Surface‐enhanced Raman spectroscopy: advancements and applications

Zhang, Tian

doi:10.1002/jrs.1378

Cited by 180 publications

(110 citation statements)

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“…2 The most well-known enhancement technique for Raman signals is surface-enhanced Raman spectroscopy (SERS), 3 where molecules on the metal substrates show anomalous enhancement of the Raman cross-section. In SERS, specific nano-structures of the metal surface are believed to play crucial roles in the local but remarkable Raman enhancement.…”

Section: Introductionmentioning

confidence: 99%

Electron-Enhanced Vibrational Spectroscopy: A Theoretical Approach

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Electron-Enhanced Vibrational Spectroscopy: A Theoretical Approach

et al. 2008

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“…[75] SERS has become a popular technique in multiple research areas including materials and electrochemistry, as well as in biomedical research areas. [76] SERS can be used to enhance native Raman signals, by close proximity to roughened metal surfaces. However, perhaps the more promising application is to probe for specific interactions, for example by detection of specific antigens [37] or enzyme activity [18,77].…”

Section: An Alternative Technique -Surface Enhanced Raman Spectroscopmentioning

confidence: 99%

Vibrational spectroscopy as a tool for studying drug-cell interaction: Could high throughput vibrational spectroscopic screening improve drug development?

Jamieson

Byrne²

2017

Vibrational Spectroscopy

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. (2017). Vibrational spectroscopy as a tool for studying drug-cell interaction: could high throughput vibrational spectroscopic screening improve drug development? Vibrational Spectroscopy, vol. 91, July, pp. 16-30. doi.org/10.1016/ j.vibspec.2016 Vibrational spectroscopy as a tool for studying drug-cell interaction: could high throughput vibrational spectroscopic screening improve drug development? AbstractVibrational spectroscopy is currently widely explored as a tool in biomedical applications. An area at the forefront of this field is the use of vibrational spectroscopy for disease diagnosis, ultimately aiming towards spectral pathology. However, while this field shows promising results, moving this technique into the clinic faces the challenges of widespread clinical trials and legislative approval. While spectral pathology has received a lot of attention, there are many other biomedical applications of vibrational spectroscopy, which could potentially be translated to applications with greater ease. A particularly promising application is the use of vibrational spectroscopic techniques to study the interaction of drugs with cells. Many studies have demonstrated the ability to detect biochemical changes in cells in response to drug application, using both infrared and Raman spectroscopy. This has shown potential for use in high throughput screening (HTS) applications, for screening of efficacy and mode of action of potential drug candidates, to speed up the drug discovery process. HTS is still a relatively new and growing area of research and, therefore, there is more potential for new techniques to move into and shape this field. Vibrational spectroscopic techniques come with many benefits over the techniques used currently in HTS, primarily based on fluorescence assays to detect specific binding interactions or phenotypes. They are label free, and an infrared or Raman spectrum provides a wealth of biochemical information, and therefore could reveal not only information about a specific interaction, but about how the overall biochemistry of a cell changes in response to application of a drug candidate. Therefore, drug mode of action could be elucidated. This review will investigate the potential for vibrational spectroscopy, particularly FTIR and Raman spectroscopy, to benefit the field of HTS and improve the drug development process. In addition to FTIR and Raman spectroscopy, surface enhanced Raman spectroscopy (SERS), coherent anti-Stokes Raman spectroscopy (CARS) and stimulated Raman spectroscopy (SRS), will be investigated as an alternative tool in the HTS process.

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“…Raman spectroscopy can be applied to any optically accessible sample, where a pre-treatment of the sample is not necessary. Additionally, measuring configurations that can accommodate target sizes from 1 µm 2 up to a few dm 2 at ranges from a few mm up to 1 km can be realized. However, while the specificity of Raman spectroscopy is very high, its sensitivity, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…The two most prominent approaches are the resonance Raman effect 1 and the surface-enhanced Raman scattering (SERS). 2 These two methods can enhance the intensity of the intrinsically weak Raman signals by several orders of magnitudes, thereby opening the possibility to investigate low-concentration samples. Moreover, resonance Raman and SERS spectra provide additional, very important information about the investigated system.…”

Section: Introductionmentioning

confidence: 99%