Modeling the mean interaction forces between powder particles. Application to silica gel–magnesium stearate mixtures

Thomas, Gérard; Ouabbas, Yamina; Grosseau, Philippe; Baron, Michel; Chamayou, Alain; Galet, Laurence

doi:10.1016/j.apsusc.2009.03.099

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Then, the lactose powders with 5% MgSt showed a rough surface with many pits (Figure 2f), suggesting that MgSt formed a multi-layered film. Similar observations have been reported by Zhou et al (18) with regard to lactose powders (Pharmatose450M) coated with MgSt using mechanofusion. It was suggested that 1% MgSt was sufficient for a uniform thin-film coating of Pharmatose450M and excess MgSt seemed to form overlapping and flaking layers at the 5% level of MgSt.…”

Section: Effect Of Magnesium Stearate Amount On Coating Performancesupporting

confidence: 89%

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Dry Powder Coating using Planetary Centrifugal Mixer

Miyazaki¹,

Miyawaki²,

Uchino³

et al. 2015

J Pharm Pharm Sci

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Purpose: Extemporaneous compounding is an important part of pharmacy practice, and should be standardized and sophisticated to ensure the quality of the compounded preparations. Recently, we applied a planetary centrifugal mixer (PCM) to powder blending, which has attracted interest for its small scale and lack of contamination. In this study, we aimed to reveal the feasibility of dry powder coating through ordered mixing of fine particles using PCM. Methods: Cohesive lactose powders (Pharmatose450M) were dry coated with magnesium stearate (MgSt) using from 0.1 to 5%(w/w) content. The operational variables tested were operation time (1-30 min), operation speed (400-1000 rpm), vessel size (24-100 mL), and charging rate in the vessel (20-40%). The processed powders were evaluated for their surface morphology, flowability, and wettability. Furthermore, fine ibuprofen particles were coated with various lubricants, and then the dissolution profiles were examined. The crystallinity of ibuprofen was assessed using FT-IR and PXRD. Results: Lactose powders were successfully coated with MgSt using PCM. When the level of MgSt was over 1%, the surface of the lactose powders was thoroughly covered. Angles of repose were 51° and 41° for unprocessed and processed powders with 1% MgSt, respectively. The contact angle of the water drop on the 1% MgSt sample leached to be 132°, changing to a hydrophobic surface. Investigations under various operational conditions revealed that higher improvement was observed upon higher speed and longer time, and a smaller charging rate in the vessel. Vessel size had no impact. Moreover, improved dissolution of ibuprofen coated with both hydrophilic and hydrophobic lubricants was observed owing to good dispersing behavior. Besides, no alteration of crystallinity was detected. Conclusions: PCM is an effective tool for dry powder coating with low impact stress. The presented method will contribute a great deal to making crushed tablets a functional powder. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Section: Effect Of Magnesium Stearate Amount On Coating Performancesupporting

confidence: 89%

“…Charging rate in the vessel is one of the most important variables affecting coating performance (18). The AOR and the aerated bulk density of powders processed at the various charging rates are summarized in Table 3.…”

Section: Effect Of Charging Ratementioning

confidence: 99%

Dry Powder Coating using Planetary Centrifugal Mixer

Miyazaki¹,

Miyawaki²,

Uchino³

et al. 2015

J Pharm Pharm Sci

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“…The optimization of a dry coating process requires normally the experimental efforts and empirical techniques [1][2][3]. Several theoretical approaches have been reported [4,5].…”

Section: Introductionmentioning

confidence: 99%

Dry coating in a high shear mixer: Comparison of experimental results with DEM analysis of particle motions

Serris¹,

Sato²,

Chamayou³

et al. 2013

AIP Conference Proceedings

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Abstract. Experimental dry coating of guest particles on the surface of host particles is performed by mechanical forces in a high shear mixer called "Cyclomix". The studied system (a mixture of particles of sugar, "Suglet™" as host particles and magnesium stearate as guest particles) was chosen as a model one to achieve better understandings of the phenomena during mixing. To simulate the flow of host/guest particles in the mixer, the Discrete Element Method (DEM) was applied. Experimental results such as flowability and wettability can be explained by particles flows evolutions with different rotational speed or duration treatment inside the Cyclomix.

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“…For economic and environmental reasons, dry particle coating is a very promising method for the surface modification of industrial powders as it does not involve solvents and subsequent drying 7–9. Powdered material with a relatively large particle size (host particles; 1–500 μm) are mechanically coated with fine particles (guest particles; 0.01–50 μm) to create new functionalities or to improve their initial characteristics 10.…”

Section: Introductionmentioning

confidence: 99%

Dry coating of talc particles: Effect of material and process modifications on their wettability and dispersibility

Lefebvre¹,

Galet²,

Chamayou³

2010

AIChE Journal

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Even though dispersion operations have been the object of several investigations, the importance of the different parameters and especially the physicochemical and surface properties are rarely treated. Dry particle coating can be used to create new generation materials. In such processes, host particles are mechanically coated with guest particles, without using solvents and subsequent drying, to create new functionalities or to improve initial characteristics. This study examines the surface properties of talc particles modified by dry coating with hydrophobic silica particles. Two parameters have been studied: the concentration of silica particles and the dry coating processing time. Both parameters allow modifications of the work of adhesion of talc particles with water, which is a characteristic of wettability. This change of wettability can consequently influence the dispersion rate of talc in water.

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Modeling the mean interaction forces between powder particles. Application to silica gel–magnesium stearate mixtures

Cited by 17 publications

References 22 publications

Dry Powder Coating using Planetary Centrifugal Mixer

Dry Powder Coating using Planetary Centrifugal Mixer

Dry coating in a high shear mixer: Comparison of experimental results with DEM analysis of particle motions

Dry coating of talc particles: Effect of material and process modifications on their wettability and dispersibility

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