Surface functionalization of halloysite nanotubes with supermagnetic iron oxide, chitosan and 2-D calcium-phosphate nanoflakes for synergistic osteoconduction enhancement of human adipose tissue-derived mesenchymal stem cells

Lee, Yoo-Jung; Lee, Seung‐Cheol; Jee, Seung-Cheol; Sung, Jung‐Suk; Kadam, Avinash A.

doi:10.1016/j.colsurfb.2018.09.045

Cited by 37 publications

(26 citation statements)

References 37 publications

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“…In general, in BTE, scaffolds should be osteogenic and could offer differentiation cues to accelerate bone progenitor cells or stem cells into osteogenic phenotypes (Moradi, Golchin, Hajishafieeha, & Khani, ). Stem cells are pluripotent, with the ability to self‐renew, which can differentiate them into diverse lineages, such as neuronal cells, chondrocytes, adipocytes, and osteoblasts (Lee, Lee, Jee, Sung, & Kadam, ). As demonstrated by numerous researchers, bone‐marrow‐derived mesenchymal stem cells (BMSCs) have become one of the most promising treatments for the improvement of osteoblast differentiation in BTE (Duan, Chen, Haque, Hayes, & Lopez, ).…”

Section: Introductionmentioning

confidence: 99%

Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide

Chen

et al. 2019

J Biomedical Materials Res

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The scaffold-free cell sheet plays an important role in stem-cell-based regeneration.Graphene oxide (GO) endows nanoparticles (NPs) with special characteristics and therefore has attracted increasing attention in recent years. However, the existence of toxicity in GO and its derivatives limits their ability to promote osteogenic differentiation. Magnetic graphene oxide (MGO), a novel combination of Fe 3 O 4 and GO with diverse unique properties, has not been studied in bone tissue engineering. In this study, MGO was fabricated, and the previously undiscovered relationshipsincluding cellular behavior and the effects of osteogenic differentiation and related mechanisms of MGO in rat bone-marrow-derived mesenchymal stem cells (BMSCs)were investigated for the first time. Here, we found that MGO was not only biocompatible at low concentrations, but also could significantly accelerate osteogenic differentiation in BMSCs. Both the cellular behavior and bone-formation differentiation in BMSCs treated with MGO showed concentration-dependent characteristics. In addition, the regulation of osteogenic differentiation in BMSCs treated with MGO might be involved with the Wnt/β-catenin and BMP signaling pathways. Furthermore, MGO demonstrated a better ability for osteogenic differentiation in BMSCs than did GO. The current work indicated a significant use for MGO nanocomposite scaffolds in biocompatibility and bone regeneration, which could provide new insight into bone regeneration in the future. K E Y W O R D S bone marrow mesenchymal stem cells, bone tissue regeneration, cellular behavior, magnetic graphene oxide, osteogenic differentiation

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Section: Introductionmentioning

confidence: 99%

Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide

Chen

et al. 2019

J Biomedical Materials Res

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“…Recently, Lee et al. reported the fabrication of HNTs modified with superparamagnetic iron oxide, chitosan, and 2D calcium‐phosphate nanoflakes that was found to be multifunctional nanoscaffold, with exceptional osteoconduction potential for bone tissue engineering …”

Section: Modifications Of Nanotubes For the Modulation Of Tissue Engimentioning

confidence: 99%

Halloysite Nanoclay/Biopolymers Composite Materials in Tissue Engineering

Naumenko

Fakhrullin

2019

Biotechnology Journal

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Biocompatible materials for the fabrication of tissue substitutes are crucially important in the advancement of modern medicinal biotechnology. These materials, to serve their function, should be similar in physical, chemical, biological, and structural properties to native tissues which they are aimed to mimic. The porosity of artificial scaffolds is essential for normal nutrient transmission to cells, gas diffusion, and cell attachment and proliferation. Nanoscale inorganic additives and dopants are widely used to improve the functional properties of the polymer materials for tissue engineering. Among these inorganic dopants, halloysite nanotubes are arguably the most perspective candidates because of their biocompatibility and functional properties allowing to enhance significantly the mechanical and chemical stability of tissue engineering scaffolds. Here, this vibrant field of biotechnology for regenerative medicine is overviewed.

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“…PCL scaffolds coated with CS/Gelatin nanoparticles had a higher potency to be applied for BTE applications . Emerging materials such as halloysite nanotubes in nanomedical applications were modified with CS to maximize its osteogenic potential . Entrapment of CS on the surface of polymeric scaffolds has been found to have good bioactivity …”

Section: Cs As a Surface Modifier In Btementioning

confidence: 99%

Chitosan in Surface Modification for Bone Tissue Engineering Applications

Abinaya

Prasith

Ashwin

et al. 2019

Biotechnology Journal

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Traditional methods of bone defect repair include autografts, allografts, surgical reconstruction, and metal implants that have several disadvantages such as donor site morbidity, rejection, risk of disease transmission, and repetitive surgery. Biomaterial‐based bone reconstructions can, therefore, be an efficient alternative due to the inherent properties of the materials. Chitosan (CS), the deacetylated form of chitin, is a biopolymer having a wide array of applicability in regenerative tissue applications owing to its biocompatible, in vitro degradative and bioresorbable nature. Extensive studies are being carried out using CS to augment the properties of the already existing methods and to also improve the applicability of CS‐based biocomposites in bone tissue repair. In this review, the suitability of CS as a surface modifier has been discussed in detail for the already existing implants, surface modifications of CS‐based natural biocomposites for bone tissue regeneration, and the wide range of techniques that can introduce these modifications. CS, being a natural polymer, possesses advantageous properties including surface modifier that makes it a suitable candidate for bone regeneration, and further research to investigate its osteogenic potential in vivo along with the molecular and signaling mechanisms involved in bone regeneration can aid in expanding its applicability in clinical trials.

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Surface functionalization of halloysite nanotubes with supermagnetic iron oxide, chitosan and 2-D calcium-phosphate nanoflakes for synergistic osteoconduction enhancement of human adipose tissue-derived mesenchymal stem cells

Cited by 37 publications

References 37 publications

Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide

Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide

Halloysite Nanoclay/Biopolymers Composite Materials in Tissue Engineering

Chitosan in Surface Modification for Bone Tissue Engineering Applications

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