Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments

Abstract

Surface-enhanced Raman spectroscopy (SERS) is a vibrational spectroscopy technique with sensitivity down to the single molecule level that provides fine molecular fingerprints, allowing for direct identification of target analytes.

Microfluidic synthesis of high-valence programmable atom-like nanoparticles for reliable sensing

“…These nanostructures are made of DNA-engineered nanohybirids, and thus in principle there are lots of DNA sequences (i.e., polyA-p1, polyA-p2 and their hybridization products) in SERS hotspots. 39,40 As revealed in Figure 3g and i, the characteristic Raman peaks related to DNA molecules are clearly observed. Typically, 730 cm -1 peak is assigned to the berating and the ring skeleton vibration modes of adenine (A); 787 cm -1 peak belongs to the ring breathing mode vibration of thymine (T) or cytosine (C); 1475 cm -1 peak is mainly assigned to symmetric stretching vibration of imidazole of guanine (G); 1640 cm -1 peak is assigned to T and C (mainly T).…”

SERS-Active Pattern in Silver-Ion-Exchanged Glass Drawn by Infrared Nanosecond Laser

“…The ratio of the intensities integrated over FWHMs of the corresponding peak was ~1.5 for the spectra averaged over 20 measurements. The was estimated by commonly used equation [ 47 ] with the known average thickness, 25 μm, and density, 6.3 µmol/mm 3 , of BPE crystallites [ 48 ]. The accurate estimate of the in the center of the dried droplet, where SERS signal was collected, should account the mass flow of molecules toward the periphery of the droplet during its evaporation, so-called “coffee-ring” effect [ 49 ].…”

Large‐Scale Sub‐1‐nm Random Gaps Approaching the Quantum Upper Limit for Quantitative Chemical Sensing

“…This uniform response enables quantitative sensing of molecules, which is considered as one of the major challenges for practical SERS sensing applications. [ 58–60 ]…”