Surface-Enhanced Raman Scattering and Fluorescence-Based Dual Nanoprobes for Multiplexed Detection of Bacterial Pathogens

Jang, Hyungil; Hwang, Eun Young; Kim, Y.; Choo, Jaebum; Jeong, Jihoon; Lim, Dong Woo

doi:10.1166/jbn.2016.2309

Cited by 21 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The magnetic SERS technique is one method for the diagnosis of infectious diseases caused by pathogens, such as bacteria or viruses [ 25 , 34 , 104 , 105 ]. Compared with other methods—including polymerase chain reaction, enzyme-linked immunosorbent assay, and culture and colony counting of bacteria—magnetic SERS has advantages, such as simpler sample preparation requirements, improved sensitivity, and rapid and multiplexed detection [ 104 ]. Additionally, magnetic properties assist in the concentration of the target to improve separation [ 15 ], accuracy, and sensitivity [ 106 ].…”

Section: Bioapplication Of Mppsmentioning

confidence: 99%

“…Additionally, magnetic properties assist in the concentration of the target to improve separation [ 15 ], accuracy, and sensitivity [ 106 ]. Typically, pathogens can be determined directly [ 34 , 106 ], or indirectly via specific capture with antibodies [ 24 , 104 , 107 , 108 , 109 ] or aptamers [ 25 , 110 ]. The MPPs used can be magnetic plasmonic core-shell mono particles [ 24 ] or dual particles including magnetic and plasmonic particles [ 25 ].…”

Section: Bioapplication Of Mppsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Surface-Enhanced Raman Scattering Magnetic Plasmonic Particles for Bioapplications

et al. 2021

View full text Add to dashboard Cite

The surface-enhanced Raman scattering (SERS) technique, that uses magnetic plasmonic particles (MPPs), is an advanced SERS detection platform owing to the synergetic effects of the particles’ magnetic and plasmonic properties. As well as being an ultrasensitive and reliable SERS material, MPPs perform various functions, such as aiding in separation, drug delivery, and acting as a therapeutic material. This literature discusses the structure and multifunctionality of MPPs, which has enabled the novel application of MPPs to various biological fields.

show abstract

Section: Bioapplication Of Mppsmentioning

confidence: 99%

Section: Bioapplication Of Mppsmentioning

confidence: 99%

Recent Advances in Surface-Enhanced Raman Scattering Magnetic Plasmonic Particles for Bioapplications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…As a result of its low background, high sensitivity, high specificity, and the ease for quantitative analysis, fluorescent detection has been widely combined with MNPs for bacterial detection, since it is an emerging trend for the development of efficient biosensors for clinical use (Kwon et al, 2013; Tang et al, 2013; Chen et al, 2015c; Qin et al, 2016). MNPs with different fluorescent labels, such as Au (Kwon et al, 2013), rare earth-doped upconversion NPs (Qin et al, 2016), and the other labels (Jang et al, 2016; Shelby et al, 2017; Gontero et al, 2018) were conjugated with antibody or other target molecules for the detection of pathogenic bacteria. In these composite NPs, MNPs were used to capture and separate bacteria.…”

Section: Mnps-based Composites For Bacterial Detection In Vitromentioning

confidence: 99%

Applications of Iron Oxide-Based Magnetic Nanoparticles in the Diagnosis and Treatment of Bacterial Infections

Akakuru

Zheng

et al. 2019

Front. Bioeng. Biotechnol.

118

View full text Add to dashboard Cite

Diseases caused by bacterial infections, especially drug-resistant bacteria have seriously threatened human health throughout the world. It has been predicted that antimicrobial resistance alone will cause 10 million deaths per year and that early diagnosis and therapy will efficiently decrease the mortality rate caused by bacterial infections. Considering this severity, it is urgent to develop effective methods for the early detection, prevention and treatment of these infections. Until now, numerous efforts based on nanoparticles have been made to detect and kill pathogenic bacteria. Iron oxide-based magnetic nanoparticles (MNPs), as potential platforms for bacteria detection and therapy, have drawn great attention owing to their magnetic property. These MNPs have also been broadly used as bioimaging contrast agents and drug delivery and magnetic hyperthermia agents to diagnose and treat bacterial infections. This review therefore overviews the recent progress on MNPs for bacterial detection and therapy, including bacterial separation and enrichment in vitro , bacterial infection imaging in vivo , and their therapeutic activities on pathogenic bacteria. Furthermore, some bacterial-specific targeting agents, used to selectively target the pathogenic bacteria, are also introduced. In addition, the challenges and future perspective of MNPs for bacterial diagnosis and therapy are given at the end of this review. It is expected that this review will provide a better understanding toward the applications of MNPs in the detection and therapy of bacterial infections.

show abstract

“…SERS was discovered in 1970s and has attracted lots of attention since then. [50][51][52] Metal NPs, especially Ag NPs, are the most commonly used SERS substrates due to their intense SPR and strong enhancement capacity for Raman scattering. The magnitude of SERS enhancement depends on the size, shape, orientation, and aggregation of metal nanostructures.…”

Section: Metal Nps As the Surface-enhanced Raman Scattering (Sers) Sumentioning

confidence: 99%

Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection

Yuan

Ding

Yang

et al. 2018

Adv Healthcare Materials

165

View full text Add to dashboard Cite

Infectious diseases caused by pathogenic bacteria, especially multidrug‐resistant bacteria, and their global spreading have become serious public health concerns. Early diagnosis and effective therapy can efficiently prevent deterioration and further spreading of the infections. There is an urgent need for sensitive, selective, and facile diagnosis as well as therapeutically potent treatment. The emergence of nanotechnology has provided more options for diagnosis and treatments of bacterial infections. Metal nanoparticles and metal oxide nanoparticles have drawn intense attention owing to their unique optical, magnetic, and electrical properties. These versatile metal‐based nanoparticles have great potential for selective detection of bacteria and/or therapy. This review gives an overview of recent efforts on developing various metal‐based nanoparticles for bacterial detection and infection therapy. It begins with an introduction of fundamental concepts and mechanisms in designing diagnostic and therapeutic strategies. Representative achievements are selected to illustrate the proof‐of‐concept in vitro and in vivo applications. A brief discussion of challenges and perspective outlook in this field is provided at the end of this review.

show abstract

Surface-Enhanced Raman Scattering and Fluorescence-Based Dual Nanoprobes for Multiplexed Detection of Bacterial Pathogens

Cited by 21 publications

References 0 publications

Recent Advances in Surface-Enhanced Raman Scattering Magnetic Plasmonic Particles for Bioapplications

Recent Advances in Surface-Enhanced Raman Scattering Magnetic Plasmonic Particles for Bioapplications

Applications of Iron Oxide-Based Magnetic Nanoparticles in the Diagnosis and Treatment of Bacterial Infections

Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection

Contact Info

Product

Resources

About