Surface charge-dependent osteogenic behaviors of edge-functionalized graphene quantum dots

Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells

“…GO displays two main peaks around 230 nm (π-π* electronic transitions of the graphitic sp 2 domains), with a shoulder around 300 nm (n-π* transitions), while for GQDs such electronic transitions originate absorption bands peaked at 249 nm and had a shoulder at 287 nm. In addition, a typical broad absorption band with peaks around 370 and 390 nm can be detected in the absorption spectrum of GQDs, which is ascribed to the absorption of different surface functional groups [ 36 , 37 , 38 ].…”

“…GO displays two main peaks around 230 nm (π-π* electronic transitions of the graphitic sp 2 domains), with a shoulder around 300 nm (n-π* transitions), while for GQDs such electronic transitions originate absorption bands peaked at 249 nm and had a shoulder at 287 nm. In addition, a typical broad absorption band with peaks around 370 and 390 nm can be detected in the absorption spectrum of GQDs, which is ascribed to the absorption of different surface functional groups [36][37][38]. The GQDs solutions exhibit a bright cyan-blue fluorescence under UV light irradiation (insets Figure 2b) at a concentration as low as 0.1 µ g mL −1 , while GO aqueous suspensions do not show fluorescence in these conditions (Figure S10).…”

Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: A Review

“…In the in vivo test, the composite also enhanced the zebrafish jawbone regeneration and increased the mineral density of the injured site. At the molecular level, it is now confirmed that this phenomenon is achieved through the activation of the BMP/Smad signaling pathway, which mediates the expression of osteogenic-related genes and proteins. , A recently published study further proved that CDs can enhance the ALP activity of stem cells derived from human fat (hBFPSCs) . When used as a part of the composite materials, the addition of CDs was proven to increase mechanical strength, cell adhesion, and proliferation as well. ,− Meanwhile, since CDs also have a fluorescent tracing effect, they can be used to observe the process of intracellular osteogenic differentiation .…”

“…When used as a part of the composite materials, the addition of CDs was proven to increase mechanical strength, cell adhesion, and proliferation as well. ,− Meanwhile, since CDs also have a fluorescent tracing effect, they can be used to observe the process of intracellular osteogenic differentiation . Besides, experiments using mice and MSCs as models confirmed the osteogenic effects of CDs themselves. ,,, To be specific, Geng et al observed a prominent increase of the ALP activity and the mineralized matrix of hMSCs after being treated with negatively charged GQD . Similarly, 4 weeks after the construction of the mouse calvarial defect model, the amount of new bone was significantly higher in the GQD treated mice compared with the control group .…”

Regulation of Inflammatory Response and Osteogenesis to Citrate‐Based Biomaterials through Incorporation of Alkaline Fragments

“…The protonation of tertiary amine groups in BHEp segments altered the surface electric charge and surface free energy, and in turn changed the surface wettability, as shown in Figure 1b. [25,34]…”