Surface modification and characterization of photon-upconverting nanoparticles for bioanalytical applications

Sedlmeier, Andreas; Gorris, Hans H.

doi:10.1039/c4cs00186a

Cited by 395 publications

(351 citation statements)

References 198 publications

(711 reference statements)

Supporting

Mentioning

348

Contrasting

Unclassified

Order By: Relevance

“…Therefore, surface modification is usually demanded to transfer the hydrophobic NPs into hydrophilic ones with appropriate functional groups (e.g., amino and carboxy) for subsequent bioconjugation ( Figures 3 a and 3b) 17. For this purpose, a number of surface modification strategies have been established, such as ligand exchange, ligand oxidation, ligand‐free synthesis, ligand attraction, electrostatic layer‐by‐layer assembly, and surface silanization 18…”

Section: General Protocols For the Fabrication Of Inorganic Lanthanidmentioning

confidence: 99%

Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano‐Bioprobes

Zheng

Zhou

et al. 2016

Advanced Science

View full text Add to dashboard Cite

Ultrasensitive and accurate detection of tumor markers is of vital importance for the screening or diagnosis of cancers at their early stages and for monitoring cancer relapse after surgical resection. Inorganic lanthanide (Ln3+) nanoparticles (NPs), owing to their superior physicochemical characteristics, are regarded as a new generation of luminescent nano‐bioprobes in the field of cancer diagnosis and therapy. In this progress report, a focus is set on our recent efforts on the development of inorganic Ln3+‐NPs as efficient luminescent nano‐bioprobes for the ultrasensitive in vitro biodetection of tumor markers, with an emphasis on the dissolution‐enhanced luminescent bioassay (DELBA), an emerging technique recently developed toward practical medical applications.

show abstract

Section: General Protocols For the Fabrication Of Inorganic Lanthanidmentioning

confidence: 99%

Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano‐Bioprobes

Zheng

Zhou

et al. 2016

Advanced Science

View full text Add to dashboard Cite

show abstract

“…For a deeper and more detailed description of these matters, some excellent reviews can be found in the recent literature [19,[29][30][31][32][33][34][35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

et al. 2017

View full text Add to dashboard Cite

Abstract:Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose of this review is to provide a general and comprehensive overview of the current state of the art, with special focus on the commonly employed synthesis methods and functionalization strategies of rare earth based nanoparticles and on their different bioimaging and biosensing applications. The luminescent (including downconversion, upconversion and permanent luminescence) and magnetic properties of rare earth based nanoparticles, as well as their ability to absorb X-rays, will also be explained and connected with their luminescent, magnetic resonance and X-ray computed tomography bioimaging applications, respectively. This review is not only restricted to nanoparticles, and recent advances reported for in other nanostructures containing rare earths, such as metal organic frameworks and lanthanide complexes conjugated with biological structures, will also be commented on.

show abstract

“…37,38 Manipulation of IR radiation using UCNPs has been found to be of much interest because the UV-VIS output can be used to promote several chemical processes or to develop a number of applications in the fields of lighting and displays, energy, photocatalysis, sensing, bioanalytics and theranostics. [39][40][41][42][43][44][45] Up to our knowledge, only two reports concerning the inclusion of UCNPs in self-assembled organogels are available in the literature.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Light-Harvesting Soft Hybrid Materials: Assisted Energy Transfer upon Thermally Reversible Gelation

et al. 2017

View full text Add to dashboard Cite

Multimodal light-harvesting soft systems able to absorb UV-to-NIR radiations and convert into visible emissions have drawn much attention in the last years in order to explore new areas of application in energy, photonics, photocatalysis, sensors and so forth. Here, we present a new hybrid system combining a supramolecular photonic gel of naphthalimide-derived molecules self-assembled into fibers and upconverting NaYF 4 :Yb/Tm nanoparticles (UCNPs). The hybrid system presented here manipulates light reversibly as a result of an optical communication between the UCNPs and the photoactive gel network. Upon UV irradiation, the system shows the characteristic emission at 410 nm from the photoactive organomolecule. This emission is also activated upon 980 nm excitation thanks to an efficient energy transfer from the UCNPs to the fibrillary network. Interestingly, the intensity of this emission is thermally regulated during the reversible assembly or disassembly of the organogelator molecules, in such a way that gelator emission is only observed in the aggregated state. Additionally, the adsorption of the UCNPs with the supramolecular gel fibers enhance their emissive properties, a behavior ascribed to the isolation from solvent quenchers and surface defects, as well as an increased IR light scattering promoted by the fibrillary network. The reported system constitutes a unique case of a thermally regulated, reversible, dual UV and IR light harvesting hybrid soft material.3

show abstract

Surface modification and characterization of photon-upconverting nanoparticles for bioanalytical applications

Abstract: A well-defined surface architecture is essential to generate water-dispersible UCNPs that are long-term stable and enable a wealth of bioanalytical applications.

Cited by 395 publications

References 198 publications

Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano‐Bioprobes

Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano‐Bioprobes

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

Multimodal Light-Harvesting Soft Hybrid Materials: Assisted Energy Transfer upon Thermally Reversible Gelation

Contact Info

Product

Resources

About