Surface Alterations to Impart Antiviral Properties to Combat COVID-19 Transmission

Abstract

A global epidemic caused by highly transmittable COVID-19 is causing severe loss of human life. In this study, two aspects of reducing transmission of COVID-19 virus, due to surface contact, are discussed: first refers to the effect of nanocarbon fullerene C 60 coating on surface, that causes lipid peroxidation on the phospholipid layer present in the outer envelope of COVID-19; the second aspect refers to creating hydrophobic surfaces by texturing them, so that the contact area between virus and surface is minimized due to the presence of entrapped air between the topographies. These can be similar to micro-/ nano-multiscale textured surfaces that have anti-biofouling properties. Fullerene-coated surfaces can be seen as a possible solution to decrease the adhesion of virus on the surface, as they will be hydrophobic as well as toxic to the envelope.

COVID-19: Pathophysiology, treatment options, nanotechnology approaches, and research agenda to combating the SARS-CoV2 pandemic

“…Munoz et al synthesized amphiphilic glycodendro fullerene monoadducts and tested for antiviral activity in an experimental infection assay using Ebola virus glycoprotein pseudotyped viral particles on Jurkat cells over expressing DC-SIGN and an improvement in the IC50 [ 84 ]. Siddiquie et al discussed that fullerene-coated surfaces with size less than 60 nm can be used to decrease the adhesion of virus on the surface, as they will be hydrophobic as well as toxic to the envelope and prevent transmission [ 85 ]. In this regard, fullerenes can be considered as attractive spherical frameworks for a multivalent presentation of ligands.…”

Sanitization During and After COVID-19 Pandemic: A Short Review

“…Sanitization based research is a void where technologies and research other than those focused on chemical disinfectants can play a crucial role. Fluid dynamics (Bhardwaj and Agrawal 2020 ), LEDs (Tseng and Li 2007 ; McDevitt et al 2012 ), surface treatment using carbon nanotubes (Kashyap and Saha 2020 ), nanocarbons like activated fullerene (Siddiquie et al 2020 ) and TiO 2 nanoparticles hydrophobic coating (Mahapatra et al 2020 ) along with many more strands of science need to focus and contribute to an area as common as sanitization.…”

Role of different types of nanomaterials against diagnosis, prevention and therapy of COVID-19

“…Based on Fig. 4 ( Siddiquie, Agrawal, & Joshi, 2020 ), the surface contact of the textured surface is coated by C60 that leads to lipid peroxidation on the phospholipid layer that exists in the outer layer of COVID-19. Besides, the hydrophobic properties of C60 lead to minimizing contact between texture surface and virus outer layer because of the existence of entrapped air bubbles.…”