Endogenous opioid peptide (EOP) system plays an important role in the interaction of human organism with different stress factors, providing stress-limiting and stress-protective functions. Different kinds of electrostimulation seem to produce anti-stress and pain relief effects due to EOP system activation. The presented paper reviews recent literature concerning EOP system activation under electrostimulation and its reflections in the EEG characteristics. The results and opportunities of high resolution EEG structure analysis utilization for EOP level control, as well as for stress-induced state assessment and correction via resonance activation of brain EEG oscillators by means of frequency-tuned external stimulation are presented.
Brain-computer interface and neurofeedback technologies are unique techniques to modulate brain activity based on an operant conditioning. From the time these technologies appeared in the 60-ies of the XX c., they have become non-drug tools for numerous psychiatric and neurologic disorders. However, up to now their efficiency is a matter of debate. Our review considers the background, characteristic features and current state of the technologies. The emphasis was made on the analysis of capabilities and prospects of the technologies in clinical medicine to mobilize the plasticity mechanisms of brain neural network. The review presents the findings of our own experiments showing the future of brain-computer interface and neurofeedback technologies to depend on multi-type cooperation of neurologists, neurobiologists, engineers and mathematicians. Effective consolidation of several fields of science will enable to develop novel therapeutic regimens to restore and improve neural, cognitive and behavioral functions.
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