Surface characterization of titanium-based substrates for orthopaedic applications

Melo-Fonseca, F.; Gasik, Michael; Madeira, S.; Silva, F.S.; Miranda, G.

doi:10.1016/j.matchar.2021.111161

Cited by 14 publications

(14 citation statements)

References 73 publications

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“…It is believed that changing the laser processing parameters (e.g., applying more power) could increase the roughness parameter value to within the desired range for implant applications. Higher surface roughness enables a more efficient osseointegration process and increases the enzymatic activity of osteoblasts [ 50 , 51 ]. The highest value of this parameter was obtained for the Ti-6Al-4V sample surface, and at the same time, this was closest to the expected value.…”

Section: Discussionmentioning

confidence: 99%

Mechanical Properties and Residual Stress Measurements of Grade IV Titanium and Ti-6Al-4V and Ti-13Nb-13Zr Titanium Alloys after Laser Treatment

Jażdżewska

Kwidzińska

Seyda³

et al. 2021

Materials

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Nowadays, surface engineering focuses on research into materials for medical applications. Titanium and its alloys are prominent, especially Ti-6Al-4V and Ti-13Nb-13Zr. Samples made of pure grade IV titanium and the titanium alloys Ti-6Al-4V and Ti-13Nb-13Zr were modified via laser treatment with laser beam frequency f = 25 Hz and laser beam power P = 1000 W during a laser pulse with duration t = 1 ms. Subsequently, to analyze the properties of the obtained surface layers, the following tests were performed: scanning electron microscopy, chemical and phase composition analysis, wetting angle tests and roughness tests. The assessment of the impact of the laser modification on the internal stresses of the investigated materials was carried out by comparing the values of the stresses of the laser-modified samples to those of the reference samples. The obtained results showed increased values of tensile stresses after laser modification: the highest value was found for the Ti-6Al-4V alloy at 6.7434 GPa and the lowest for pure grade IV titanium at 3.742 GPa. After laser and heat treatment, a reduction in the stress was observed, together with a significant increase in the hardness of the tested materials, with the highest value for Ti-6Al-4V alloy at 27.723 GPa. This can provide better abrasion resistance and lower long-term toxicity, both of which are desirable when using Ti-6Al-4V and Ti-13Nb-13Zr alloys for implant materials.

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Section: Discussionmentioning

confidence: 99%

Mechanical Properties and Residual Stress Measurements of Grade IV Titanium and Ti-6Al-4V and Ti-13Nb-13Zr Titanium Alloys after Laser Treatment

Jażdżewska

Kwidzińska

Seyda³

et al. 2021

Materials

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“…19,20 In a previous study, hydrothermally treated Ti6Al4V samples presented a moderate hydrophilic layer with both anatase and rutile crystalline phases. 19 Besides improving the corrosion resistance of the Ti6Al4V substrate due to thickness increase 21 and the presence of rutile, the most resistant crystallographic form of TiO 2 , 22,23 this protective layer has been reported to elicit a similar 24 or even mitigate 25,26 the inflammatory response. In addition, the single-step hydrothermal treatment on Ti-based substrates confers antibacterial properties, 27 promotes osteoblastic lineage, 28 and enhances osteoconductivity in vivo.…”

Section: Introductionmentioning

confidence: 87%

“…19 The as-received samples presented an arithmetic average roughness value (R a ) of 10.89 ± 2.01 nm and a water contact angle of 85 ± 3.5°, after autoclaving. 19 Samples were cleaned with ultrasonic rinsing with ethanol, dried in air, and then divided into four groups: control (Ti−O), hydrothermal treatment (Ti−H), human fibronectin coating (Ti−OC), and hydrothermal treatment followed by human fibronectin coating (Ti−HC), as displayed in Scheme 1. Samples subjected to hydrothermal treatment were immersed in a poly(tetrafluoroethylene) (PTFE, Teflon) beaker with 80 mL of distilled water and placed inside a proprietary designed reactor.…”

Section: Preparation Of Ti6al4vmentioning

confidence: 96%

Engineering a Hybrid Ti6Al4V-Based System for Responsive and Consistent Osteogenesis

Melo-Fonseca,

Gasik,

Cruz

et al. 2024

ACS Omega

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As the aging population increases worldwide, the incidence of musculoskeletal diseases and the need for orthopedic implants also arise. One of the most desirable goals in orthopedic reconstructive therapies is de novo bone formation. Yet, reproducible, long-lasting, and cost-effective strategies for implants that strongly induce osteogenesis are still in need. Nanoengineered titanium substrates (and their alloys) are among the most used materials in orthopedic implants. Although having high biocompatibility, titanium alloys hold a low bioactivity profile. The osteogenic capacity and osseointegration of Ti-based implantable systems are limited, as they critically depend on the body−substrate interactions defined by blood proteins adsorbed into implant surfaces that ultimately lead to the recruitment, proliferation, and differentiation of mesenchymal stem cells (MSCs) to comply bone formation and regeneration. In this work, a hybrid Ti6Al4V system combining micro-and nanoscale modifications induced by hydrothermal treatment followed by functionalization with a bioactive compound (fibronectin derived from human plasma) is proposed, aiming for bioactivity improvement. An evaluation of the biological activity and cellular responses in vitro with respect to bone regeneration indicated that the integration of morphological and chemical modifications into Ti6Al4V surfaces induces the osteogenic differentiation of MSCs to improve bone regeneration by an enhancement of mineral matrix formation that accelerates the osseointegration process. Overall, this hybrid system has numerous competitive advantages over more complex treatments, including reproducibility, low production cost, and potential for improved long-term maintenance of the implant.

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“…Nowadays, Ti and its alloy are extensively used in orthopedic and dental implants for their feasible mechanical features, satisfactory corrosion resistance, and good biocompatibility [ 57 , 58 , 59 ]. However, implant-associated infection is one of the major causes of Ti and its alloys failure in the human body [ 60 , 61 ].…”

Section: Temperature-responsive Hydrogels (Trhs)mentioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

142

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Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

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Surface characterization of titanium-based substrates for orthopaedic applications

Cited by 14 publications

References 73 publications

Mechanical Properties and Residual Stress Measurements of Grade IV Titanium and Ti-6Al-4V and Ti-13Nb-13Zr Titanium Alloys after Laser Treatment

Mechanical Properties and Residual Stress Measurements of Grade IV Titanium and Ti-6Al-4V and Ti-13Nb-13Zr Titanium Alloys after Laser Treatment

Engineering a Hybrid Ti6Al4V-Based System for Responsive and Consistent Osteogenesis

Smart Hydrogels for Advanced Drug Delivery Systems

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