“…At present, research on adhesive materials in the drug delivery phase mainly aims at precise targeting and dosing, and low toxicity in order to achieve the best therapeutic effect. 109 Adhesive materials can provide space and time control for the release of various therapeutic drugs, including small-molecule and macromolecule drugs, and cells. 35,39 Adhesive materials have the characteristics of adjustable physical properties, controllable degradability to protect unstable drugs from degradation, 110 and the use of a platform for various physical chemistry interactions between the adhesive material and encapsulated drug, which can also reduce the administration frequency for convenient medication.…”
Adhesive materials are natural or synthetic polymers with the ability to adhere to the surface of luminal mucus or epithelial cells. They are widely used in the biomedical field due...
“…At present, research on adhesive materials in the drug delivery phase mainly aims at precise targeting and dosing, and low toxicity in order to achieve the best therapeutic effect. 109 Adhesive materials can provide space and time control for the release of various therapeutic drugs, including small-molecule and macromolecule drugs, and cells. 35,39 Adhesive materials have the characteristics of adjustable physical properties, controllable degradability to protect unstable drugs from degradation, 110 and the use of a platform for various physical chemistry interactions between the adhesive material and encapsulated drug, which can also reduce the administration frequency for convenient medication.…”
Adhesive materials are natural or synthetic polymers with the ability to adhere to the surface of luminal mucus or epithelial cells. They are widely used in the biomedical field due...
“…Incorporating drugs, such as antibiotics, is an effective means of rapid sterilization during early implantation stages. For example, Zhou et al [154] used ciprofloxacin-loaded CS hydrogel to modify the coating, effectively sterilizing the sample with the bacteriostatic zone. Xu et al [155] covalently grafted vancomycin to the MAO coating, creating Ti-@MV with significant antibacterial properties and enhanced osteogenic differentiation of BMSCs.…”
Titanium (Ti) and its alloys are widely recognized as preferred materials for bone implants due to their superior mechanical properties. However, their natural surface bio-inertness can hinder effective tissue integration. To address this challenge, micro-arc oxidation (MAO) has emerged as an innovative electrochemical surface modification technique. Its benefits range from operational simplicity and cost-effectiveness to environmental compatibility and scalability. Furthermore, the distinctive MAO process yields a porous topography that bestows versatile functionalities for biological applications, encompassing osteogenesis, antibacterial, and anti-inflammatory properties. In this review, we undertake an examination of the underlying mechanism governing the MAO process, scrutinize the multifaceted influence of various factors on coating performance, conduct an extensive analysis of the development of diverse biological functionalities conferred by MAO coatings, and discuss the practical application of MAO in implants. Finally, we provide insights into the limitations and potential pathways for further development of this technology in the field of bone implantation.
“…A Cell Counting Kit-8 (CCK8) assay was used to test the cell viability of (COL/PS) 4 @CaCO 3 using mouse fibroblast (L929) cells. 39 The subcutaneous implantation model, which has been previously reported, 40 was used to evaluate the in vivo degrading property and host response of (COL/PS) 4 @CaCO 3 .…”
Section: Study Of Hemocompatibility Cytocompatibility and Biodegradab...mentioning
Since the hemostats are likely flushed off from the wound by massive gushing blood, achieving rapid and effective hemostasis in complex bleeding wounds with powder hemostats continues to be a...
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