Surface engineering of hollow gold nanoparticle with mesenchymal stem cell membrane and MUC-1 aptamer for targeted theranostic application against metastatic breast cancer

Taghavi, Sahar; Tabasi, Hamed; Zahiri, Mahsa; Abnous, Khalil; Taghdisi, Seyed Mohammad; Nekooei, Sirous; Nekooei, Negar; Ramezani, Mohammad; Alibolandi, Mona

doi:10.1016/j.ejpb.2023.04.014

Cited by 22 publications

(8 citation statements)

References 64 publications

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“… 147 HGNs DOX MUC-1 aptamer Breast cancer Targeted drug delivery and pH-responsive drug release. 148 Abbreviations : MTX, methotrexate; PDA, polydopamine nanoparticles; SN38, 7-ethyl-10-hydroxycamptothecin; ZnPC, zinc phthalocyanine; MC540, merocyanine 540; LNP, lipidoid nanoparticle; CXCL12α, a chemokine. …”

Section: Bndds Based On Natural Cmsmentioning

confidence: 99%

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Han,

Gong,

Yang

et al. 2024

IJN

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With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from the body, and nonspecific targeting, which have hampered their clinical application. Therefore, the development of novel drug delivery systems with improved biocompatibility and high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug delivery system (BNDDS) has become a research hotspot focus in the field of life sciences. This new biomimetic platform uses bio-nanotechnology to encapsulate synthetic NPswithin biomimetic membrane, organically integrating the low immunogenicity, low toxicity, high tumor targeting, good biocompatibility of the biofilm with the adjustability and versatility of the nanocarrier, and shows promising applications in the field of precision tumor therapy. In this review, we systematically summarize the new progress in BNDDS used for optimizing drug delivery, providing a theoretical reference for optimizing drug delivery and designing safe and efficient treatment strategies to improve tumor treatment outcomes.

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Section: Bndds Based On Natural Cmsmentioning

confidence: 99%

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Han,

Gong,

Yang

et al. 2024

IJN

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“…While not a widely adopted strategy for this purpose, freeze-thaw has been employed in certain experiments [28,37,40,53,59,78,86,93,94,105,106]. This technique involves subjecting the cell suspension to multiple cycles of freezing and thawing, with the addition of only a phosphatase inhibitor to the suspension.…”

Section: Freeze-thawmentioning

confidence: 99%

“…These objectives ranged from chemotherapy to inhibiting molecular pathways, silencing genes, immune adjuvation (Figure 3a) or photosensitizing. The loaded substances included dexamethasone [22,35,47,89], doxorubicin [6,24,29,33,34,40,46,64,68,78,81,83,85,91,92,106], paclitaxel [62,74,76,94], cisplatin (Pt) [58], docetaxel [90], dacarbazine [55], SN-38 (primary active derivative of the pivotal chemotherapeutic agent CPT-11, with enhanced efficacy in colorectal cancer) [98], methyl-triazeno-imidazole-carboxamide (MTIC) [66], KLA peptide (KLAKLAKKLAK-LAK) [104], temozolomide [63,65], epirubicin [50], bortezomib (Figure 3b) [25], carfilzomib (CFZ) [102], ABT-737 [45], rapamycin [100], TPI-1 [33], mefuparib hydrochloride [6], hydroxychloroquine [60], NLG919 [53], aPD-1 [61], MLN4924 ...…”

Section: Cargoes Loaded Into the Particlesmentioning

confidence: 99%

“…Sonication proved to be nearly as prevalent as extrusion, featuring independently in almost half of the procedures [23,24,27,[29][30][31][32][33]35,37,38,40,47,50,52,54,57,59,68,71,72,78,79,82,85,86,89,99,101,102,104,107] and in combination with extrusion in some others [21,22,39,43,48,60,61,70,74,81,83,87,88,91,94,98,103]. The coating method typically involved sonication of the mixture of nanoparticles and membrane fragments in a bath sonicator for varying durations, of 2 ...…”

Section: Sonicationmentioning

confidence: 99%

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Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics

Fernández-Borbolla,

García-Hevia,

Fanarraga

2024

IJMS

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Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle delivery faces challenges such as a short circulation time and immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested as a practical alternative. The production process involves three main stages: cell lysis and membrane fragmentation, membrane isolation, and nanoparticle coating. Cell membranes are typically fragmented using hypotonic lysis with homogenization or sonication. Subsequent membrane fragments are isolated through multiple centrifugation steps. Coating nanoparticles can be achieved through extrusion, sonication, or a combination of both methods. Notably, this analysis reveals the absence of a universally applicable method for nanoparticle coating, as the three stages differ significantly in their procedures. This review explores current developments and approaches to cell membrane-coated nanoparticles, highlighting their potential as an effective alternative for targeted drug delivery and various therapeutic applications.

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“…Thanks to the hollow gold nano platform that enabled CT scan imaging in 4T1-laden cancer cells in vivo. The designed paradigm outbursted the theranostic scope of gold nanoparticles [ 177 ].…”

Section: Theranostic Applications Of Gold Nanoparticlesmentioning

confidence: 99%

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Kesharwani

Liang

et al. 2023

Mol Cancer

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Cancer is a grievous disease whose treatment requires a more efficient, non-invasive therapy, associated with minimal side effects. Gold nanoparticles possessing greatly impressive optical properties have been a forerunner in bioengineered cancer therapy. This theranostic system has gained immense popularity and finds its application in the field of molecular detection, biological imaging, cancer cell targeting, etc. The photothermal property of nanoparticles, especially of gold nanorods, causes absorption of the light incident by the light source, and transforms it into heat, resulting in tumor cell destruction. This review describes the different optical features of gold nanoparticles and summarizes the advance research done for the application of gold nanoparticles and precisely gold nanorods for combating various cancers including breast, lung, colon, oral, prostate, and pancreatic cancer.

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Surface engineering of hollow gold nanoparticle with mesenchymal stem cell membrane and MUC-1 aptamer for targeted theranostic application against metastatic breast cancer

Cited by 22 publications

References 64 publications

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

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