Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Resonance Raman Scattering (SERRS): A Review of Applications

McNay, Graeme; Eustace, David; Smith, W. Ewen; Faulds, Karen; Graham, Duncan

doi:10.1366/11-06365

Cited by 556 publications

(414 citation statements)

References 71 publications

(106 reference statements)

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“…[21] SERS is based on the enhancement of the incident and scattered electromagnetic field by plasmon excitation on irregular (metal) surfaces, typically composed of Au or Ag. [22][23][24] As it has single molecule sensitivity, SERS is increasingly applied for the characterization of biological samples. [25,26] In this respect, different types of SERS-substrates have been developed to obtain plasmon enhancement and record Raman spectra from (sub)cellular components down to the single biomolecule level.…”

Section: Introductionmentioning

confidence: 99%

Identification of Individual Exosome-Like Vesicles by Surface Enhanced Raman Spectroscopy

Stremersch

Marro

Pinchasik

et al. 2016

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152

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Exosome-like vesicles (ELVs) are a novel class of biomarkers that are receiving a lot of attention for the detection of cancer in an early stage. In this study the feasibility of using a Surface Enhanced Raman Spectroscopy (SERS) based method to distinguish between ELVs derived from different cellular origins is evaluated. A gold nanoparticle based shell is deposited on the surface of ELVs derived from cancerous and healthy cells which enhances the Raman signal while maintaining a colloidal suspension of individual vesicles. This nano-coating allows the recording of SERS spectra from single vesicles. By using Partial Least Square Discriminative Analysis (PLS-DA) on the obtained spectra, vesicles from different origin can be distinguished, even when present in the same mixture. This proof-of-concept study paves the way for non-invasive (cancer) diagnostic tools based on exosomal SERS fingerprinting in combination with multivariate statistical analysis.

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Section: Introductionmentioning

confidence: 99%

Identification of Individual Exosome-Like Vesicles by Surface Enhanced Raman Spectroscopy

Stremersch

Marro

Pinchasik

et al. 2016

Small

152

167

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“…This surfaceenhanced resonant Raman scattering effect is a benefit for producing a higher enhancement factor. 33,34 For AuNR, the longitude SPR peak at 780 nm matched the maximum absorption of DTTC (764 nm); thus only DTTC exhibited strong Raman intensity. Second, the coupling between the AuNR core and the external porous Ag/Au shell renders the inherent EM hot spots.…”

Section: Acs Applied Materials and Interfacesmentioning

confidence: 91%

Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property

Wang

et al. 2016

ACS Appl. Mater. Interfaces

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Surface-enhanced Raman scattering (SERS) tags draw much attention due to the ultrasensitivity and multiplex labeling capability. Recently, a new kind of SERS tags was rationally designed by encapsulating metal nanoparticles with phospholipid bilayers, showing great potential in theranostics. The lipid bilayer coating confers biocompatibility and versatility to changing surface chemistry of the tag; however, its "soft" feature may influence SERS signal stability, which is rarely investigated. Herein, we prepared phospholipidcoated AuNR@Ag/Au nanosphere SERS tags by using three different kinds of Raman reporters, i.e., thio-containing 4-nitrothiophenol (NT), nitrogen-containing hydrophobic chromophore cyanine 7 monoacid (Cy7), and alkyl chain− chromophore conjugate 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindodicarbocyanine (DiD). It was found that signal responses were different upon additional stimulation which the tags may encounter in theranostic applications including the presence of detergent Triton X-100, lipid membrane, and photothermal treatment. Living-cell imaging also showed signal changing distinction. The different SERS signal performances were attributed to the different Raman reporter releasing behaviors from the tags. This work revealed that Raman reporter structure determined signal stability of lipid-coated SERS tags, providing guidance for the design of stimulus responsive tags. Moreover, it also implied the potential of SERS technique for real time drug release study of lipid based nanomedicine.

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“…SERS is one technique that can enhance the Raman signal by several orders of magnitude by amplifying the electron cloud density around metallic nanostructures [99][100][101]. SERS signal enhancement is achieved through two distinct mechanisms: electromagnetic enhancement and chemical enhancement [100,[102][103][104]. For both mechanisms to occur simultaneously, an analyte must be adsorbed onto or reside very close to a dielectric (often metallic) surface [90].…”

Section: Surface Enhanced Raman Spectroscopy (Sers) and Its Potentialmentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

et al. 2017

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Point-of-care (POC) device development is a growing field that aims to develop low-cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, selfcontained, and can be used anywhere -from modern clinics to remote and low resource areas. In this review, surface enhanced Raman spectroscopy (SERS) is discussed as a solution to facilitating the translation of bioanalytical sensing to the POC. The potential for SERS to meet the widely accepted "ASSURED" (Affordable, Sensitive, Specific, Userfriendly, Rapid, Equipment-free, and Deliverable) criterion provided by the World Health Organization is discussed based on recent advances in SERS in vitro assay development. As SERS provides attractive characteristics for multiplexed sensing at low concentration limits with a high degree of specificity, it holds great promise for enhancing current efforts in rapid diagnostic testing. In outlining the progression of SERS techniques over the past years combined with recent developments in smart nanomaterials, high-throughput microfluidics, and low-cost paper diagnostics, an extensive number of new possibilities show potential for translating SERS biosensors to the POC.

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Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Resonance Raman Scattering (SERRS): A Review of Applications

Cited by 556 publications

References 71 publications

Identification of Individual Exosome-Like Vesicles by Surface Enhanced Raman Spectroscopy

Identification of Individual Exosome-Like Vesicles by Surface Enhanced Raman Spectroscopy

Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

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