Surface functionalization of titanium substrates with Deoxyribonuclease I inhibit peri-implant bacterial infection

Shao, Can; Zhang, Xin; Ye, Jing; Li, Yachong; Bao, Yi-Jun; Li, Zhihui; Huang, Ying; Liu, Ying

doi:10.4012/dmj.2020-055

Cited by 2 publications

(1 citation statement)

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“…Therefore, matrix disruptive agents such as enzymes, cationic chelators, and compounds provide us with another effective treatment strategy against biofilm-associated infections. These biofilm-dispersing agents can be used to functionalize the surface of medical devices to inhibit the formation of biofilms and can also be combined with other antibiofilm agents or technologies to improve antibiofilm activity [234,235,244,245].…”

Section: Agents For Degradation Of the Extracellular Matrix Of Biofilmsmentioning

confidence: 99%

Novel Approaches to Combat Medical Device-Associated BioFilms

Sun

Zhang

et al. 2021

Coatings

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Biofilms are aggregates formed as a protective survival state by microorganisms to adapt to the environment and can be resistant to antimicrobial agents and host immune responses due to chemical or physical diffusion barriers, modified nutrient environments, suppression of the growth rate within biofilms, and the genetic adaptation of cells within biofilms. With the widespread use of medical devices, medical device-associated biofilms continue to pose a serious threat to human health, and these biofilms have become the most important source of nosocomial infections. However, traditional antimicrobial agents cannot completely eliminate medical device-associated biofilms. New strategies for the treatment of these biofilms and targeting biofilm infections are urgently required. Several novel approaches have been developed and identified as effective and promising treatments. In this review, we briefly summarize the challenges associated with the treatment of medical device-associated biofilm infections and highlight the latest promising approaches aimed at preventing or eradicating these biofilms.

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Section: Agents For Degradation Of the Extracellular Matrix Of Biofilmsmentioning

confidence: 99%