Surface Modification of Bare-Metal Stents for Preventing Restenosis  (Part 1)

Лотков, А. И.; Матвеева, В. Г.; Антонова, Л. В.; Кашин, О. А.; Kudriashov, Andrii

doi:10.17802/2306-1278-2017-1-122-130

Cited by 4 publications

(2 citation statements)

References 23 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stents [5,6] and metal plates [7,8] are the most commonly used metal implants. To investigate biocompatibility of promising metal alloys (for example, titanium nickelide), it is required to implant medical device prototypes made of the above alloys into laboratory animals, which is followed by assessment of connective tissue capsule formation, infiltration by immunocompetent cells and neovascularization [9,10].…”

Section: Introductionmentioning

confidence: 99%

A Novel Technique for Preparation, Staining, and Visualization of Tissue with Metal Implants and Extraskeletal Calcification Areas

Mukhamadiyarov¹,

Богданов²,

Мишинов³

et al. 2020

Sovrem Tehnol Med

View full text Add to dashboard Cite

The aim of the study was to evaluate the efficacy of a novel technique for preparation, staining, and visualization of tissues containing extra-skeletal mineralization areas, all-metal implants or their prototypes for their subsequent examination using scanning electron microscopy in the backscattered electron mode. Materials and Methods. After fixation in 10% formalin (24 h), the biomaterial (a titanium nickelide plate with the surrounding tissues after subcutaneous implantation, patented titanium alloy plates with the surrounding tissues after cranioplasty, primary and secondary calcified atherosclerotic plaques) were fixed with 1% osmium tetroxide (12 h) and then stained with 2% aqueous solution of osmium tetroxide (48 h). The samples were further stained with 2% alcoholic uranyl acetate (5 h), dehydrated with isopropanol (5 h) and acetone (1 h), impregnated with a mixture of acetone and epoxy resin Epon (1:1, 6 h) and then embedded into a fresh portion of epoxy resin (24 h), which was followed by polymerization at 60°C. After grinding and polishing, epoxy blocks were counterstained with lead citrate (7 min) and sputter-coated with carbon, then the samples were visualized by scanning electron microscopy in the backscattered electron mode. The elemental composition was studied using X-ray microanalysis. Results. The developed technique allows obtaining high-quality images at five thousand-fold magnifications, provides the possibility to identify the shape and structure of intact metal and mineral inclusions, and to type the surrounding cells, distinguishing mesenchymal and immunocompetent cells by shape and cytoplasmic content. Apart from connective tissue capsule thickness and leukocyte infiltration, this technique makes it possible to estimate the number and area of newly formed small-caliber vessels representing a surrogate marker of inflammation. Conclusion. The proposed technique provides the possibility to investigate adequately the structure of samples when their sectioning is impossible or significantly complicated, with image quality remarkably higher than that obtained by light microscopy.

show abstract

Section: Introductionmentioning

confidence: 99%

A Novel Technique for Preparation, Staining, and Visualization of Tissue with Metal Implants and Extraskeletal Calcification Areas

Mukhamadiyarov¹,

Богданов²,

Мишинов³

et al. 2020

Sovrem Tehnol Med

View full text Add to dashboard Cite

show abstract

“…Audio-visual stimulation (AVS) has recently attracted increased attention due to a number of advantages: mobility, ease of implementation, fast and complex effects, capability to improve human health and functional state [ 1 – 6 ]. Recent studies have demonstrated the possibility of using AVS to improve sports training regimes [ 7 – 9 ] and to confirm the differential diagnosis in chronic disorder of consciousness [ 10 ]. In attempt to identify AVS mechanisms, we evaluated the efficacy of using a single AVS session to correct the functional state of the body [ 11 ], studied the effects of various AVS types [ 12 ], including music-light effects formed on the basis of human bioelectrical processes [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Light and Music Stimulation Controlled by a Person’s Own Brain and Heart Biopotentials or Those of Another Person

et al. 2020

View full text Add to dashboard Cite

The aim of the study was to carry out comparative analysis of effects observed in subjects exposed to light and music stimulation controlled by their own brain and heart biopotentials (closed-loop method) or biopotentials of another person. Materials and Methods. Volunteers under stress participated in two experiments in pairs. In the first experiment, light and music stimulation effects formed in each subject in a pair on the basis of their own brain and heart biopotentials, while in the second experiment, they formed on the basis of biopotentials of the other subject. Results. Both types of exposure caused reducing the tension of the regulatory systems in the body, reducing stress levels and improving the emotional state due to the mechanisms of multisensory integration and neuroplasticity. A significant increase in the power of the main EEG rhythms, accompanied by significant positive changes in psychological testing results and positive emotional responses to stimulation was observed only during light and music stimulation controlled by the subjects' own brain and heart biopotentials. These data are attributable to the integration of perception and processing of interoceptive signals significant for humans into the resonance mechanisms of the central nervous system, providing normalization of functional state due to stimulation. Conclusion. The data obtained can be used for developing the effective methods of personalized light and music stimulation aimed at timely elimination of functional disorders and returning the human body to homeostasis.

show abstract

Backscattered Scanning Electron Microscopy Approach for Assessment of Microvessels under Conditions of Normal Microanatomy and Pathological Neovascularization

Mukhamadiyarov

Kutikhin

2020

Bull Exp Biol Med

View full text Add to dashboard Cite

Surface Modification of Bare-Metal Stents for Preventing Restenosis (Part 1)

Cited by 4 publications

References 23 publications

A Novel Technique for Preparation, Staining, and Visualization of Tissue with Metal Implants and Extraskeletal Calcification Areas

A Novel Technique for Preparation, Staining, and Visualization of Tissue with Metal Implants and Extraskeletal Calcification Areas

Mechanisms of Light and Music Stimulation Controlled by a Person’s Own Brain and Heart Biopotentials or Those of Another Person

Backscattered Scanning Electron Microscopy Approach for Assessment of Microvessels under Conditions of Normal Microanatomy and Pathological Neovascularization

Contact Info

Product

Resources

About