Surface-enhanced Raman scattering for rapid hematopoietic stem cell differentiation analysis

Al-Attar, Nebras; Daud, Hasbullah; Al-Majmaie, Rasoul; Zeulla, Domonic; Al-Rubeai, Mohameed; Rice, James H.

doi:10.1364/ao.57.00e184

Cited by 21 publications

(16 citation statements)

References 58 publications

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“…Surface-enhanced Raman spectroscopy (SERS) is a sensitive and nondestructive vibrational spectroscopy technique used for the detection of chemical and biological molecules at very low concentrations. Research has focused on the development of novel SERS platforms, which would enable detection of molecules down to the single-molecule level with applications in the field of medicine, biology, chemistry, environmental science, and security. − Traditionally the technique is applied by adsorbing analyte molecules on rough noble-metal (typically gold or silver) substrates with features in the nanometer scale. , Two main mechanisms for the enhancement of Raman scattering intensity can be distinguished: electromagnetic enhancement and chemical enhancement. Strong electromagnetic enhancement (enhancement factor (EF) ∼ 10 6 ) originates from local electromagnetic field magnification due to the excitation of a localized surface plasmon resonance (LSPR) in the metal nanoparticle. , Chemical enhancement is a weaker process (EF ∼ 10 3 ) which is usually assigned to the charge transfer between the substrate and analyte molecule and highly depends on the electronic states in the system …”

Section: Introductionmentioning

confidence: 99%

Oxygen Incorporation-Induced SERS Enhancement in Silver Nanoparticle-Decorated ZnO Nanowires

Fularz

Almohammed

Rice

2020

ACS Appl. Nano Mater.

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Surface-enhanced Raman spectroscopy (SERS) is a sensitive and nondestructive technique used for the detection of molecules, traditionally applied on noble-metal or semiconductor substrates. Point defect introduction has been applied to increase the enhancement of semiconductor templates due to more efficient charge transfer; however, they are still limited by low detection sensitivity and inferior SERS enhancement. Here we propose a universal approach of oxygen incorporation into metal oxide nanowire/metal nanoparticle templates that allows for greater SERS enhancement due to localized surface plasmon resonance excitation, point defect-induced optical gap shrinking, and wettability change of the substrate. We report up to 5-fold Raman relative peak intensity enhancement after annealing-induced oxygen introduction. This approach is applied to defect formation in metal oxide semiconductor nanowires such as ZnO, WO 3 , TiO 2 , and NiO and is applicable for a wide variety of probe molecules, making the method suitable for medical, security, and environmental applications.

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Section: Introductionmentioning

confidence: 99%

Oxygen Incorporation-Induced SERS Enhancement in Silver Nanoparticle-Decorated ZnO Nanowires

Fularz

Almohammed

Rice

2020

ACS Appl. Nano Mater.

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“…If molecules are located on the surface of metallic NPs, the Raman scattering signal is remarkably enhanced, which is defined as SERS (Fig. 2B) [70,[74][75][76][77][78]. SERS technology offers a new strategy for both biomolecule detection and intracellular imaging [61].…”

Section: Lspr-or Sers-based Diagnosismentioning

confidence: 99%

Noble metal nanomaterials for the diagnosis and treatment of hematological malignancies

Huang¹,

Mahmudul²,

Li³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background:Recently, the incidence of hematological malignancy, such as various leukemias, multiple myeloma and lymphoma, has revealed an increasing tendency, exhibiting a major impact on human health. Most of the available anti-cancer drugs, however, possess high non-targeted accumulation, dosage-associated toxicity, fast elimination, and lack specificity towards tumors, which restrict their utilization in clinical therapy. This extends also to cancer diagnosis where there is a lack of predictive biomarkers. Object: Noble metal nanomaterials (NM NMs) have the potential to overcome these shortcomings due to several characteristics including ease of synthesis, ultra-small size, easy surface modification and specific physicochemical properties. At present, gold-, silver-and platinumbased nanomaterials have been employed in the tracing and treatment of hematopoietic tumors through direct individual endocytosis or in innovative drug delivery systems (DDS) by conjugation with other targeting biomolecules. Purpose: In this mini review, we focus on the use of localized surface plasmon resonance (LSPR)-/surface-enhanced Raman scattering (SERS)-and fluorescence-based diagnosis of NM NMs in the hematological malignancies. Furthermore, the treatment of hematological malignancies utilized the NM NMs or NM NMs-based therapy technology in the chemotherapy, targeted therapy, and photothermal therapy are depicted in depth. The construction of effective and promising NM NMs or NM NMs-dependent theranostic methodology has the potential to provide interdisciplinary knowledge in the development of clinical tracing, diagnosis and treatment of refractory hematological diseases.

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“…One frequently used vibrational spectroscopy method is Raman scattering [1][2][3][4]. In Raman spectroscopy, only approximately one in 10 6 photons converted into stokes scattering light producing a weak analytical signal intensity [5][6][7][8][9][10]. However, the use of nanostructured materials can increase the efficiency of Raman scattering through plasmonic enhancement to enable single-molecule Raman detection [11,12].…”

Section: Introductionmentioning

confidence: 99%

Hybrid composite based on conducting polymers and plasmonic nanomaterials applied to catalysis and sensing

Alanazi

Rice

2022

Mater. Res. Express

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Combining plasmonic and semiconductors offers significant potential in creating sensing and photocatalytic devices. Nanocomposites including both metals and semiconductors can control the charge states in the metals that can enhance catalysis activity along with plasmon-enhanced spectroscopy. Here we demonstrate the use of conducting polymer materials with plasmonic nanomaterials to boost 5-fold plasmon-enhanced Raman scattering spectroscopy signal strength and support oxidation of target molecules through supporting charge transfer processes. This work demonstrates the use of conducting polymers as a semiconductor platform to support plasmonic catalysis and sensing.

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Surface-enhanced Raman scattering for rapid hematopoietic stem cell differentiation analysis

Cited by 21 publications

References 58 publications

Oxygen Incorporation-Induced SERS Enhancement in Silver Nanoparticle-Decorated ZnO Nanowires

Oxygen Incorporation-Induced SERS Enhancement in Silver Nanoparticle-Decorated ZnO Nanowires

Noble metal nanomaterials for the diagnosis and treatment of hematological malignancies

Hybrid composite based on conducting polymers and plasmonic nanomaterials applied to catalysis and sensing

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