Surface anchored metal-organic frameworks as stimulus responsive antifouling coatings

Abstract

Surface-anchored, crystalline and oriented metal organic frameworks (SURMOFs) have huge potential for biological applications due to their well-defined and highly-porous structure. In this work we describe a MOF-based, fully autonomous system, which combines sensing, a specific response, and the release of an antimicrobial agent. The Cu-containing SURMOF, Cu-SURMOF 2, is stable in artificial seawater and shows stimulus-responsive anti-fouling properties against marine bacteria. When Cobetia marina adheres on the SURMOF, the framework’s response is lethal to the adhering microorganism. A thorough analysis reveals that this response is induced by agents secreted from the microbes after adhesion to the substrate, and includes a release of Cu ions resulting from a degradation of the SURMOF. The stimulus-responsive antifouling effect of Cu-SURMOF 2 demonstrates the first application of Cu-SURMOF 2 as autonomous system with great potential for further microbiological and cell culture applications.

The Effect of Cu-BPDCA-Ty on Antibacterial Activity and The Expression of mecA Gene in Clinical and Standard Strains of Methicillin-Resistant Staphylococcus aureus

“…The antibacterial mechanism of this compound is related to the release of Cu and after destroying the wall and membrane and entering the cell, an enzymatic activity is targeted in the bacterium, which ultimately leads to a reduction in gene expression (26,27 (28,29). Similar to previous studies (30)(31)(32)(33), the present study found that the antibacterial activity of nanostructures includes metal/metal oxide copper. The real-time PCR method is sensitive and commonly used to detect gene expression.…”

Co, Zn and Ag-MOFs evaluation as biocidal materials towards photosynthetic organisms

“…New MOFs based on different metals such as Co, Zn or Cu have also emerged. In most cases, these MOFs have been successfully tested towards heterotrophic organisms like Pseudomonas putida, E. coli, Saccharomyces cerevisiae or S. aureus (Aguado et al, 2014;Wang et al, 2015;Wojciechowska et al, 2012;Zhuang et al, 2012) and to marine bacteria as Cobetia marina (Sancet et al, 2013). However, studies to examine the biocidal effect of MOFs to photosynthetic organisms as cyanobacteria or algae are lacking (Wyszogrodzka et al, 2016).…”

Metal–organic frameworks in Germany: From synthesis to function

“…The results suggest that SURMOFs can act as a release matrix for pharmaceuticals and other drugs. This study opens up the possibility of applying SURMOFs in the biochemical field [391,392].…”