Surface Enhanced Raman Scattering Revealed by Interfacial Charge-Transfer Transitions

Liu, Xiaohong; Jiang, Yu-Xiao; Zhang, Wei; Zhao, Zhigang

doi:10.1016/j.xinn.2020.100051

Cited by 142 publications

(125 citation statements)

References 138 publications

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“…We note that, despite the low performance on C 8 -BTBT films, a molecular-specific (i.e., among a sample of four analyte molecules) Raman enhancement is achieved on an organic-SERS platform 52 . Considering that undoped π-conjugated organic semiconductors have a low intrinsic free carrier density (10 13 carrier/cm 3 ) 17 , which is much lower than those of metals (10 22 –10 23 carrier/cm 3 ) 53 , electromagnetic contribution to SERS is an implausible mechanism for the current organic films. Therefore, as demonstrated in the previous reports by Lombardi et al 51 , 54 , 55 and our research groups 17 , 18 on (in)organic-SERS platforms, CT resonance occurred at the analyte/semiconductor interface should be the key player to enhance the polarizability derivative tensor for analyte vibrational modes, which consequently leads to Raman signal enhancements.…”

Section: Resultsmentioning

confidence: 99%

Enabling three-dimensional porous architectures via carbonyl functionalization and molecular-specific organic-SERS platforms

et al. 2021

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Molecular engineering via functionalization has been a great tool to tune noncovalent intermolecular interactions. Herein, we demonstrate three-dimensional highly crystalline nanostructured D(C7CO)-BTBT films via carbonyl-functionalization of a fused thienoacene π-system, and strong Raman signal enhancements in Surface-Enhanced Raman Spectroscopy (SERS) are realized. The small molecule could be prepared on the gram scale with a facile synthesis-purification. In the engineered films, polar functionalization induces favorable out-of-plane crystal growth via zigzag motif of dipolar C = O···C = O interactions and hydrogen bonds, and strengthens π-interactions. A unique two-stage film growth behavior is identified with an edge-on-to-face-on molecular orientation transition driven by hydrophobicity. The analysis of the electronic structures and the ratio of the anti-Stokes/Stokes SERS signals suggests that the π-extended/stabilized LUMOs with varied crystalline face-on orientations provide the key properties in the chemical enhancement mechanism. A molecule-specific Raman signal enhancement is also demonstrated on a high-LUMO organic platform. Our results demonstrate a promising guidance towards realizing low-cost SERS-active semiconducting materials, increasing structural versatility of organic-SERS platforms, and advancing molecule-specific sensing via molecular engineering.

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Section: Resultsmentioning

confidence: 99%

Enabling three-dimensional porous architectures via carbonyl functionalization and molecular-specific organic-SERS platforms

et al. 2021

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“…Due to this, the overall enhancement in the Raman scattering will reduce. Based on the literature, nanoparticles that have a size between 10-100 nm are more suitable for SERS experiments [34,35]. The shape of the nanoparticle is an additional key parameter to consider for improving the SERS performances in metal nanoparticle suspensions.…”

Section: Sers Substrates Used For Biosensingmentioning

confidence: 99%

Biosensing Using SERS Active Gold Nanostructures

et al. 2021

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Surface-enhanced Raman spectroscopy (SERS) has become a powerful tool for biosensing applications owing to its fingerprint recognition, high sensitivity, multiplex detection, and biocompatibility. This review provides an overview of the most significant aspects of SERS for biomedical and biosensing applications. We first introduced the mechanisms at the basis of the SERS amplifications: electromagnetic and chemical enhancement. We then illustrated several types of substrates and fabrication methods, with a focus on gold-based nanostructures. We further analyzed the relevant factors for the characterization of the SERS sensor performances, including sensitivity, reproducibility, stability, sensor configuration (direct or indirect), and nanotoxicity. Finally, a representative selection of applications in the biomedical field is provided.

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“…Raman scattering, for instance, since its discovery in the 1920s, has been widely employed as a powerful vibrational spectroscopy technology, capable of providing vibrational fingerprints intrinsic to analytes, thus enabling identification of molecules. 170 Recently, ML methods have been trained to recognize features in Raman (or SERS) spectra for the identity of an analyte by applying DL networks, including ANN, CNN, and fully convolutional network for feature engineering. 171 For example, Leong et al.…”

Section: Ai In Chemistrymentioning

confidence: 99%

Artificial intelligence: A powerful paradigm for scientific research

et al. 2021

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Artificial intelligence (AI) coupled with promising machine learning (ML) techniques well known from computer science is broadly affecting many aspects of various fields including science and technology, industry, and even our day-to-day life. The ML techniques have been developed to analyze high-throughput data with a view to obtaining useful insights, categorizing, predicting, and making evidence-based decisions in novel ways, which will promote the growth of novel applications and fuel the sustainable booming of AI. This paper undertakes a comprehensive survey on the development and application of AI in different aspects of fundamental sciences, including information science, mathematics, medical science, materials science, geoscience, life science, physics, and chemistry. The challenges that each discipline of science meets, and the potentials of AI techniques to handle these challenges, are discussed in detail. Moreover, we shed light on new research trends entailing the integration of AI into each scientific discipline. The aim of this paper is to provide a broad research guideline on fundamental sciences with potential infusion of AI, to help motivate researchers to deeply understand the state-of-the-art applications of AI-based fundamental sciences, and thereby to help promote the continuous development of these fundamental sciences.

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Surface Enhanced Raman Scattering Revealed by Interfacial Charge-Transfer Transitions

Cited by 142 publications

References 138 publications

Enabling three-dimensional porous architectures via carbonyl functionalization and molecular-specific organic-SERS platforms

Enabling three-dimensional porous architectures via carbonyl functionalization and molecular-specific organic-SERS platforms

Biosensing Using SERS Active Gold Nanostructures

Artificial intelligence: A powerful paradigm for scientific research

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