Dry coating in a high shear mixer: Comparison of experimental results with DEM analysis of particle motions

Serris, Eric; Sato, Akira; Chamayou, Alain; Galet, Laurence; Baron, Michel; Grosseau, Philippe; Thomas, Gérard

doi:10.1063/1.4812047

Cited by 3 publications

(12 citation statements)

References 16 publications

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“…These are the conical mills designed with a unique mixing principle to suit varieties of application 39 . The machine possesses ability to combine different processes 40 . It is chosen ideally for intensive thermal processing with high energy input, high degree of homogeneity and dispersion, and ultra-short cycle times 41 .…”

Section: Cyclomix®mentioning

confidence: 99%

“… Unique mixing action: Achieves fast mixing (ultra-short cycle time) with high degrees of homogeneity & material dispersion 40,41 .…”

Section: Featuresmentioning

confidence: 99%

“… Jacket for highly efficient heat transfer: The machine designed with jacket makes an efficient use of surface for heat transfer 39 . This is for allowing more efficient cooling to be occurring while processing thermo-labile materials 40 .…”

Section: Featuresmentioning

confidence: 99%

“…The machine comprises of a conical shaped mixing vessel, a top driven central rotor assembly, a domed cover at the top of vessel, and a knife blade 40 , refer Figure -8. The rotor assembly has numerous paddles and is cantilevered with drive at the top to drive the paddles 41 .…”

Section: Principle and Operationmentioning

confidence: 99%

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Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals

Saikh¹,

Mohapatra²

2021

J. Drug Delivery Ther.

189

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The manuscript aims to provide glimpse on updated information relating thermo-mechanical dry coating processes (TMDCP) suiting in modifying surface attributes of fine and ultra-fine particle (FiUlFiP). FiUlFiPs are the integral component of pharmaceutical processes. They exhibit complex and queer properties, are conferred mostly from their surface attributes colligated with their higher surface area. Particle engineering technocrats extensively working for modifying surface & surface attributes of FiUlFiPs. These efforts are to find their worthy applications & new functionalities. Among available diverse particle engineering technologies/ process, TMDCP, a dry coating process (DCP), advocated being worthy and efficient. The TMDCP finds multidisciplinary applications, mostly in drug development & drug delivery. Said DCP involves fixing and/or attaching coating material (CoM) as particles herein synonym guest particle (GP) onto core/substrate particle (CSP) herein synonym host particle (HP). Attaching/ fixing the GPs onto HPs, in TMDCP, involve their mechanical and/or thermal interactions. Scientific literatures are evidencing diverse techniques and/or process, basing on discussed interactions. Amongst them novel techniques/ processes are Hybridization, Magnetically assisted impaction coating process (MAICP), Mechanofusion, Theta-composer, and high shear compaction. In this area diverse devices/ equipments are prevailing in market. Important are Hybridizer, Magnetically assisted impaction coater (MAIC), Theta-composer, Mechanofusion, Quadro Comil®, Cyclomix®, and many others. Attempt of this article is to discuss and present their method of working, working principle, applicability, limitations, and benefits. Contained information might be beneficial for professionals of pharmaceutical and allied field. Keywords: dry coating, equipment, particles, processes, thermo-mechanical.

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Section: Cyclomix®mentioning

confidence: 99%

“… Unique mixing action: Achieves fast mixing (ultra-short cycle time) with high degrees of homogeneity & material dispersion 40,41 .…”

Section: Featuresmentioning

confidence: 99%

Section: Featuresmentioning

confidence: 99%

Section: Principle and Operationmentioning

confidence: 99%

See 2 more Smart Citations

Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals

Saikh¹,

Mohapatra²

2021

J. Drug Delivery Ther.

189

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“…The particle coating is used to modify the properties of powders by using mechanical forces to attach the guest particles to the surface of the host particles. The coating of fine guest particles onto the surface of host particles is accomplished through shear and impact forces generated during the ball milling process [2,6,7]. The use of ball milling machines for the fabrication of metal-based nanocomposites has been extensively investigated [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Milling Media for Surface Coating on the Copper Powder Using Two Kinds of Ball Mills with Discrete Element Method Simulation

et al. 2020

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This study investigated the effect of three different ball materials on the metal-based carbon nanotube (CNT) composites used as surface coatings on metal-powder to fabricate high-quality nanocomposites. The effect of ball material, different rotation speeds, and milling times on the coating characteristics of the metal-based nanocomposite were studied. The mechanical dry coating was used to fabricate CNT coatings on the surface of copper powder particles via two different ball milling machines such as a traditional ball mill and a stirred ball mill. We explored the effect of the milling media of the ball mill under different ball materials and ball sizes on the metal powder during the ball milling process with DEM simulation. Using discrete element method simulation to obtain the average velocity, force, and, kinetic energy of the milling media in a low and high energy ball mills.

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