Surface modification of magnesium by functional polymer coatings for neural applications

Augello, Catherine; Liu, H.

doi:10.1016/b978-1-78242-078-1.00012-8

Cited by 14 publications

(14 citation statements)

References 38 publications

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“…The inherent surface properties of polymers, such as poor wettability and low surface area, lead to substandard bioactivity and make it challenging to use these in implants. Conversely, polymer-coated implants can serve as biomimetic surfaces in the body [ 2 ]. Polymers can also be used to coat the surface of nanoparticles to improve their performance in the delivery of biomolecules and drugs.…”

Section: Polymer Coatings and Filmsmentioning

confidence: 99%

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Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Section: Polymer Coatings and Filmsmentioning

confidence: 99%

“…This technique permits the tailoring of various characteristics, such as elasticity, wettability, bioactivity, and adhesiveness [ 14 ]. Biodegradable polymer coatings can be applied as corrosion resistance coatings in implants to prevent corrosion post implantation [ 2 ].…”

Section: Biopolymer Coatings On Metal Implantsmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…Electrophoretic deposition (EPD) as a versatile and cost‐effective material processing technique, appears of particular interest in surface modifications of materials for biomedical applications, because it allows the deposition of homogeneous and dense ceramic and organic/inorganic coatings on complex geometries and shapes. [ 22 ] It can well control the thickness and microstructure of the deposited coating by adjusting the applied voltage and treatment time. [ 23 , 24 ] In our recent research, we have deployed EPD to fabricate a bioactive hydroxyapatite (HA) coating on the surface of the conductive PEEK/graphene (P/G) composite, showing that EPD is a powerful technique to deposit an antibacterial and bioactive HA coating with tailored composition, thickness and structure on the substrate in short time.…”

Section: Introductionmentioning

confidence: 99%

Endowing Conductive Polyetheretherketone/Graphene Nanocomposite with Bioactive and Antibacterial Coating through Electrophoresis

Zhu

et al. 2021

Macro Materials & Eng

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Polyetheretherketone (PEEK) and its composites have been widely used in orthopedics and trauma. In this work, a bioactive calcium carbonate (CaCO3) coating incorporated with silver nanoparticles (AgNPs) is coated on the conductive PEEK/graphene nanocomposite (P/G) through electrophoretic deposition (EPD) by pumping CO2 to provide tiny amount of CO32− groups for reacting with Ca2+, the obtained sample is named as Ca/Ag@P/G. The morphology, structure, and surface chemistry of the fabricated Ca/Ag@P/G are characterized by means of SEM‐EDS, XRD, XPS, as well as water contact angle testing, and the results confirm that the mixture coating composed of CaCO3 and AgNPs is less crystalline and more hydrophilic than the single CaCO3 coating on P/G (namely Ca@P/G). The Ca/Ag@P/G exhibits desirable antibacterial ability against both S. aureus and E. coli with the bactericidal rate of 99.9% and 96.7%, respectively, meanwhile it displays excellent biocompatibility with improved cell spread and proliferation. Moreover, the incorporation of graphene nanosheets endows Ca/Ag@P/G with great photothermal conversion effect, which is favorable to enhancing osteogenesis capability and synergistically killing/prohibiting bacteria/tumor cells. The multifunctional Ca/Ag@P/G composite has a promising prospect in the potential applications for infectious/tumorous bone repair applications.

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“…Chitosan, a naturally occurring biopolymer, is extracted by the chitin's diacylation and comprises the insect exoskeleton [12,13]. It is biocompatible, biodegradable, non-toxic, and antibacterial, thus making it a useful component of many biomedical applications [14]. Halloysite is an aluminosilicate nanotube comprising rolled-up sheets of silica and alumina, resulting in an oppositely charged outer surface and an inner core [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Electrophoretic deposition (EPD) is a two-step coating method involving the movement of charged materials under an applied electrical field and the subsequent accumulation and deposition of the charged material on the oppositely charged electrodes [14]. Previous studies have applied EPD to fabricate surface coatings of titanium nanoparticles under different alcohol solutions [15], zinc-halloysite substituted hydroxyapatite [16] and a chitosan (CS)-HNT bioactive glass composite [6].…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition of Gentamicin-Loaded ZnHNTs-Chitosan on Titanium

2020

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There is a need for titanium (Ti), an antimicrobial implant coating that provides sustained protection against bacterial infection. Chitosan (CS) coatings, combined with halloysite nanotubes (HNTs), are an attractive solution due to the inherent biocompatibility of halloysite, its ability to provide sustained drug release, and the antimicrobial properties of CS. In this study, the electrodeposition (EPD) method was used to coat titanium foil with CS blended with zinc-coated HNTs (ZnHNTs) and pre-loaded with the antibiotic gentamicin. The CS-ZnHNTs-gentamycin sulfate (GS) coatings were characterized using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray powder diffraction (XRD), X-ray fluorescence (XRF), Fourier-transform infrared spectroscopy (FTIR), and UV-visible spectroscopy. The coatings were further examined for their ability to sustain GS release, resist bacterial colonization and growth, and prevent biofilm formation. The CS-ZnHNTs-GS coatings were cytocompatible, exhibited significant antimicrobial properties, and supported pre-osteoblast cell proliferation. Hydroxyapatite also formed on the coatings after immersion in simulated body fluid. While the focus in this study was on zinc-coated HNTs doped into CS, our design offers tunability, as different metals can be coated onto the HNT surface and different drugs or growth factors loaded into the HNT lumen. Our results, and the potential for customization, suggest that these coatings have potential in the construction of an array of infection-resistant implant coatings.

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Surface modification of magnesium by functional polymer coatings for neural applications

Cited by 14 publications

References 38 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

Endowing Conductive Polyetheretherketone/Graphene Nanocomposite with Bioactive and Antibacterial Coating through Electrophoresis

Electrophoretic Deposition of Gentamicin-Loaded ZnHNTs-Chitosan on Titanium

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