Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: In vitro and in vivo investigations

Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers

“…39,49 This approach allows researchers to measure the complex's log P empirically and fully characterize it using techniques such as differential scanning calorimetry (DSC), X-ray diffraction (XRD), NMR, FTIR, etc. 79 Isolated complexes are oen loaded into an oil phase or organic solvent (e.g. DCM 80,81 or acetone 82 ) and treated as a lipophilic molecule.…”

Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability

“…Currently, advances in nanotechnology have made it possible to improve the solubility, bioavailability, and absorbency of medicinal herbs as well as couple these advances with using a reduced dose and a sustained steady-state of therapeutic level of drugs over an extended period compared with the traditional methods [8][9][10][11] . Among the numerous nano-suspensions, the colloidal delivery system of polymeric nanoparticles has attracted much attention as a result of its unique properties, such as high biocompatibility, non-toxic nature, long-term stability, good physiological features, and acceptable control release [12,13] . The polymeric nanoparticles with smaller particle sizes (approximately 200 nm) could also increase drug accumulation in tumor cells via enhanced permeability and retention (EPR) effects [14][15][16] .…”

CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel

“…HA coated SLM loaded PLGA nanoparticles (SLM-HA-NPs) were prepared by emulsion solvent diffusion technique, according to an earlier reported method with some modifications [32,33]. Briefly, 22.5 mg polymer was dissolved in 2.25 ml ethyl acetate and to this 2.5 mg of SLM was added in 0.25 ml of ethanol.…”