Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy

Sasirekha, R.; Sheena, Thankaraj Salammal; Deepika, M; Santhanam, P.; Townley, Helen E.; Jeganathan, K.; Kumar, Sundarrajan Dinesh; Premkumar, Kumpati

doi:10.1016/j.msec.2018.09.009

Cited by 30 publications

(25 citation statements)

References 46 publications

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“…Moreover, diatom frustules modified with DOPA/Fe 3 O 4 (dopamine-terminated Fe 3 O 4 NPs) could control an external magnetic field through their magnetic properties [ 46 ]. In research in this regard, Sasirokha et al performed the chitosan functionalization of Amphora subtropica for doxorubicin (DOX) loading and release [ 47 ]. In addition, Janićijević et al reported that diatomite modified with aluminum sulfate is an effective carrier for diclofenac sodium, providing higher adsorbent loading and extended release compared to control [ 48 ].…”

Section: Microalgal-based Micro-/nanocarriers In Drug Deliverymentioning

confidence: 99%

“…In a study in this regard, Ragendran et al used Amphora subtropica functionalized with chitosan for the delivery of DOX, reporting the improvement of drug delivery to cancer cells. Furthermore, cytotoxic effects were observed to enhance compared to free DOX due to the sustained drug release from Chi@AF-DOX [ 47 ] (Table 1 ).…”

Section: Diatom-based Nanocarriers In Cancer Therapymentioning

confidence: 99%

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Microalgae: therapeutic potentials and applications

et al. 2021

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Recently, special attention has been paid to marine origin compounds such as carbohydrates, peptides, lipids, and carotenoids, which are extracted from microalgae and have anticancer, anti-inflammatory, antimicrobial (e.g., anti-COVID-19 activity), and antioxidant properties in biomedicine and pharmaceutical biotechnology. In addition, these photosynthetic marine microorganisms have several applications in biotechnology and are suitable hosts for the production of recombinant proteins/peptides, such as monoclonal antibodies and vaccines. Silica-based nanoparticles obtained from diatoms (a microalgae group) are used as drug delivery carriers owing to their biodegradability, easy functionalization, low cost, and simple features compared to synthetics, which make these agents proper alternatives for synthetic silica nanoparticles. Therefore, diatom-based nanoparticles are a viable option for the delivery of anti-cancer drugs and reducing the side-effects of cancer chemotherapy.

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Section: Microalgal-based Micro-/nanocarriers In Drug Deliverymentioning

confidence: 99%

Section: Diatom-based Nanocarriers In Cancer Therapymentioning

confidence: 99%

Microalgae: therapeutic potentials and applications

et al. 2021

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“…Silane-based chemistry is one of the most exploited modifications of the diatom surface since it offers a facile way to attach a biological or chemical molecule to the surface. Sasirekha et al [40] exploited the advantages of silanized diatom frustules using 3-aminopropyltriethoxysilane (APTES) to bind biomolecules on the diatom frustule likewise. They proposed a chitosan (Chi) grafting on Amphora frustules (Chi@AF) to encapsulate the chemotherapeutic anthracycline antibiotic Doxorubicin (DOX) in the frustule ultrastructure.…”

Section: Chemical Modification Of the Frustule Surfacementioning

confidence: 99%

“…The high porous structure allowed cells to exchange gases and turn nutrients into usable energy through the 3D-structure of the biomaterial. Contrary to many artificial bone graft materials in which porosity is formed through techniques that could be a source of potential contamination [39,40], frustules show naturally designed porous architectures. Additionally, diatom frustules can be reused subsequently to a series of washings with 96% ethanol and PBS.…”

Section: Diatom As a Promising Scaffold For Cell Proliferation And Differentiationmentioning

confidence: 99%

Nanostructured Biosilica of Diatoms: From Water World to Biomedical Applications

et al. 2020

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Diatoms—unicellular photosynthetic algae—are promising natural sources of nanostructured silica. These microorganisms produce in their membrane approximately a highly ordered porous cell wall called a frustule as protection from environmental stress. Diatom frustules consist of hydrated silica that show peculiar properties including biocompatibility, tailorable surface chemistry, chemical inertness, and thermal stability. Frustules harvested from aquatic ecosystems or diatomaceous fossil sediments represent an excellent cost-effective source of biosilica for a broad range of biomedical applications. The porous ultrastructure of the frustules displays a large surface area available for coating with various biomolecules through different functionalization methods. In this review article, we highlight the main features of diatom biosilica and present some of the most advantageous properties that support the employment of frustules in the field of drug delivery, biosensing, and regenerative medicine. In particular, it is offered an insight into the most common functionalization strategies through which diatom physicochemical properties can be modified and tailored according to the described field of application.

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“…Moreover, in vitro cytotoxicity assays on 3T3 mouse fibroblast cells revealed no toxicity of the SNAP-DE toward mammalian cells, making it a promising material in biomedical applications. Sasirekha et al used the diatom Amphora subtropica -modified with chitosan as a drug vehicle for doxorubicin, a chemotherapeutic belonging to the class of anthracyclines [72]. Doxorubicin is known to provoke many side effects, and this dose-limiting toxicity encourages research of more efficient drug delivering systems.…”

Section: Functionalized Diatoms: Smart Targeting Vehicles For Drugmentioning

confidence: 99%

Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

Delasoie

Zobi

2019

Pharmaceutics

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Unicellular diatom microalgae are a promising natural resource of porous biosilica. These microorganisms produce around their membrane a highly porous and extremely structured silica shell called frustule. Once harvested from living algae or from fossil sediments of diatomaceous earth, this biocompatible and non-toxic material offers an exceptional potential in the field of micro/nano-devices, drug delivery, theranostics, and other medical applications. The present review focused on the use of diatoms in the field of drug delivery systems, with the aim of presenting the different strategies implemented to improve the biophysical properties of this biosilica in terms of drug loading and release efficiency, targeted delivery, or site-specific binding capacity by surface functionalization. The development of composite materials involving diatoms for drug delivery applications is also described.

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Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy

Cited by 30 publications

References 46 publications

Microalgae: therapeutic potentials and applications

Microalgae: therapeutic potentials and applications

Nanostructured Biosilica of Diatoms: From Water World to Biomedical Applications

Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

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