Surface-enhanced Raman spectroscopy (SERS) combined techniques for high-performance detection and characterization

Zhang, Ye; Zhao, S. Y. F.; Zheng, Jinkai; He, Lili

doi:10.1016/j.trac.2017.02.006

Cited by 103 publications

(52 citation statements)

References 127 publications

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“…To address the on‐site determination of contaminants in complex matrices, integration SERS with separation techniques on a chip has been demonstrated as a feasible strategy . At present, various separation techniques, such as column liquid chromatography, thin layer chromatography, solid phase extraction, and paper‐based separation strips have been performed in terms of SERS for on‐site detecting target molecules in real‐life samples.…”

Section: Introductionmentioning

confidence: 99%

Lab‐on‐paper surface‐enhanced Raman spectroscopy platform based on self‐assembled Au@Ag nanocube monolayer for on‐site detection of thiram in soil

Lin

Liu

et al. 2019

J Raman Spectroscopy

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A paper-based surface-enhanced Raman spectroscopy (SERS) substrate was prepared by assembling Au@Ag nanocubes onto a patterned paper with the assistance of a mask paper by liquid-liquid interface self-assembly techniques. The paper-based SERS substrate was glued to the glass slide to construct a novel lab-on-paper SERS platform. This paper-based SERS sensor possesses a sample injecting zone together with a SERS detection zone in order that sample pretreatment and detection could be performed simultaneously.The SERS performance of this paper-based sensor was investigated by using 4-MBA as a probe molecule, and its enhancement factor as high as 0.56 × 10 5 could be obtained. Additionally, the SERS sensor demonstrated an excellent repeatability with the relative standard deviation for the variation from the spot-to-spot Raman intensity as low as 12.8%. Based on the superiority and functionality of this paper-based SERS platform, sensitive SERS quantitative analysis of thiram in soil could be achieved, which suggests its significant application prospects for the measurement of pesticides in soil without any pretreatment.

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Section: Introductionmentioning

confidence: 99%

Lab‐on‐paper surface‐enhanced Raman spectroscopy platform based on self‐assembled Au@Ag nanocube monolayer for on‐site detection of thiram in soil

Lin

Liu

et al. 2019

J Raman Spectroscopy

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“…In such scenarios, high-speed detection schemes are required for real-time monitoring of micro-flows. Numerous methods have been proposed in recent years, such as surface-enhanced Raman scattering spectroscopy [5,6], electrical impedance-based sensing [7,8], laser-induced fluorescing [9][10][11], and dynamic light scattering [12]. Among these techniques, laser-induced fluorescing becomes the most popular one due to its high sensitivity and specificity [13,14].…”

Section: Introductionmentioning

confidence: 99%

An opto-acousto-fluidic microscopic system with a high spatiotemporal resolution for microfluidic applications

et al. 2019

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In this work, we develop a new opto-acouto-fludic microsopic system, which employs a high-speed one-dimensional galvanometer scanner and an ultrafast pulse laser (600 kHz). The new system has achieved a high two-dimensional frame rate of up to 2500 Hz with a lateral resolution of 1.7 μm and an axial resolution of 36 μm at the imaging plane. To demonstrate the improved performance of the new system compared to our previous one, we carried out experiments to image the flowing droplets generated with T-junction and flow focusing configurations. We also successfully imaged dynamic migration of magneto particles subjected to non-uniform magnetic field in the microchannel. The results suggest that our new system has sufficient spatiotemporal resolutions to carry out studies for high throughput microfluidic applications.

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“…However, despite all the benefits of using microfluidics, because of the small volume handled, highly sensitive analytical techniques need to be integrated. There are several high-throughput detection techniques that have been successfully combined with microfluidic platforms: laser-induced fluorescence (LIF), mass spectrometry (MS), nuclear magnetic resonance (NMR), isothermal amplification for DNA detection, and so on [ 25 ]. All of these techniques provided promising results regarding sensitive detection in a microfluidic channel or reservoir, LIF being the most used and representative technique, as a result of its ultra-sensitivity, low cost, and ease of use.…”

Section: Introductionmentioning

confidence: 99%

Surface-Enhanced Raman Scattering Spectroscopy and Microfluidics: Towards Ultrasensitive Label-Free Sensing

Kant

Abalde‐Cela

2018

Biosensors

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Raman scattering and surface-enhanced Raman scattering (SERS) spectroscopy have demonstrated their potential as ultrasensitive detection techniques in the past decades. Specifically, and as a result of the flourishing of nanotechnology, SERS is nowadays one of the most powerful sensing techniques, not only because of the low detection limits that it can achieve, but also for the structural information that it offers and its capability of multiplexing. Similarly, microfluidics technology is having an increased presence not only in fundamental research, but also in the industry. The latter is because of the intrinsic characteristics of microfluidics, being automation, high-throughput, and miniaturization. However, despite miniaturization being an advantage, it comes together with the need to use ultrasensitive techniques for the interrogation of events happening in extremely small volumes. The combination of SERS with microfluidics can overcome bottlenecks present in both technologies. As a consequence, the integration of Raman and SERS in microfluidics is being investigated for the label-free biosensing of relevant research challenges.

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Surface-enhanced Raman spectroscopy (SERS) combined techniques for high-performance detection and characterization

Cited by 103 publications

References 127 publications

Lab‐on‐paper surface‐enhanced Raman spectroscopy platform based on self‐assembled Au@Ag nanocube monolayer for on‐site detection of thiram in soil

Lab‐on‐paper surface‐enhanced Raman spectroscopy platform based on self‐assembled Au@Ag nanocube monolayer for on‐site detection of thiram in soil

An opto-acousto-fluidic microscopic system with a high spatiotemporal resolution for microfluidic applications

Surface-Enhanced Raman Scattering Spectroscopy and Microfluidics: Towards Ultrasensitive Label-Free Sensing

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