Surface-enhanced Raman scattering biomedical applications of plasmonic colloidal particles

Abalde‐Cela, Sara; Aldeanueva-Potel, Paula; Mateo-Mateo, Cintia; Rodríguez‐Lorenzo, Laura; Alvarez-Puebla, Ramón A.; Liz‐Marzán, Luis M.

doi:10.1098/rsif.2010.0125.focus

Cited by 198 publications

(182 citation statements)

References 151 publications

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“…For the sample obtained by adding 150 μL of AgNO 3 , the Raman intensity at 1619 cm −1 was 28 times higher than that for AuNR@mSiO 2 ( Figure S8, Supporting Information), which was attributed to the much greater Raman enhancing ability of Ag than Au. 37 The SERS signal variations could also be dynamically monitored during the Ag coating process. Figure 3d shows a typical set of SERS spectra collected at different time intervals in one reaction system containing 150 μL of AgNO 3 .…”

Section: Research Articlementioning

confidence: 99%

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Lin

Wang

Sun

et al. 2015

ACS Appl. Mater. Interfaces

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ABSTRACT:The Raman enhancing ability of noble metal nanoparticles (NPs) is an important factor for surface enhanced Raman scattering (SERS) substrate screening, which is generally evaluated by simply mixing as-prepared NPs with Raman reporters for Raman signal measurements. This method usually leads to incredible results because of the NP surface coverage nonuniformity and reporter-induced NP aggregation. Moreover, it cannot realize in situ, continuous SERS characterization. Herein, we proposed a dynamic SERS monitoring strategy for NPs with precisely tuned structures based on a simplified spatially confined NP growth method. Gold nanorod (AuNR) seed NPs were coated with a mesoporous silica (mSiO 2 ) shell. The permeability of mSiO 2 for both reactive species and Raman reporters rendered the silver overcoating reaction and SERS indication of NP growth. Additionally, the mSiO 2 coating ensured monodisperse NP growth in a Raman reporter-rich reaction system. Moreover, "elastic" features of mSiO 2 were observed for the first time, which is crucial for holding the growing NP without breakage. This feature makes the mSiO 2 coating adhere to metal NPs throughout the growing process, providing a stable Raman reporter distribution microenvironment near the NPs and ensuring that the substrate's SERS ability comparison is accurate. Three types of NPs, i.e., core−shell Au@AgNR@mSiO 2 , Au@AuNR@mSiO 2 , and yolk−shell Au@void@AuNR@mSiO 2 NPs, were synthesized via core−shell overgrowth and galvanic replacement methods, showing the versatility of the approach. The living cell SERS labeling ability of Au@AgNR@mSiO 2 -based tags was also demonstrated. This strategy addresses the problems of multiple batch NP preparation, aggregation, and surface adsorption differentiation, which is a breakthrough for the dynamic comparison of SERS ability of metal NPs with precisely tuned structures and optical properties.

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Section: Research Articlementioning

confidence: 99%

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Lin

Wang

Sun

et al. 2015

ACS Appl. Mater. Interfaces

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“…In contrast to conventional methods stated earlier, higher detection limits in addition to a complete structural characterisation of the target molecule can be achieved with SERS [18] without the need for staining or expressing fluorogenic proteins. It has also been demonstrated that SERS can be applied to living cells in order to monitor cellular functions [19], cell response to stress [20] and apoptosis [21].…”

Section: Introductionmentioning

confidence: 97%

Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes

Huefner

Septiadi

Wilts

et al. 2014

Methods

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Understanding uptake of nanomaterials by cells and their use for intracellular sensing is important for studying their interaction and toxicology as well as for obtaining new biological insight. Here, we investigate cellular uptake and intracellular dynamics of gold nanoparticles and demonstrate their use in reporting chemical information from the endocytotic pathway and cytoplasm. The intracellular gold nanoparticles serve as probes for surface-enhanced Raman spectroscopy (SERS) allowing for biochemical characterisation of their local environment. In particular, in this work we compare intracellular SERS using non-functionalised and functionalised nanoparticles in their ability to segregate different but closely related cell phenotypes. The results indicate that functionalised gold nanoparticles are more efficient in distinguishing between different types of cells. Our studies 2 pave the way for understanding the uptake of gold nanoparticles and their utilisation for SERS to give rise to a greater biochemical understanding in cell-based therapies.

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“…Thirdly, it remains very hard for us to quantify the SERS intensities as currently no tool or model is available to us for means of calculation [41]. The SERS intensities will depend several factors such as particle sizes, Raman cross section [42] and concentration of the AuNPs [43], which will make it too complex for us to control [44,45].…”

Section: Etching Rates and Diffusion Coefficients Of Cyanidementioning

confidence: 99%

Probing Ionic Diffusion Dynamics through the Modulation of Polymer Shell Using Surface-Enhanced Raman Spectroscopy

Song¹,

Phua²,

Xu³

2017

J Nanomed Nanotechnol

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Surface-enhanced Raman scattering biomedical applications of plasmonic colloidal particles

Cited by 198 publications

References 151 publications

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes

Probing Ionic Diffusion Dynamics through the Modulation of Polymer Shell Using Surface-Enhanced Raman Spectroscopy

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