Surface Analysis of Silica Gel Particles after Mechanical Dry Coating with Magnesium Stearate

Abstract

Abstract

Modeling the mean interaction forces between powder particles. Application to silica gel–magnesium stearate mixtures

“…As a consequence, for each SG-MS mixture, two mass losses can be observed (Figure 7). A calibration curve based ( Figure 8) on well-known MS-SG mixtures prepared by simple stirring has been established by measuring the second mass loss (∆m/m 0 ) [27]. The amount of remaining MS after Hybridizer dry coating experiments is deduced from the calibration curve by analysing the coated samples ( Figure 9).…”

“…Atomic interaction forces between the MS attached to the cantilever [26,27] In order to explain the evolution of the mean force f versus w I , different models of perfectly ordered coatings or partially ordered structures are considered.…”

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

“…13 In general, dry coating is simpler, cheaper, quicker, and more environmentally acceptable than the solvent-based coating alternatives because no solvent is used. 14,15 There are several types of dry coating devices and systems available including those termed as mechanofusion, 16 hybridizer, 17 comil, 18,19 fluid energy mills, 20 magnetically assisted impaction coater, 20,21 and laboratory resonant acoustic mixer. 15 The principles they share in common are the employment of high-energy and high-shear processes to coat additive "guest" excipients onto the surfaces of "host" particles.…”

Effect of operating conditions on dry particle coating in a high shear mixer

“…In real experiments, a part of the materials may also be stick on the walls of the mixer, and it would be better to choose a higher value like 5% minimum: the loss of particles on the walls is limited anyways because the area of particles is much larger than the one of the walls. The loss can reach some percents of MgSt in the example of MgSt 15%-silica mixtures [14]. In the contrary, a large particle size distribution of fine particles would rather induce lower values for the critical mass fraction w by increasing the mean size ratio k H .…”