Surface modification of monodisperse‐crosslinked polymeric microspheres using a redox initiation system

Jung, Mi-Ok; Ryu, Jihye; Park, Jin Gyu; Jun, Jung-Bae; Suh, Kyung‐Do

doi:10.1002/app.23546

Cited by 7 publications

(8 citation statements)

References 41 publications

(32 reference statements)

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“…In recent years polymer particles with well defined particle size and various reactive functional groups on the surface are attracting much interest because of their applications in a broad range of fields, e.g. as binders in paints, adhesives, paper coating, textile and as a solid support in the biochemical and biological field as well as in catalysis and calibration standards [1][2][3][4][5]. The functional groups include hydroxyl [6][7][8], aldehyde [9][10][11], carboxyl [12][13][14][15][16], amino [17][18][19], epoxy [20][21][22], cyano [23], sulfhydryl [24] and chloromethyl groups [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Micron-Sized Di-Functional Magnetic Composite Polymer Particles

Ahmad¹,

Tofaz²,

Oli³

et al. 2010

MSA

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In this investigation micron-sized monodisperse magnetic composite polymer particles with amino and amide functional groups were prepared considering their applications in biotechnology. First, polystyrene/poly (acrylic acid-acrylam- ide-N-N-methylene-bis-acrylamide) [PS/P(AA-AAm-MBAAm)] composite polymer particles were prepared by seeded copolymerization. The carboxyl groups present on or near the particles surface were modified by amine-nucleophile, ethylene diamine (EDA), through pre-activation with dicyclohexyl carbodiimide as coupling agent. The aminated particles were then magnetically modified and named as aminated-Fe3O4 composite particles. Formation of such magnetic composite particles was confirmed by scanning electron micrographs, FTIR-spectra and magnetic susceptibility measurement. The produced composite particles were paramagnetic. To see the relative hydrophilic character of the particles surface the adsorption behavior of trypsin (TR) as biomolecule was studied on PS particles and aminated-Fe3O4 composite particles. The magnitude of adsorbed TR on PS particles was higher than that on aminated-Fe3O4 composite particles

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Section: Introductionmentioning

confidence: 99%

Preparation of Micron-Sized Di-Functional Magnetic Composite Polymer Particles

Ahmad¹,

Tofaz²,

Oli³

et al. 2010

MSA

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show abstract

“…The structural feature allows OADs to form a supramolecular ordered structure through intermolecular translation-related hydrogen bonding. 23,24 The π−π interaction and the intermolecular hydrogen bonds might have a synergistic effect on the formation of stable aggregations. 37 38 Some practical measurements such as FT-IR and 1 H NMR spectra have also been provided for understanding the intermolecular interaction and packing order (vide infra).…”

Section: Resultsmentioning

confidence: 99%

“…The resulting solution was stirred for 5 h at room temperature and then poured into ice-water to remove pyridine salt. The white solid obtained by filtration was washed three times by distilled water and dried under vacuum for 24 2.4. Self-Assembling Experiment.…”

Section: Methodsmentioning

confidence: 99%

Fabrication of Microspheres via Solvent Volatization Induced Aggregation of Self-Assembled Nanomicellar Structures and Their Use as a pH-Dependent Drug Release System

et al. 2012

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A series of oleamide derivatives, (C(18)H(34)NO)(2)(CH(2))(n) [n = 2 (1a), 3 (1b), 4 (1c), or 6 (1d); C(18)H(34)NO = oleic amide fragment] and (C(18)H(34)NO)(CH(2))(6)NH(2) (2), have been synthesized and their self-assembly is investigated in ethanol/water media. Self-assembly of 1a and 1b in ethanol/water (1/0.1 v/v) solution (5 mg mL(-1)) yields microspheres (MSs) with the average diameter ∼10 μm via a gradual temperature reduction and solvent volatilization process. Under the same self-assembly conditions, microrods (average diameter ∼6 μm and several tens of micrometers in length), micronecklace-like, and shape-irregular microparticles are formed from the self-assembly of 1c, 1d, and 2, respectively. The kinetics of evolution for their self-assemblies by dynamic light scattering technique and in situ observation by optical microscopy reveals that the microstructures formation is from a well-behaved aggregation of nanoscale micelles induced by solvent volatilization. The FT-IR and temperature-dependent (1)H-NMR spectra demonstrate the hydrogen bonding force and π-π stacking, which drove the self-assembly of all oleamide derivatives in ethanol/water. Among the fabricated microstructures, the MSs from 1a exhibit the best dispersity, which thus have been used as a scaffold for the in vitro release of doxorubicin. The results demonstrate a pH-sensitive release process, enhanced release specifically at low pH 5.2.

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“…The methods include emulsion polymerization, suspension polymerization, dispersion polymerization and seeded emulsion polymerization. Functional polymer microspheres have also been obtained by surface modification of preformed microspheres (8). The above methods have been reported numerous times and several papers provided comprehensive reviews on them (1,2,9,10).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Hydrophilic Polystyrene Microspheres with Casein Molecules on the Surface

Wei

2008

Journal of Macromolecular Science, Part A

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In this study, suspension polymerization is described to prepare hydrophilic polystyrene microspheres with casein macromolecules on the surface. In the suspension polymerization, casein w as used as an emulsifier and stabilizer instead of synthetic surfactants. The microspheres had spherical shape and the size distribution was narrow, the average size was about 3.5 mm. The microspheres were characterized with a Fourier transform infrared spectroscopy, revealing the existence of hydroxyl, carboxyl and amino groups. XPS analysis was carried out to study the surface composition, it revealed that the nitrogen concentration was 5.04% on the surface of the particles and it remained almost unchanged after the particles were washed by 2% SDS. The microspheres were confirmed to be hydrophilic due to the casein molecules on the surface.

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Surface modification of monodisperse‐crosslinked polymeric microspheres using a redox initiation system

Cited by 7 publications

References 41 publications

Preparation of Micron-Sized Di-Functional Magnetic Composite Polymer Particles

Preparation of Micron-Sized Di-Functional Magnetic Composite Polymer Particles

Fabrication of Microspheres via Solvent Volatization Induced Aggregation of Self-Assembled Nanomicellar Structures and Their Use as a pH-Dependent Drug Release System

Preparation of Hydrophilic Polystyrene Microspheres with Casein Molecules on the Surface

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