Surface modification of Mitoxantrone-loaded PLGA nanospheres with chitosan

Chitosan–polycaprolactone copolymer microspheres for transforming growth factor-β1 delivery

“…Release of bioactive molecules or drugs from polymer microspheres usually depends upon many factors involved in structures, morphologies and physico-chemical properties of the microspheres as well as loaded molecules or drugs [31][32][33]. Since the composition of CPCs and the amount of crosslinker were found to be two key parameters for modulating the morphologies and properties of TGF-␤1-loaded microspheres, the effect of the composition of CPCs and the amount of crosslinker on in vitro release behavior of microspheres was selectively investigated.…”

Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: In vitro and in vivo investigations

“…Nanoparticles of several synthetic polymers, e.g. polyurethanes , poly(lactic-co-glycolic acid) (Chen et al, 2009) and natural polymers like chitosan (Vivek et al, 2013) have demonstrated promising results for efficient drug delivery to the cancerous cells. Despite the positive results, these polymers have their own disadvantages like the higher cost and slow degradability of poly(lactic-co-glycolic acid) limits its use.…”

Preparation of biocompatible heat-labile enterotoxin subunit B-bovine serum albumin nanoparticles for improving tumor-targeted drug delivery via heat-labile enterotoxin subunit B mediation

“…[2][3][4] Although chemotherapeutic drugs are effective at killing tumor cells, there are some drawbacks, including nonselective distribution, drug toxicity, and unexpected side effects to normal tissues, which limit their clinical usage. 5,6 Generally, it is difficult to achieve satisfactory therapeutic effects in cancer treatment with conventional treatment methods, thus it is urgent that a more active and effective way to fight against cancer is found.…”