Surface enhanced hyper Raman scattering (SEHRS) and its applications

Madzharova, Fani; Heiner, Zsuzsanna; Kneipp, Janina

doi:10.1039/c7cs00137a

Cited by 68 publications

(67 citation statements)

References 126 publications

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“…[16][17][18][19][20][21] Due to different selection rules of the hyper Raman process, SEHRS allows to collect complementary vibrational information, revealing infrared-active or even "silent" vibrational modes. 22 The surface enhancement of hyper Raman scattering signals benefits specifically from their nonlinear scaling with the excitation field intensity, [23][24][25] and also from an altered chemical enhancement.…”

Section: Introductionmentioning

confidence: 99%

Surface-enhanced hyper Raman hyperspectral imaging and probing in animal cells

et al. 2017

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scattering, that is, spontaneous, two-photon excited Raman scattering, of organic molecules becomes strong when it occurs as surface-enhanced hyper Raman scattering (SEHRS), in the proximity of plasmonic nanostructures. Its advantages over one-photon excited surface-enhanced Raman scattering (SERS) include complementary vibrational information resulting from different selection rules, probing of very small focal volumes, and beneficial excitation with long wavelengths. Here, imaging of macrophage cells by SEHRS is demonstrated, using SEHRS labels consisting of silver nanoparticles and two different molecules, 2-naphthalenethiol and para-mercaptobenzoic acid, that are excited offresonance. The vibrational signatures of the molecules are discriminated using hyperspectral analysis and provide information about the subcellular localization of the SEHRS probes. The SEHRS based hyperspectral imaging approach presented here uses principal component analysis (PCA) to localize the reporter molecules inside the cells and is augmented by hierarchical cluster analysis (HCA). The high sensitivity of SEHRS spectra with respect to small environmental changes can be utilized for mapping of physiological parameters in the endosomal system of the cells. This is illustrated by discussing the spatial distribution of endosomes of varying pH inside the cytosol.

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Section: Introductionmentioning

confidence: 99%

Surface-enhanced hyper Raman hyperspectral imaging and probing in animal cells

et al. 2017

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“…Comparisons of SERS and surface‐enhanced hyper Raman scattering (SEHRS) of adenine adsorbed on silver colloids reported significant differences in relative band intensities (Figure ) . Since it has been recently used for analysis of several amino acids, SEHRS may be useful for exploring the adsorption orientation of adenine due to its high sensitivity to adsorption orientation relative to conventional SERS .…”

Section: Discussionmentioning

confidence: 99%

The Controversial Orientation of Adenine on Gold and Silver

Harroun

2018

ChemPhysChem

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In which orientation does adenine adsorb on gold and silver surfaces? This question has been a matter of debate for over 30 years. Since the dawn of surface-enhanced Raman spectroscopy (SERS); it and other techniques such as tip-enhanced Raman spectroscopy (TERS), surface-enhanced infrared absorption spectroscopy (SEIRAS), scanning tunneling microscopy (STM), density functional theory (DFT) simulations, and more, have been used in many attempts to answer this seemingly straightforward, yet controversial, question. Herein, the timeline and recent advances on this topic are explored, and the frequently contradictory findings are put into context and discussed.

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“…As an example, the spontaneous two‐photon‐excited Raman process, termed HRS, is governed by different selection rules than the (conventional) spontaneous one‐photon‐excited RS. Both HRS and RS can be enhanced in the local fields of plasmonic nanostructures, resulting in surface enhanced hyper Raman scattering (SEHRS) and surface enhanced Raman scattering (SERS) spectra, respectively. While imaging based on vibrational spectra gives detailed molecular structure, other nonlinear optical signals, such as SHG, are less specific but lead to information about the microscopic morphology of a sample.…”

Section: Introductionmentioning

confidence: 99%

Gold‐ and Silver‐Coated Barium Titanate Nanocomposites as Probes for Two‐Photon Multimodal Microspectroscopy

Madzharova

Nodar

Živanović

et al. 2019

Adv Funct Materials

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Improved multiphoton-excited imaging and microspectroscopy require nanoprobes that can give different nonlinear optical signals. Here, composite nanostructures with a barium titanate core and a plasmonic moiety at their surface are synthesized and characterized. It is found that the core provides a high second-order nonlinear susceptibility for sensitive second harmonic generation (SHG) imaging in living cells. As a second function in the twophoton regime, the plasmonic part yields high local fields for resonant and nonresonant surface enhanced hyper Raman scattering (SEHRS). SEHRS complements the one-photon surface enhanced Raman scattering (SERS) spectra that are also enhanced by the plasmonic shells. Barium titanate silver core-shell (Ag@BaTiO 3 ) composites are specifically suited for SEHRS and SHG excited at 1064 nm, while gold at barium titanate (Au@BaTiO 3 ) nanoparticles can be useful in a combination of SHG and SERS at lower wavelengths, here at 785 nm and 850 nm. The theoretical models show that the optical properties of the BaTiO 3 dielectric core depend on probing frequency, shape, size, and plasmonic properties of the surrounding gold nanoparticles so that they can be optimized for a particular type of experiment. These versatile, tunable probes give new opportunities for combined multiphoton probing of morphological structure and chemical properties of biosystems.very attractive in laser microspectroscopy and imaging. They include two-photonexcited fluorescence, [3] second harmonic generation (SHG), [4] stimulated Raman scattering [5] and coherent anti-Stokes Raman scattering [6] microscopies, and imaging based on spontaneous hyper Raman scattering (HRS). [7] Nonlinear processes are attractive in microscopy and spectroscopy since they can be excited with light in the near-infrared, which offers several advantages. The latter include deep tissue penetration capability, reduced photo damage due to the lower photon energy, and spatially more confined probed volume, which can result in an improved lateral resolution. [8] Nevertheless, when multiphoton-excited processes are complemented with their one-photon-excited counterparts, this can yield unprecedented structural information from a sample. As an example, the spontaneous twophoton-excited Raman process, termed HRS, is governed by different selection rules than the (conventional) spontaneous one-photon-excited RS. Both HRS and RS can be enhanced in the local fields of plasmonic nanostructures, resulting in surface enhanced hyper Raman scattering (SEHRS) [9] and surface enhanced Raman scattering (SERS) spectra, respectively. While imaging based on vibrational spectra gives detailed molecular structure, other nonlinear optical signals, such as SHG, are less specific but lead to information about the microscopic morphology of a sample. SHG is a two-photon process, where a

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Surface enhanced hyper Raman scattering (SEHRS) and its applications

Cited by 68 publications

References 126 publications

Surface-enhanced hyper Raman hyperspectral imaging and probing in animal cells

Surface-enhanced hyper Raman hyperspectral imaging and probing in animal cells

The Controversial Orientation of Adenine on Gold and Silver

Gold‐ and Silver‐Coated Barium Titanate Nanocomposites as Probes for Two‐Photon Multimodal Microspectroscopy

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