Surface-enhanced infrared absorption studies towards a new optical biosensor

Leidner, Lothar; Stab, Julia; Adam, Jennifer T; Gauglitz, Günter

doi:10.3762/bjnano.7.166

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…Originally poor spectra can be magnified by surface-enhanced infrared absorption (SEIRA). Thus, the transfer of RIfS from the visible to the mid-infrared could be of advantage [385,386].…”

Section: Reflectometric Interference Spectroscopymentioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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“…Originally poor spectra can be magnified by surface-enhanced infrared absorption (SEIRA). Thus, the transfer of RIfS from the visible to the mid-infrared could be of advantage [385,386].…”

Section: Reflectometric Interference Spectroscopymentioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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“…Surface plasmons are important and widely used in photolithography [ 1 , 2 , 3 , 4 , 5 , 6 ], surface-enhanced Raman scattering (SERS) [ 7 , 8 , 9 , 10 ], surface-enhanced infrared absorption (SEIRA) [ 11 ], photocatalysis [ 12 , 13 ], and other fields due to their excellent optical properties. It propagates at the interface of the metal and medium.…”

Section: Introductionmentioning

confidence: 99%

A Potential Plasmonic Biosensor Based Asymmetric Metal Ring Cavity with Extremely Narrow Linewidth and High Sensitivity

Zhang

2021

Sensors

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To achieve high sensitivity and multi-mode sensing characteristics based on the plasmon effect, we explored a high-sensitivity refractive index sensor structure with narrow linewidth and high absorption characteristics based on theoretical analysis. The sensor structure is composed of periodic asymmetric ring cavity array, spacer layer and metal thin-film layer. The reflection spectrum of this structure shows six resonance modes in the wavelength range from visible to near-infrared. The sensor performance was optimized based on the change of the sensor structure parameters combining the simulation data, and the results shown that this kind of asymmetric laminated structure sensor has good sensing performance. In theory, it can be combined with microfluidic technology to achieve sensing detection of diverse test samples, multi-mode and multi-component, which has great potential in the field of biosensing.

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Strategies to improve performances of LSPR biosensing: Structure, materials, and interface modification

Zhang

2021

Biosensors and Bioelectronics

127

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Surface-enhanced infrared absorption studies towards a new optical biosensor

Cited by 7 publications

References 22 publications

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

A Potential Plasmonic Biosensor Based Asymmetric Metal Ring Cavity with Extremely Narrow Linewidth and High Sensitivity

Strategies to improve performances of LSPR biosensing: Structure, materials, and interface modification

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