Sonodynamic therapy as a promising noninvasive modality is being developed for tumor therapy, but there is a lack of next‐generation sonosensitizers that can generate full ROS at high yields and simultaneously deplete elevated levels of glutathione (GSH) in tumor cells. Semiconductor p‐n junctions are engineered as high‐efficacy sonosensitizers for sonodynamic tumor eradication using pyridine N‐doped carbon dots (N‐CDs) as a p‐type semiconductor and oxygen‐deficient TiO2−x nanosheets as a n‐type semiconductor. The rate constants of 1O2 and •OH generation by ultrasound‐excited N‐CD@TiO2−x p‐n junctions are 4.3 and 4.5 times higher than those of TiO2, respectively. A Z‐scheme carrier migration mechanism in the p‐n junction achieving the rapid spatial separation of the ultrasound‐generated electron–hole pairs for enhanced full ROS production is proposed. GSH‐cleavable, Pt‐crosslinked, N‐doped CD fluorescent probes to detect the presence of intracellular GSH are also constructed. A GSH‐responsive, p‐n junction platform (Pt/N‐CD@TiO2−x) with integrated GSH detection, GSH depletion, and enhanced sonodynamic performance is then assembled. Malignant tumors are completely eradicated without relapse via intravenous administration of low‐dose Pt/N‐CD@TiO2−x under ultrasound irradiation. This work substantiates the great potential of biocompatible, GSH‐responsive p‐n junctions as next‐generation sonosensitizers via p‐n junction‐enhanced ROS generation and metal ion oxidation of intracellular GSH.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.