain et al [1] noted that no major morphological changes happened on glutaraldehyde-activated PAN-nfs. After immobilization of antibodies, it was observed at higher magnification that the antibodies deposited of the surface of the fibres [1].…”

Section: Hydrazine-modified Pan-nfs As Supportsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

“…Covalent binding of these materials is always emphasized for the sake of reusability and to eliminate concerns regarding adverse effects that may be associated with leaching of any of these materials [1]. Tethering of enzymes or antibacterial agents to solid supports via functional groups can give characteristics, such as specific absorption, greater stability, and enhanced biological activities [1,2]. Surface-modified PAN-nfs have extensively been used as supports for different enzymes for various industrial and biomedical applications, such as biocatalysts, bioreactors, and protein filtration [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Surface-modified polyacrylonitrile nanofibres as supports

et al. 2016

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Polyacrylonitrile nanofibers ( PAN-nfs) are one of t he most studied nanofibres because of their excellent characteristics, such as good mechanical strength, chemical resistance, and good thermal stability. Due to the easy dissolution in polar organic solvents, PAN-nfs are mostly produced via electrospinning technique. The electrospun PAN-nfs surfaces are relatively in-active and hydrophobic, and, therefore, hinder some potential applications; however, chemical surface modification reactions, such as amination, reduction, hydrolysis, and amidoximation, have been carried out on them. These reactions bring about functional groups, such as amine, hydroxyl, carboxylic, imine etc, to the surface PAN-nfs and invariably make their surfaces active and hydrophilic. The surface-modified PAN-nfs have been used as supports for organic compounds, enzymes, and antibodies in biological studies. They have also been used for immobilization of various organic ligands for adsorption of metal ions in water. Furthermore, because of their ability to complex metal ions, several surface-modified PAN-nfs have also been used as supports for transition metal catalysts in Fenton's chemistry.

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Section: Hydrazine-modified Pan-nfs As Supportsmentioning

confidence: 68%

Section: Hydrazine-modified Pan-nfs As Supportsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surface-modified polyacrylonitrile nanofibres as supports

et al. 2016

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“…24 h reduced fibers gave the most stable and reproducible results on immobilization of antibodies. Modified PAN fibers had a strong potential to be used as matrix for the detection of pathogenic bacteria and medical diagnostics (Jain et al, 2009). Another approach carried out by Cui and Yoon to modify the surface of PET film by treatment with ethoxylated hexylaminoanthraquinones synthesized by the reaction of 1-aminoanthraquinone with poly(ethylene glycol)s via hexamethylene spacer.…”

Section: Micro Surface Modification Of Textiles By Aqueous Solutionsmentioning

confidence: 99%