Surface-decorated hydroxyapatite scaffold with on-demand delivery of dexamethasone and stromal cell derived factor-1 for enhanced osteogenesis

Zhang, Bingjun; Li, Hongyu; He, Lijuan; Han, Zhongchao; Zhou, Teng; Zhi, Wei; Lu, Xiaobo; Li, Xiong; Weng, Jie

doi:10.1016/j.msec.2018.04.008

Cited by 38 publications

(23 citation statements)

References 73 publications

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“…A very common type of template is spheres to obtain highly porous scaffold. For example, the use of sugar spheres has been reported to fabricate a hydroxyapatite (HAP) scaffold [14] by extruding the HAP solution to a cylindrical mold containing the sugar spheres. The resulting scaffold were then immersed in water and the sugar spheres were slowly dissolved while the HAP sol gelated.…”

Section: Ii152 Template Assisted Methodsmentioning

confidence: 99%

“…Single emulsion can also be used in combination with polymerization. As an example, Zhang et al used the reverse emulsion polymerization technique to obtain hydroxypropyl-β-cyclodextrin microspheres [14].…”

Section: Ii111 Emulsificationmentioning

confidence: 99%

“…In the domain of protein delivery device, ELISA is mainly used to detect sensitive proteins such as BMP2 [103,109], stromal cell-derived factor 1 (SDF-1) [14,104],…”

Section: Iii131 Elisamentioning

confidence: 99%

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Design and applications of protein delivery systems in nanomedicine and tissue engineering

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Mertz

2021

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Section: Ii152 Template Assisted Methodsmentioning

confidence: 99%

Section: Ii111 Emulsificationmentioning

confidence: 99%

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Design and applications of protein delivery systems in nanomedicine and tissue engineering

Bizeau

Mertz

2021

Advances in Colloid and Interface Science

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“…The local osteogenic effect of SIM is combined with the physical properties of scaffolds. [ 165,166 ] They provide a new strategy for the regeneration of bearing bone tissue.…”

Section: D Composite Materialsmentioning

confidence: 99%

Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration

Yang

Fang

et al. 2021

Macromol. Rapid Commun.

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The treatment of large segmental bone defects and complex types of fractures caused by trauma, inflammation, or tumor resection is still a challenge in the field of orthopedics. Various natural or synthetic biological materials used in clinical applications cannot fully replicate the structure and performance of raw bone. This highlights how to endow materials with multiple functions and biological properties, which is a problem that needs to be solved in practical applications. Hydrogels with outstanding biocompatibility, for their casting into any shape, size, or form, are suitable for different forms of bone defects. Therefore, they have been used in regenerative medicine more widely. In this review, versatile hydrogels are compounded with nanoparticles of different dimensions, and many desirable features of these materials in bone regeneration are introduced, including drug delivery, cell factor vehicle, cell scaffolds, which have potential in bone regeneration applications. The combination of hydrogels and nanoparticles of different dimensions encourages better filling of bone defect areas and has higher adaptability. This is due to the minimally invasive properties of the material and ability to match irregular defects. These biological characteristics make composite hydrogels with different dimensional nanoparticles become one of the most attractive options for bone regeneration materials.

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“…Compared with "gold standard" autogenous bone, the advantages of artificial bone replacement materials mainly include the unlimited amount of synthesis [ 107 ], the ability to act as drug delivery carrier [ 108 ], and the ease of functional modification [ 109 ]. Thus, giving the materials new functions such as vascularization [ 110 ], bone targeted recognition [ 111 ], and recruitment of stem cells [ 112 ], are more conducive than the physiological repair of defects. For example, Yan et al developed a 3D printed polycaprolactone (PCL) scaffold with vascularization capabilities for the repair of critical bone defects [ 113 ].…”

Section: The Destination Of Bp Tissue Engineering Application-bone Thmentioning

confidence: 99%

Black phosphorus-based 2D materials for bone therapy

Cheng

Cai

Zhao

et al. 2020

Bioactive Materials

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Since their discovery, Black Phosphorus (BP)-based nanomaterials have received extensive attentions in the fields of electromechanics, optics and biomedicine, due to their remarkable properties and excellent biocompatibility. The most essential feature of BP is that it is composed of a single phosphorus element, which has a high degree of homology with the inorganic components of natural bone, therefore it has a full advantage in the treatment of bone defects. This review will first introduce the source, physicochemical properties, and degradation products of BP, then introduce the remodeling process of bone, and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels, polymer membranes, microspheres, and three-dimensional (3D) printed scaffolds. Finally, we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

show abstract

Surface-decorated hydroxyapatite scaffold with on-demand delivery of dexamethasone and stromal cell derived factor-1 for enhanced osteogenesis

Cited by 38 publications

References 73 publications

Design and applications of protein delivery systems in nanomedicine and tissue engineering

Design and applications of protein delivery systems in nanomedicine and tissue engineering

Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration

Black phosphorus-based 2D materials for bone therapy

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